CA2608599A1 - Bicyclic derivatives as modulators of ion channels - Google Patents
Bicyclic derivatives as modulators of ion channels Download PDFInfo
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- CA2608599A1 CA2608599A1 CA002608599A CA2608599A CA2608599A1 CA 2608599 A1 CA2608599 A1 CA 2608599A1 CA 002608599 A CA002608599 A CA 002608599A CA 2608599 A CA2608599 A CA 2608599A CA 2608599 A1 CA2608599 A1 CA 2608599A1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68151905P | 2005-05-16 | 2005-05-16 | |
| US60/681,519 | 2005-05-16 | ||
| PCT/US2006/018669 WO2006124744A1 (en) | 2005-05-16 | 2006-05-12 | Bicyclic derivatives as modulators of ion channels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2608599A1 true CA2608599A1 (en) | 2006-11-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002608599A Abandoned CA2608599A1 (en) | 2005-05-16 | 2006-05-12 | Bicyclic derivatives as modulators of ion channels |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7745629B2 (https=) |
| EP (1) | EP1888558B1 (https=) |
| JP (2) | JP2008540661A (https=) |
| KR (1) | KR20080021030A (https=) |
| CN (1) | CN101218226A (https=) |
| AT (1) | ATE527251T1 (https=) |
| AU (1) | AU2006247478A1 (https=) |
| CA (1) | CA2608599A1 (https=) |
| IL (1) | IL187382A0 (https=) |
| MX (1) | MX2007014486A (https=) |
| NO (1) | NO20076447L (https=) |
| RU (1) | RU2007146769A (https=) |
| WO (1) | WO2006124744A1 (https=) |
| ZA (1) | ZA200710332B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20080015102A (ko) * | 2005-05-10 | 2008-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| NZ593074A (en) | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| WO2008101029A2 (en) * | 2007-02-13 | 2008-08-21 | Xenon Pharmaceuticals Inc. | Use of thiazole, oxazole and imidazole compounds for the treatment of sodium channel-mediated diseases or conditions |
| AU2008256937A1 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| WO2009045381A1 (en) * | 2007-10-04 | 2009-04-09 | Merck & Co., Inc. | N-substituted oxindoline derivatives as calcium channel blockers |
| EP2231655B1 (en) | 2007-11-13 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain |
| CN101910166A (zh) * | 2007-11-13 | 2010-12-08 | 沃泰克斯药物股份有限公司 | 用作钠离子通道调节剂的杂环衍生物 |
| WO2009133641A1 (ja) * | 2008-04-30 | 2009-11-05 | シャープ株式会社 | 照明装置、及び表示装置 |
| RU2011103451A (ru) * | 2008-07-01 | 2012-08-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
| US20130109672A1 (en) | 2010-04-29 | 2013-05-02 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Activators of human pyruvate kinase |
| EP2788332A1 (en) | 2011-12-07 | 2014-10-15 | Amgen, Inc. | Bicyclic aryl and heteroaryl sodium channel inhibitors |
| US8889741B2 (en) * | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
| WO2014201173A1 (en) | 2013-06-12 | 2014-12-18 | Amgen Inc. | Bicyclic sulfonamide compounds as sodium channel inhibitors |
| EP3102569A1 (en) | 2014-02-06 | 2016-12-14 | AbbVie Inc. | 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
| AU2019302534B2 (en) | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| AU2019301628C1 (en) | 2018-07-09 | 2025-02-06 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
| KR102823056B1 (ko) | 2019-06-18 | 2025-06-23 | 화이자 인코포레이티드 | 벤즈이속사졸 설폰아마이드 유도체 |
| JP7739051B2 (ja) | 2020-06-10 | 2025-09-16 | アムジエン・インコーポレーテツド | シクロブチルジヒドロキノリンスルホンアミド化合物 |
