CA2588595A1 - N-biaryl and n-arylheteroaryl piperazine derivatives as modulators of the 5ht2c receptor useful for the treatment of disorders related thereto - Google Patents

Info

Publication number

CA2588595A1

CA2588595A1 CA002588595A CA2588595A CA2588595A1 CA 2588595 A1 CA2588595 A1 CA 2588595A1 CA 002588595 A CA002588595 A CA 002588595A CA 2588595 A CA2588595 A CA 2588595A CA 2588595 A1 CA2588595 A1 CA 2588595A1

Authority

CA

Canada

Prior art keywords

piperazine

compound according

fluoro

biphenyl

disorders

Prior art date

2004-12-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 title claims abstract description 58
• 238000011282 treatment Methods 0.000 title claims abstract description 58
• 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract description 6
• 150000004885 piperazines Chemical class 0.000 title abstract description 5
• 150000001875 compounds Chemical class 0.000 claims abstract description 260
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• 150000002367 halogens Chemical class 0.000 claims description 33
• 241001465754 Metazoa Species 0.000 claims description 24
• 229940079593 drug Drugs 0.000 claims description 23
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
• 230000006378 damage Effects 0.000 claims description 17
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• 125000001424 substituent group Chemical group 0.000 claims description 14
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• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 10
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• NIBIUNYYIJEDNA-UHFFFAOYSA-N 1-(2-chloro-3-phenylphenyl)piperazine Chemical compound ClC1=C(N2CCNCC2)C=CC=C1C1=CC=CC=C1 NIBIUNYYIJEDNA-UHFFFAOYSA-N 0.000 claims description 4
• XHUKTFFNIQQBCJ-UHFFFAOYSA-N 1-(2-fluoro-3-phenylphenyl)piperazine Chemical compound FC1=C(N2CCNCC2)C=CC=C1C1=CC=CC=C1 XHUKTFFNIQQBCJ-UHFFFAOYSA-N 0.000 claims description 4
• XJKABXZTLBIDMP-UHFFFAOYSA-N 1-(2-fluoro-5-phenylphenyl)piperazine Chemical compound FC1=CC=C(C=2C=CC=CC=2)C=C1N1CCNCC1 XJKABXZTLBIDMP-UHFFFAOYSA-N 0.000 claims description 4
• VIBNKGRWMCNKCV-UHFFFAOYSA-N 1-(2-fluoro-5-pyridin-3-ylphenyl)piperazine Chemical compound FC1=CC=C(C=2C=NC=CC=2)C=C1N1CCNCC1 VIBNKGRWMCNKCV-UHFFFAOYSA-N 0.000 claims description 4
• KXWSDVZLJFXPRF-UHFFFAOYSA-N 1-(3-fluoro-5-phenylphenyl)piperazine Chemical compound C=1C(F)=CC(N2CCNCC2)=CC=1C1=CC=CC=C1 KXWSDVZLJFXPRF-UHFFFAOYSA-N 0.000 claims description 4
• BYCWTUDVLWJKCR-UHFFFAOYSA-N 1-(4-fluoro-3-phenylphenyl)piperazine Chemical compound FC1=CC=C(N2CCNCC2)C=C1C1=CC=CC=C1 BYCWTUDVLWJKCR-UHFFFAOYSA-N 0.000 claims description 4
• PREZEXPFQHILJA-UHFFFAOYSA-N 1-(4-fluoro-3-pyridin-3-ylphenyl)piperazine Chemical compound FC1=CC=C(N2CCNCC2)C=C1C1=CC=CN=C1 PREZEXPFQHILJA-UHFFFAOYSA-N 0.000 claims description 4
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