CA2590441A1 - Immunoglobulines comprenant principalement un glycoforme galglcnacman5glcnac2 - Google Patents
Immunoglobulines comprenant principalement un glycoforme galglcnacman5glcnac2 Download PDFInfo
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- CA2590441A1 CA2590441A1 CA002590441A CA2590441A CA2590441A1 CA 2590441 A1 CA2590441 A1 CA 2590441A1 CA 002590441 A CA002590441 A CA 002590441A CA 2590441 A CA2590441 A CA 2590441A CA 2590441 A1 CA2590441 A1 CA 2590441A1
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- immunoglobulins
- glycan
- glycans
- antibody
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- 229920000642 polymer Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000164 protein isolation Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000019254 respiratory burst Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 125000005629 sialic acid group Chemical group 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
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- 229940126622 therapeutic monoclonal antibody Drugs 0.000 description 1
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- 230000035897 transcription Effects 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
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- 238000010798 ubiquitination Methods 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
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- 238000009736 wetting Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63965704P | 2004-12-23 | 2004-12-23 | |
| US63969804P | 2004-12-23 | 2004-12-23 | |
| US60/639,657 | 2004-12-23 | ||
| US60/639,698 | 2004-12-23 | ||
| PCT/US2005/025663 WO2006071280A1 (fr) | 2004-12-23 | 2005-07-19 | Immunoglobulines comprenant principalement un glycoforme galglcnacman5glcnac2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2590441A1 true CA2590441A1 (fr) | 2006-07-06 |
Family
ID=36084254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002590441A Abandoned CA2590441A1 (fr) | 2004-12-23 | 2005-07-19 | Immunoglobulines comprenant principalement un glycoforme galglcnacman5glcnac2 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1831256A1 (fr) |
| JP (1) | JP2008525440A (fr) |
| AU (1) | AU2005322617A1 (fr) |
| CA (1) | CA2590441A1 (fr) |
| WO (1) | WO2006071280A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
| US7332299B2 (en) | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
| NZ598048A (en) | 2006-01-17 | 2013-05-31 | Synthon Biopharmaceuticals Bv | Compositions and methods for humanization and optimization of n-glycans in plants |
| ES2558689T3 (es) | 2007-05-14 | 2016-02-08 | Medimmune, Llc | Métodos para reducir los niveles de eosinófilos |
| EP2401378B1 (fr) * | 2009-02-25 | 2013-08-14 | Merck Sharp & Dohme Corp. | Ingénierie métabolique d'une voie d'assimilation du galactose dans la levure glycosynthétisée pichia pastoris |
| WO2014004549A2 (fr) | 2012-06-27 | 2014-01-03 | Amgen Inc. | Protéines de liaison anti-mésothéline |
| EP4435105A2 (fr) | 2015-09-29 | 2024-09-25 | Amgen Inc. | Inhibiteurs de l'asgr pour réduire les taux de cholestérol |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2558160T3 (es) * | 1998-12-09 | 2016-02-02 | Phyton Holdings, Llc | Glicoproteínas que tienen glicosilación de tipo humano |
| MXPA03006426A (es) * | 2001-01-19 | 2003-09-22 | Dow Chemical Co | Metodo para produccion secretoria de glicoproteina que tiene cadena de azucar humana, utilizando celula de planta. |
| US7507573B2 (en) * | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
-
2005
- 2005-07-19 CA CA002590441A patent/CA2590441A1/fr not_active Abandoned
- 2005-07-19 WO PCT/US2005/025663 patent/WO2006071280A1/fr active Application Filing
- 2005-07-19 EP EP05790215A patent/EP1831256A1/fr not_active Withdrawn
- 2005-07-19 AU AU2005322617A patent/AU2005322617A1/en not_active Abandoned
- 2005-07-19 JP JP2007548187A patent/JP2008525440A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006071280A1 (fr) | 2006-07-06 |
| JP2008525440A (ja) | 2008-07-17 |
| WO2006071280B1 (fr) | 2006-08-17 |
| AU2005322617A1 (en) | 2006-07-06 |
| EP1831256A1 (fr) | 2007-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |