CA2592840C - Adipose-derived stem cells for tissue regeneration and wound healing - Google Patents

Adipose-derived stem cells for tissue regeneration and wound healing Download PDF

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Publication number
CA2592840C
CA2592840C CA2592840A CA2592840A CA2592840C CA 2592840 C CA2592840 C CA 2592840C CA 2592840 A CA2592840 A CA 2592840A CA 2592840 A CA2592840 A CA 2592840A CA 2592840 C CA2592840 C CA 2592840C
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CA
Canada
Prior art keywords
cells
adsc
adipose
tissue
tissue regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2592840A
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English (en)
French (fr)
Other versions
CA2592840A1 (en
Inventor
Chauncey B. Sayre
Francisco J. Silva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PrimeGen Biotech LLC
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PrimeGen Biotech LLC
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Filing date
Publication date
Application filed by PrimeGen Biotech LLC filed Critical PrimeGen Biotech LLC
Publication of CA2592840A1 publication Critical patent/CA2592840A1/en
Application granted granted Critical
Publication of CA2592840C publication Critical patent/CA2592840C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0667Adipose-derived stem cells [ADSC]; Adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2592840A 2004-12-30 2005-12-30 Adipose-derived stem cells for tissue regeneration and wound healing Expired - Fee Related CA2592840C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64103404P 2004-12-30 2004-12-30
US60/641,034 2004-12-30
PCT/US2005/047437 WO2006074075A2 (en) 2004-12-30 2005-12-30 Adipose-derived stem cells for tissue regeneration and wound healing

Publications (2)

Publication Number Publication Date
CA2592840A1 CA2592840A1 (en) 2006-07-13
CA2592840C true CA2592840C (en) 2015-11-24

Family

ID=36588983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2592840A Expired - Fee Related CA2592840C (en) 2004-12-30 2005-12-30 Adipose-derived stem cells for tissue regeneration and wound healing

Country Status (6)

