CA2603127A1 - Utilisation de spirostenols dans le traitement des troubles mitochondriaux - Google Patents

Utilisation de spirostenols dans le traitement des troubles mitochondriaux Download PDF

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Publication number
CA2603127A1
CA2603127A1 CA002603127A CA2603127A CA2603127A1 CA 2603127 A1 CA2603127 A1 CA 2603127A1 CA 002603127 A CA002603127 A CA 002603127A CA 2603127 A CA2603127 A CA 2603127A CA 2603127 A1 CA2603127 A1 CA 2603127A1
Authority
CA
Canada
Prior art keywords
alkyl
mitochondrial
compound
hydroxy
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002603127A
Other languages
English (en)
Inventor
Laurent Lecanu
Laurent Tillement
Vassilios Papadopoulos
Wenguo Yao
Janet Greeson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Georgetown University
Samaritan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University, Samaritan Pharmaceuticals Inc filed Critical Georgetown University
Publication of CA2603127A1 publication Critical patent/CA2603127A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CA002603127A 2005-04-01 2006-03-31 Utilisation de spirostenols dans le traitement des troubles mitochondriaux Abandoned CA2603127A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66722905P 2005-04-01 2005-04-01
US60/667,229 2005-04-01
US69751805P 2005-07-08 2005-07-08
US60/697,518 2005-07-08
PCT/US2006/012380 WO2006107902A2 (fr) 2005-04-01 2006-03-31 Utilisation de spirostenols dans le traitement des troubles mitochondriaux

Publications (1)

Publication Number Publication Date
CA2603127A1 true CA2603127A1 (fr) 2006-10-12

Family

ID=36676082

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002603127A Abandoned CA2603127A1 (fr) 2005-04-01 2006-03-31 Utilisation de spirostenols dans le traitement des troubles mitochondriaux

Country Status (5)

Country Link
EP (1) EP1893219A2 (fr)
JP (1) JP2008534623A (fr)
AU (1) AU2006231451A1 (fr)
CA (1) CA2603127A1 (fr)
WO (1) WO2006107902A2 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680289A (en) * 1985-06-05 1987-07-14 Progenics, Inc. Treatment of obesity and diabetes using sapogenins
WO2003022287A1 (fr) * 2001-08-24 2003-03-20 Jilin Tianyao Science And Technology Co. Ltd. UTILISATION DE 3β-HYDROXY-5-SPIROSTENE POUR PREVENIR OU TRAITER DES MALADIES OU DES ETATS CARDIO-VASCULAIRES, INHIBER DES TUMEURS ET REDUIRE LES LIPIDES SANGUINS
AU2003218180B2 (en) * 2002-03-15 2008-03-20 Georgetown University Neuroprotective spirostenol pharmaceutical compositions
WO2003086411A1 (fr) * 2002-04-15 2003-10-23 Chengdu Di'ao Pharmaceutical Group Co., Ltd. Composes et techniques de preparation de carboxylate de diosgenine et d'un derive de succinate monoester de diosgenine
CN1187055C (zh) * 2002-06-21 2005-02-02 成都地奥制药集团有限公司 薯蓣皂甙元在制备治疗心肌缺血、心绞痛和心肌梗死的药物中的用途
CN1224628C (zh) * 2003-11-29 2005-10-26 刘良 澳洲茄胺硫酸盐及其制备方法和在医药上的应用
CA2584333A1 (fr) * 2004-10-14 2006-04-27 Georgetown University Compositions pharmaceutiques neuroprotectrices contenant du spirostenol

Also Published As

Publication number Publication date
WO2006107902A2 (fr) 2006-10-12
WO2006107902A8 (fr) 2008-01-24
WO2006107902A9 (fr) 2007-01-18
WO2006107902A3 (fr) 2006-11-30
JP2008534623A (ja) 2008-08-28
AU2006231451A1 (en) 2006-10-12
EP1893219A2 (fr) 2008-03-05

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