CA2587848A1 - Lipopeptides anti-infectieux - Google Patents
Lipopeptides anti-infectieux Download PDFInfo
- Publication number
- CA2587848A1 CA2587848A1 CA002587848A CA2587848A CA2587848A1 CA 2587848 A1 CA2587848 A1 CA 2587848A1 CA 002587848 A CA002587848 A CA 002587848A CA 2587848 A CA2587848 A CA 2587848A CA 2587848 A1 CA2587848 A1 CA 2587848A1
- Authority
- CA
- Canada
- Prior art keywords
- amino
- compound
- formula
- carbamoyl
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010028921 Lipopeptides Proteins 0.000 title description 13
- 230000002924 anti-infective effect Effects 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 538
- 238000000034 method Methods 0.000 claims abstract description 93
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 13
- -1 amino, monosubstituted amino Chemical group 0.000 claims description 402
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 338
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- 125000006239 protecting group Chemical group 0.000 claims description 142
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 129
- 239000000203 mixture Substances 0.000 claims description 95
- 150000003839 salts Chemical class 0.000 claims description 94
- 125000004442 acylamino group Chemical group 0.000 claims description 90
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- 239000001257 hydrogen Substances 0.000 claims description 22
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 125000000297 undecanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 description 1
- 229950001272 viomycin Drugs 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 1
- 229960004740 voriconazole Drugs 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229940061740 zyvox Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62705604P | 2004-11-12 | 2004-11-12 | |
| US60/627,056 | 2004-11-12 | ||
| US71070505P | 2005-08-23 | 2005-08-23 | |
| US60/710,705 | 2005-08-23 | ||
| PCT/US2005/040919 WO2006110185A2 (fr) | 2004-11-12 | 2005-11-11 | Lipopeptides anti-infectieux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2587848A1 true CA2587848A1 (fr) | 2006-10-19 |
Family
ID=37087468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002587848A Abandoned CA2587848A1 (fr) | 2004-11-12 | 2005-11-11 | Lipopeptides anti-infectieux |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1814588A2 (fr) |
| JP (1) | JP2008519848A (fr) |
| KR (1) | KR20070086038A (fr) |
| AU (1) | AU2005330517A1 (fr) |
| BR (1) | BRPI0517830A (fr) |
| CA (1) | CA2587848A1 (fr) |
| IL (1) | IL183109A0 (fr) |
| NO (1) | NO20072634L (fr) |
| RU (1) | RU2007121705A (fr) |
| WO (1) | WO2006110185A2 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2379580E (pt) * | 2008-12-22 | 2014-01-20 | Cubist Pharm Inc | Novos agentes antibacterianos para o tratamento de infecções por bactérias gram positivas |
| KR20140037877A (ko) * | 2011-05-26 | 2014-03-27 | 큐비스트 파마슈티컬즈 인코포레이티드 | Cb-183,315 조성물 및 관련 방법 |
| KR101723649B1 (ko) | 2014-10-23 | 2017-04-06 | 서울대학교산학협력단 | 신규한 펩티드 화합물, 이의 생산 방법, 및 이의 용도 |
| CN113061164B (zh) * | 2021-03-29 | 2023-01-10 | 四川大学 | 环脂肽类化合物及其在抗类风湿关节炎药物中的应用 |
| WO2023152229A1 (fr) * | 2022-02-09 | 2023-08-17 | Teitur Trophics Aps | Nouveaux peptides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7408025B2 (en) * | 1999-12-15 | 2008-08-05 | Cubist Pharmaceuticals, Inc. | Lipopeptides as antibacterial agents |
| KR20020063227A (ko) * | 1999-12-15 | 2002-08-01 | 큐비스트 파마슈티컬즈 인코포레이티드 | 항균제로서 신규한 리포펩티드 |
| AU784942B2 (en) * | 1999-12-15 | 2006-08-03 | Cubist Pharmaceuticals, Inc. | Daptomycin analogs and their use as antibacterial agents |
| CA2456552A1 (fr) * | 2001-08-06 | 2003-02-20 | Cubist Pharmaceuticals, Inc. | Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine |
| EP1423414A4 (fr) * | 2001-08-06 | 2005-11-30 | Cubist Pharm Inc | Nouveaux depsipeptides et leur procede de preparation |
-
2005
- 2005-11-11 CA CA002587848A patent/CA2587848A1/fr not_active Abandoned
- 2005-11-11 BR BRPI0517830-4A patent/BRPI0517830A/pt not_active IP Right Cessation
- 2005-11-11 JP JP2007541346A patent/JP2008519848A/ja not_active Withdrawn
- 2005-11-11 EP EP05857738A patent/EP1814588A2/fr not_active Withdrawn
- 2005-11-11 RU RU2007121705/04A patent/RU2007121705A/ru not_active Application Discontinuation
- 2005-11-11 KR KR1020077013150A patent/KR20070086038A/ko not_active Application Discontinuation
- 2005-11-11 WO PCT/US2005/040919 patent/WO2006110185A2/fr active Application Filing
- 2005-11-11 AU AU2005330517A patent/AU2005330517A1/en not_active Abandoned
-
2007
- 2007-05-10 IL IL183109A patent/IL183109A0/en unknown
- 2007-05-24 NO NO20072634A patent/NO20072634L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005330517A1 (en) | 2006-10-19 |
| WO2006110185A3 (fr) | 2007-10-25 |
| BRPI0517830A (pt) | 2008-10-21 |
| AU2005330517A2 (en) | 2006-10-19 |
| JP2008519848A (ja) | 2008-06-12 |
| NO20072634L (no) | 2007-08-09 |
| IL183109A0 (en) | 2008-04-13 |
| RU2007121705A (ru) | 2008-12-20 |
| WO2006110185A2 (fr) | 2006-10-19 |
| EP1814588A2 (fr) | 2007-08-08 |
| KR20070086038A (ko) | 2007-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |