CA2598600C - Cell for conducting electrochemiluminescence measurements - Google Patents
Cell for conducting electrochemiluminescence measurements Download PDFInfo
- Publication number
- CA2598600C CA2598600C CA2598600A CA2598600A CA2598600C CA 2598600 C CA2598600 C CA 2598600C CA 2598600 A CA2598600 A CA 2598600A CA 2598600 A CA2598600 A CA 2598600A CA 2598600 C CA2598600 C CA 2598600C
- Authority
- CA
- Canada
- Prior art keywords
- measurement cell
- cell cavity
- cavity
- fluid
- measurement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000005259 measurement Methods 0.000 title claims abstract description 139
- 239000012530 fluid Substances 0.000 claims abstract description 60
- 230000007704 transition Effects 0.000 claims abstract description 9
- 230000003287 optical effect Effects 0.000 claims abstract description 8
- 230000000694 effects Effects 0.000 claims abstract description 7
- 230000001939 inductive effect Effects 0.000 claims abstract description 7
- 238000007599 discharging Methods 0.000 claims abstract description 4
- 230000002093 peripheral effect Effects 0.000 claims description 14
- 125000006850 spacer group Chemical group 0.000 claims description 13
- 239000011796 hollow space material Substances 0.000 claims description 4
- 239000006249 magnetic particle Substances 0.000 description 13
- 239000000203 mixture Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 238000009739 binding Methods 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000000504 luminescence detection Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Optical Measuring Cells (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06017810.0 | 2006-08-25 | ||
| EP06017810A EP1892524B1 (en) | 2006-08-25 | 2006-08-25 | Cell for conducting electrochemiluminescence measurements |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2598600A1 CA2598600A1 (en) | 2008-02-25 |
| CA2598600C true CA2598600C (en) | 2013-08-13 |
Family
ID=37633622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2598600A Active CA2598600C (en) | 2006-08-25 | 2007-08-24 | Cell for conducting electrochemiluminescence measurements |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8940230B2 (enExample) |
| EP (1) | EP1892524B1 (enExample) |
| JP (1) | JP5265895B2 (enExample) |
| CN (1) | CN101131361B (enExample) |
| AT (1) | ATE530895T1 (enExample) |
| CA (1) | CA2598600C (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102933967B (zh) * | 2010-06-09 | 2015-03-18 | 株式会社日立高新技术 | 试样分析装置和试样分析方法 |
| HUE029030T2 (en) | 2010-10-25 | 2017-01-30 | Hoffmann La Roche | Use of signal repair compounds for electrochemiluminescence detection |
| EP2799871B1 (en) * | 2011-12-28 | 2021-10-13 | Hitachi High-Tech Corporation | Sample analysis device and sample analysis method |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| JP6239243B2 (ja) * | 2013-02-08 | 2017-11-29 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 自動分析装置 |
| KR102425339B1 (ko) | 2014-12-08 | 2022-07-25 | 에프. 호프만-라 로슈 아게 | 비타민 d 의 측정을 위한 방법 |
| CN105806828B (zh) * | 2015-10-29 | 2019-05-14 | 北京联众泰克科技有限公司 | 一种电化学发光免疫分析系统及其流通池组件 |
| WO2017153574A1 (en) | 2016-03-11 | 2017-09-14 | Roche Diagnostics Gmbh | Branched-chain amines in electrochemiluminescence detection |
| JP6731815B2 (ja) * | 2016-09-08 | 2020-07-29 | 株式会社日立ハイテク | 自動分析装置 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA893143B (en) * | 1988-04-28 | 1990-01-31 | Igen Inc | Apparatus for conducting a plurality or simultaneous measurements of electrochemiluminescent phenomena |
| IL90105A (en) | 1988-04-29 | 1993-05-13 | Igen Inc | Method and apparatus for conducting electro- chemiluminescence measurements |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| US5746974A (en) | 1988-11-03 | 1998-05-05 | Igen International, Inc. | Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection |
| DE4342942A1 (de) * | 1993-12-16 | 1995-06-22 | Boehringer Mannheim Gmbh | Vorrichtung und Verfahren zur Erzeugung optisch detektierbarer Signale durch Anlegen elektrischer Potentiale an Probeflüssigkeiten |
| US5538687A (en) * | 1994-12-16 | 1996-07-23 | Behringer Mannheim Gmbh | Apparatus for generating optically detectable signals by applying electrical potentials to sample liquids |
| JPH09189662A (ja) * | 1996-01-08 | 1997-07-22 | Hitachi Ltd | 電気化学発光セル及び電気化学発光分析装置 |
| JP3641100B2 (ja) * | 1997-05-27 | 2005-04-20 | ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 電気化学発光検出セル |
| DE19803528A1 (de) | 1998-01-30 | 1999-08-05 | Roche Diagnostics Gmbh | Verfahren zur Analyse einer Probe mittels eines Elektrochemolumineszenz-Bindungsreaktion-Tests |
| JP2005241522A (ja) * | 2004-02-27 | 2005-09-08 | Horiba Advanced Techno Co Ltd | 流体分析装置 |
| US20030175947A1 (en) * | 2001-11-05 | 2003-09-18 | Liu Robin Hui | Enhanced mixing in microfluidic devices |
| CN1323296C (zh) * | 2004-07-05 | 2007-06-27 | 江苏省肿瘤医院 | 硅烷交联壳聚糖膜基的流动注射化学发光免疫检测池及制备方法 |
-
2006
- 2006-08-25 AT AT06017810T patent/ATE530895T1/de active
- 2006-08-25 EP EP06017810A patent/EP1892524B1/en active Active
-
2007
- 2007-08-17 JP JP2007213073A patent/JP5265895B2/ja active Active
- 2007-08-23 US US11/895,271 patent/US8940230B2/en active Active
- 2007-08-24 CA CA2598600A patent/CA2598600C/en active Active
- 2007-08-24 CN CN200710146851.7A patent/CN101131361B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1118097A1 (en) | 2009-01-30 |
| US20080047332A1 (en) | 2008-02-28 |
| ATE530895T1 (de) | 2011-11-15 |
| US8940230B2 (en) | 2015-01-27 |
| JP2008051813A (ja) | 2008-03-06 |
| CA2598600A1 (en) | 2008-02-25 |
| JP5265895B2 (ja) | 2013-08-14 |
| CN101131361B (zh) | 2010-09-29 |
| EP1892524A1 (en) | 2008-02-27 |
| EP1892524B1 (en) | 2011-10-26 |
| CN101131361A (zh) | 2008-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |