CA2598234A1 - Inhibition de la proteine-1 apparentee a frizzled induite par l'arni pour le traitement du glaucome - Google Patents

Inhibition de la proteine-1 apparentee a frizzled induite par l'arni pour le traitement du glaucome Download PDF

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Publication number
CA2598234A1
CA2598234A1 CA002598234A CA2598234A CA2598234A1 CA 2598234 A1 CA2598234 A1 CA 2598234A1 CA 002598234 A CA002598234 A CA 002598234A CA 2598234 A CA2598234 A CA 2598234A CA 2598234 A1 CA2598234 A1 CA 2598234A1
Authority
CA
Canada
Prior art keywords
seq
interfering rna
nucleotides
mrna corresponding
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002598234A
Other languages
English (en)
Inventor
Abbot F. Clark
Wan-Heng Wang
Loretta Graves Mcnatt
Jon E. Chatterton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon, Inc.
Abbot F. Clark
Wan-Heng Wang
Loretta Graves Mcnatt
Jon E. Chatterton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon, Inc., Abbot F. Clark, Wan-Heng Wang, Loretta Graves Mcnatt, Jon E. Chatterton filed Critical Alcon, Inc.
Publication of CA2598234A1 publication Critical patent/CA2598234A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/316—Phosphonothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002598234A 2005-03-11 2006-03-10 Inhibition de la proteine-1 apparentee a frizzled induite par l'arni pour le traitement du glaucome Abandoned CA2598234A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66055605P 2005-03-11 2005-03-11
US60/660,556 2005-03-11
US68863305P 2005-06-08 2005-06-08
US60/688,633 2005-06-08
PCT/US2006/009000 WO2006099353A1 (fr) 2005-03-11 2006-03-10 Inhibition de la proteine-1 apparentee a frizzled induite par l'arni pour le traitement du glaucome

Publications (1)

Publication Number Publication Date
CA2598234A1 true CA2598234A1 (fr) 2006-09-21

Family

ID=36649793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002598234A Abandoned CA2598234A1 (fr) 2005-03-11 2006-03-10 Inhibition de la proteine-1 apparentee a frizzled induite par l'arni pour le traitement du glaucome

Country Status (9)

Country Link
US (5) US7947660B2 (fr)
EP (1) EP1856259A1 (fr)
JP (2) JP2008533050A (fr)
KR (1) KR20080018858A (fr)
AU (1) AU2006223131A1 (fr)
BR (1) BRPI0609206A2 (fr)
CA (1) CA2598234A1 (fr)
MX (1) MX2007010608A (fr)
WO (1) WO2006099353A1 (fr)

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GB0521351D0 (en) 2005-10-20 2005-11-30 Genomica Sau Modulation of TRPV expression levels
GB0521716D0 (en) 2005-10-25 2005-11-30 Genomica Sau Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
EP2192926A1 (fr) * 2007-10-01 2010-06-09 Alcon Research, Ltd. Administration autocomplémentaire provoquée par aav de molécules d'arn interférentes pour traiter ou prévenir des troubles oculaires
US7973019B1 (en) 2007-10-03 2011-07-05 Alcon Research, Ltd. Transferrin/transferrin receptor-mediated siRNA delivery
WO2009065022A2 (fr) 2007-11-15 2009-05-22 Alcon Research, Ltd. Administration d'arnic médiée par un récepteur de lipoprotéine basse densité
AR069704A1 (es) 2007-12-18 2010-02-10 Alcon Res Ltd Sistema de administracion de rnai de interferencia y usos del mismo
EP3520749A1 (fr) 2010-10-15 2019-08-07 Clearside Biomedical, Inc. Dispositif d'accès oculaire
WO2012161677A1 (fr) 2011-05-20 2012-11-29 Alcon Research, Ltd. Administration de petit arn interférent médié par la transferrine/le récepteur de la transferrine
US20130178421A1 (en) 2012-01-06 2013-07-11 Alcon Research, Ltd. Interfering rna delivery system and uses thereof
ES2750125T3 (es) 2012-09-05 2020-03-25 Sylentis Sau ARNip y su uso en métodos y composiciones para el tratamiento y/o la prevención de afecciones oculares
GB201215857D0 (en) 2012-09-05 2012-10-24 Sylentis Sau siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
MX2015005839A (es) 2012-11-08 2015-12-17 Clearside Biomedical Inc Metodos y dispositivos para el tratamiento de trastornos oculares en sujetos humanos.
AU2014259694B2 (en) 2013-05-03 2018-11-08 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
WO2014197317A1 (fr) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Appareil et procédés pour une administration de médicament à l'aide de multiples réservoirs
WO2015132303A1 (fr) 2014-03-04 2015-09-11 Sylentis Sau Arnsi et leur utilisation dans des méthodes et des compositions pour le traitement et/ou la prévention d'affections oculaires
WO2015196085A2 (fr) 2014-06-20 2015-12-23 Clearside Biomedical, Inc. Canule à diamètre variable et procédés de commande de profondeur d'insertion pour administration de médicaments
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
WO2017139375A1 (fr) 2016-02-10 2017-08-17 Clearside Biomedical, Inc. Kit d'injection oculaire, conditionnement et procédés d'utilisation
JP2019514581A (ja) 2016-05-02 2019-06-06 クリアサイド バイオメディカル，インコーポレイテッド 眼の薬物送達のためのシステムおよび方法
EP3496680A1 (fr) 2016-08-12 2019-06-19 Clearside Biomedical, Inc. Dispositifs et procédés de réglage de la profondeur d'insertion d'une aiguille pour administration de médicament
EP3917625A4 (fr) * 2019-01-29 2023-06-21 The Regents of The University of California Nouveaux traitement du glaucome
US20230201371A1 (en) * 2020-03-19 2023-06-29 Clearside Biomedical, Inc. Compositions and methods for treating ocular disorders
WO2023239756A1 (fr) 2022-06-07 2023-12-14 Generation Bio Co. Compositions de nanoparticules lipidiques et leurs utilisations

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Also Published As

Publication number Publication date
US20170073681A1 (en) 2017-03-16
WO2006099353A1 (fr) 2006-09-21
AU2006223131A1 (en) 2006-09-21
US9040494B2 (en) 2015-05-26
BRPI0609206A2 (pt) 2010-03-02
JP2008533050A (ja) 2008-08-21
JP2012193197A (ja) 2012-10-11
EP1856259A1 (fr) 2007-11-21
US20060223773A1 (en) 2006-10-05
US20110190381A1 (en) 2011-08-04
KR20080018858A (ko) 2008-02-28
US20120178795A1 (en) 2012-07-12
US7947660B2 (en) 2011-05-24
MX2007010608A (es) 2007-10-19
US20150307882A1 (en) 2015-10-29
US9550994B2 (en) 2017-01-24
US8173617B2 (en) 2012-05-08

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Effective date: 20141020