| CN115073370B (zh) * | 2021-03-10 | 2024-12-17 | 成都硕德药业有限公司 | 新型烷基氨类化合物或盐、异构体、其制备方法及用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
| CA2301549A1 (en) * | 1997-08-28 | 1999-03-04 | Piyasena Hewawasam | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators |
| GB0217431D0 (en) * | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| US7157577B2 (en) * | 2003-03-07 | 2007-01-02 | Sugen Inc. | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors |
| US7009052B2 (en) * | 2003-03-20 | 2006-03-07 | Warner Lambert Company Llc | Sulfonamide derivatives |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| US8202861B2 (en) * | 2003-08-08 | 2012-06-19 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20080015102A (ko) * | 2005-05-10 | 2008-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| MX2007015726A (es) * | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| RU2008118350A (ru) * | 2005-10-12 | 2009-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| NZ593074A (en) * | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| CN101910166A (zh) * | 2007-11-13 | 2010-12-08 | 沃泰克斯药物股份有限公司 | 用作钠离子通道调节剂的杂环衍生物 |
| EP2231655B1 (en) * | 2007-11-13 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain |
| US8697739B2 (en) * | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
-
2006
- 2006-05-12 AT AT06770340T patent/ATE527251T1/de not_active IP Right Cessation
- 2006-05-12 AU AU2006247478A patent/AU2006247478A1/en not_active Abandoned
- 2006-05-12 CA CA002608599A patent/CA2608599A1/en not_active Abandoned
- 2006-05-12 JP JP2008512394A patent/JP2008540661A/ja not_active Ceased
- 2006-05-12 KR KR1020077029355A patent/KR20080021030A/ko not_active Withdrawn
- 2006-05-12 CN CNA2006800252561A patent/CN101218226A/zh active Pending
- 2006-05-12 EP EP06770340A patent/EP1888558B1/en not_active Not-in-force
- 2006-05-12 RU RU2007146769/04A patent/RU2007146769A/ru not_active Application Discontinuation
- 2006-05-12 MX MX2007014486A patent/MX2007014486A/es not_active Application Discontinuation
- 2006-05-12 ZA ZA200710332A patent/ZA200710332B/xx unknown
- 2006-05-12 US US11/432,997 patent/US7745629B2/en active Active
- 2006-05-12 WO PCT/US2006/018669 patent/WO2006124744A1/en not_active Ceased
-
2007
- 2007-11-15 IL IL187382A patent/IL187382A0/en unknown
- 2007-12-14 NO NO20076447A patent/NO20076447L/no not_active Application Discontinuation
-
2010
- 2010-04-16 US US12/761,502 patent/US8314125B2/en active Active
-
2012
- 2012-03-28 JP JP2012074138A patent/JP2012126744A/ja not_active Withdrawn
- 2012-11-16 US US13/679,028 patent/US8536195B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| NO20076447L (no) | 2008-02-08 |
| US20130084639A1 (en) | 2013-04-04 |
| US20100204255A1 (en) | 2010-08-12 |
| MX2007014486A (es) | 2008-02-12 |
| EP1888558B1 (en) | 2011-10-05 |
| ZA200710332B (en) | 2009-03-25 |
| JP2012126744A (ja) | 2012-07-05 |
| KR20080021030A (ko) | 2008-03-06 |
| AU2006247478A1 (en) | 2006-11-23 |
| CN101218226A (zh) | 2008-07-09 |
| US8536195B2 (en) | 2013-09-17 |
| US7745629B2 (en) | 2010-06-29 |
| US8314125B2 (en) | 2012-11-20 |
| EP1888558A1 (en) | 2008-02-20 |
| RU2007146769A (ru) | 2009-06-27 |
| IL187382A0 (en) | 2008-02-09 |
| JP2008540661A (ja) | 2008-11-20 |
| ATE527251T1 (de) | 2011-10-15 |
| WO2006124744A1 (en) | 2006-11-23 |
| US20080119453A1 (en) | 2008-05-22 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |