CA2585557A1 - Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors - Google Patents

Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors Download PDF

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Publication number
CA2585557A1
CA2585557A1 CA002585557A CA2585557A CA2585557A1 CA 2585557 A1 CA2585557 A1 CA 2585557A1 CA 002585557 A CA002585557 A CA 002585557A CA 2585557 A CA2585557 A CA 2585557A CA 2585557 A1 CA2585557 A1 CA 2585557A1
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Prior art keywords
inhibitors
pde
pyrazolo
pyrimidine derivatives
derivatives useful
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CA002585557A
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French (fr)
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CA2585557C (en
Inventor
Brad Alan Acker
Robert Owen Hughes
Eric John Jacobsen
Hwang-Fun Lu
Thomas Edward Rogers
Michael Brent Tollefson
John Keith Walker
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Pharmacia and Upjohn Co LLC
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

This invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and R5 and R6 are as described herein,which are cyclic guanylate monophosphate (cGMP)-specific phosphodiesterase type 5 inhibitors (PDE-5 inhibitors) that are useful in the treatment of hypertension and other disorders, to processes for their preparation, intermediates used in their preparation, to compositions containing them and the uses of said compounds and compositions.
CA002585557A 2004-10-28 2005-10-17 Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors Expired - Fee Related CA2585557C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62294104P 2004-10-28 2004-10-28
US60/622,941 2004-10-28
PCT/IB2005/003326 WO2006046135A2 (en) 2004-10-28 2005-10-17 Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors

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Publication Number Publication Date
CA2585557A1 true CA2585557A1 (en) 2006-05-04
CA2585557C CA2585557C (en) 2009-08-18

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CA002585557A Expired - Fee Related CA2585557C (en) 2004-10-28 2005-10-17 Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors

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EP (1) EP1809632A2 (en)
JP (1) JP2008517994A (en)
CA (1) CA2585557C (en)
WO (1) WO2006046135A2 (en)

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* Cited by examiner, † Cited by third party
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NZ564187A (en) 2005-05-12 2010-03-26 Pfizer Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
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