Country Link
US (1) US8119398B2 (https=)
EP (1) EP1830862B1 (https=)
JP (1) JP2008526762A (https=)
AU (1) AU2005322873B2 (https=)
CA (1) CA2592840C (https=)
WO (1) WO2006074075A2 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9144583B2 (en) 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
WO2005035738A1 (en) * 2003-10-07 2005-04-21 Biomaster Inc. Cell differentiation of adipose-derived precursor cells
US20140193852A9 (en) * 2004-12-23 2014-07-10 Erik Vossman Adipose tissue collection and pre-processing devices for use in liposuction procedure
US8221740B2 (en) * 2005-09-26 2012-07-17 The Trustees Of Columbia University In The City Of New York Side population cells in cardiac repair
US8592209B2 (en) * 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US8899228B2 (en) 2006-02-08 2014-12-02 Cvac Systems, Inc. Combination pressure therapy for treatment of chronic pain
KR100788632B1 (ko) * 2006-06-15 2007-12-26 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포, 섬유아세포 및지방 또는 지방세포를 함유한 피부미용 또는 성형용조성물의 제조방법
WO2008018450A1 (en) * 2006-08-08 2008-02-14 National University Corporation Nagoya University Cell preparation containing multipotential stem cells originating in fat tissue
JP2010505849A (ja) * 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
EP2124722A4 (en) 2007-02-26 2012-01-04 Cvac Systems Inc COMBINATION PRESSURE THERAPY FOR SERUM FAT, STEROID MIRROR AND STEROIDOGENESIS
US11174458B2 (en) 2007-04-23 2021-11-16 Koligo Therapeutics, Inc. Cell separation apparatus and methods of use
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
JP5340564B2 (ja) * 2007-07-05 2013-11-13 ライオン株式会社 人工皮膚およびその製造方法
MX2010003019A (es) 2007-09-19 2010-04-30 Pluristem Ltd Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia.
JP2011523357A (ja) * 2008-05-06 2011-08-11 ジョスリン ダイアビーティス センター インコーポレイテッド 褐色脂肪細胞分化を誘導するための方法および組成物
WO2009152084A2 (en) 2008-06-11 2009-12-17 Cell4Vet Llc Adipose tissue-derived stem cells for veterinary use
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
US20110208162A1 (en) * 2008-10-24 2011-08-25 Indiana University Rsearch and Technology Corporation Methods for preventing aggregation of adipose stromal cells
MX2011011114A (es) * 2009-04-20 2012-04-02 Univ Indiana Res & Tech Corp Materiales y metodos para utilizar celulas madre de tejido adiposo para tratar una lesion y enfermedad pulmonar.
WO2010129775A1 (en) 2009-05-06 2010-11-11 University Of Virginia Patent Foundation Self-illuminated handheld lens for retinal examination and photography and related method thereof
KR100995133B1 (ko) * 2010-02-10 2010-11-18 허쉬바이오주식회사 지방조직 유래 줄기세포 및 단핵구로부터 세포성장인자의 생산방법 및 그 이용
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
TWI419970B (zh) * 2010-11-11 2013-12-21 Univ Nat Taiwan 使成體幹細胞產生為一球體細胞群體的方法
EP2686419B1 (en) 2011-03-18 2016-11-16 MicroVascular Tissues, Inc. Allogeneic microvascular tissue for soft tissue treatments
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
US9512405B2 (en) 2011-12-14 2016-12-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Non-enzymatic method for isolating human adipose-derived stromal stem cells
US20140074068A1 (en) * 2012-09-12 2014-03-13 Richard Ty Olmstead Multi-component method for regenerative repair of wounds implementing photonic wound debridement and stem cell deposition
US11819522B2 (en) 2012-09-19 2023-11-21 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
US9713629B2 (en) 2012-09-19 2017-07-25 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
US10596202B2 (en) 2012-09-19 2020-03-24 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
US9872937B2 (en) 2012-09-19 2018-01-23 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
US9650608B2 (en) 2013-02-22 2017-05-16 Medivet America, Llc Activating adipose-derived stem cells for transplantation
US9782469B2 (en) 2013-04-19 2017-10-10 Changwon National University Industry Academy Cooperation Corps Anti-inflammatory, skin-regenerative, whitening, antioxidant, or wound-healing composition containing culture medium of ADSC-T cells in which T-antigen is introduced into adipose-derived stem cell as active ingredient
KR101527880B1 (ko) * 2013-04-19 2015-06-10 창원대학교 산학협력단 지방유래줄기세포에 t 항원을 도입한 adsc-t 세포의 배양액을 유효성분으로 포함하는, 피부재생용, 미백용, 항산화용 또는 상처 치료용 조성물
JP2016519939A (ja) 2013-05-22 2016-07-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 多能性ヒト脂肪成体幹細胞:単離、キャラクタリゼーションおよび臨床的意味
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
WO2016054592A1 (en) * 2014-10-03 2016-04-07 Cytori Therapeutics, Inc. Use of regenerative cells in mitigating burn progression and improving skin graft incorporation and healing
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
WO2017100425A1 (en) 2015-12-10 2017-06-15 Aesthetics Biomedical, Inc. Topical formulation for skin care
US20170258841A1 (en) * 2016-03-11 2017-09-14 Gwo Xi Stem Cell Applied Technology Co., Ltd. Pharmaceutical compositions for treating arrhythmia and therapeutics of
KR102017386B1 (ko) * 2017-11-01 2019-09-02 연세대학교 산학협력단 이식된 지방세포의 생착 증진용 조성물 및 지방 이식용 세포 치료제 조성물
EP3787702B1 (en) 2018-05-03 2024-08-07 CollPlant Ltd. Dermal fillers and applications thereof
WO2021226455A1 (en) * 2020-05-07 2021-11-11 Primegen Biotech, Llc Methods and compositions for reducing joint inflammation using mesenchymal stem cells
EP3909593A1 (en) 2020-05-15 2021-11-17 Rigshospitalet Stem cells for treating skin lesions
US20260007720A1 (en) * 2022-07-08 2026-01-08 Trustees Of Tufts College Tissue regenerative multi-drug cocktail and apparatus for delivery thereof
CN119491021B (zh) * 2024-11-13 2025-06-20 中南大学 过表达LncRNA SNHG16慢病毒载体在修复工程材料中的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4988621A (en) * 1985-05-24 1991-01-29 La Jolla Cancer Research Foundation Peptides in cell detachment and aggregation
US4879237A (en) * 1985-05-24 1989-11-07 La Jolla Cancer Research Foundation Use of peptides in control of cell attachment and detachment
US4789734A (en) * 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
WO1991010470A1 (en) 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
JPH05112456A (ja) * 1991-10-22 1993-05-07 Osaka Gas Co Ltd ゲル状軟膏
US5965997A (en) * 1997-08-20 1999-10-12 Benchmarq Microelectronics Battery monitoring circuit with storage of charge and discharge accumulation values accessible therefrom
KR100979664B1 (ko) 1999-03-10 2010-09-02 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 지방 유래 간세포 및 격자
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6777231B1 (en) * 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
AU763021B2 (en) 1999-09-14 2003-07-10 Children's Medical Center Corporation Isolation of muscle-derived stem cells and uses therefor
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
KR100930139B1 (ko) * 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
MXPA05009044A (es) 2003-02-20 2006-03-17 Macropore Biosurgery Inc Metodos para utilizar celulas derivadas de tejido adiposo en el tratamiento de condiciones cardiovasculares.

Also Published As

Publication number Publication date
JP2008526762A (ja) 2008-07-24
WO2006074075A3 (en) 2006-10-12
AU2005322873B2 (en) 2011-09-01
AU2005322873A1 (en) 2006-07-13
EP1830862A2 (en) 2007-09-12
CA2592840A1 (en) 2006-07-13
WO2006074075A2 (en) 2006-07-13
US20060147430A1 (en) 2006-07-06
EP1830862B1 (en) 2012-12-19
US8119398B2 (en) 2012-02-21

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