WO2006046135A3 - Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors - Google Patents

Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors Download PDF

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Publication number
WO2006046135A3
WO2006046135A3 PCT/IB2005/003326 IB2005003326W WO2006046135A3 WO 2006046135 A3 WO2006046135 A3 WO 2006046135A3 IB 2005003326 W IB2005003326 W IB 2005003326W WO 2006046135 A3 WO2006046135 A3 WO 2006046135A3
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WIPO (PCT)
Prior art keywords
inhibitors
pde
pyrazolo
pyrimidine derivatives
derivatives useful
Prior art date
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PCT/IB2005/003326
Other languages
French (fr)
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WO2006046135A2 (en
Inventor
Brad Alan Acker
Robert Owen Hughes
Eric John Jacobsen
Hwang-Fun Lu
Thomas Edward Rogers
Michael Brent Tollefson
John Keith Walker
Original Assignee
Pharmacia & Upjohn Co Llc
Brad Alan Acker
Robert Owen Hughes
Eric John Jacobsen
Hwang-Fun Lu
Thomas Edward Rogers
Michael Brent Tollefson
John Keith Walker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pharmacia & Upjohn Co Llc, Brad Alan Acker, Robert Owen Hughes, Eric John Jacobsen, Hwang-Fun Lu, Thomas Edward Rogers, Michael Brent Tollefson, John Keith Walker filed Critical Pharmacia & Upjohn Co Llc
Priority to JP2007538544A priority Critical patent/JP2008517994A/en
Priority to EP05800579A priority patent/EP1809632A2/en
Priority to CA002585557A priority patent/CA2585557C/en
Publication of WO2006046135A2 publication Critical patent/WO2006046135A2/en
Publication of WO2006046135A3 publication Critical patent/WO2006046135A3/en

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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Abstract

This invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and R5 and R6 are as described herein,which are cyclic guanylate monophosphate (cGMP)-specific phosphodiesterase type 5 inhibitors (PDE-5 inhibitors) that are useful in the treatment of hypertension and other disorders, to processes for their preparation, intermediates used in their preparation, to compositions containing them and the uses of said compounds and compositions.
PCT/IB2005/003326 2004-10-28 2005-10-17 Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors WO2006046135A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007538544A JP2008517994A (en) 2004-10-28 2005-10-17 New drug
EP05800579A EP1809632A2 (en) 2004-10-28 2005-10-17 Pyrazolo[4,3-d]pyrimidine derivatives useful as pde-5 inhibitors
CA002585557A CA2585557C (en) 2004-10-28 2005-10-17 Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62294104P 2004-10-28 2004-10-28
US60/622,941 2004-10-28

Publications (2)

Publication Number Publication Date
WO2006046135A2 WO2006046135A2 (en) 2006-05-04
WO2006046135A3 true WO2006046135A3 (en) 2006-08-17

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PCT/IB2005/003326 WO2006046135A2 (en) 2004-10-28 2005-10-17 Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors

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EP (1) EP1809632A2 (en)
JP (1) JP2008517994A (en)
CA (1) CA2585557C (en)
WO (1) WO2006046135A2 (en)

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US8227475B2 (en) 2005-05-12 2012-07-24 Pfizer Inc. Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
NL2000291C2 (en) 2005-11-10 2009-02-17 Pfizer Prod Inc 1- (1- (2-ethoxyethyl) -3-ethyl-7- (4-methylpyridin-2-ylamino) -1 H -pyrazole (4,3-d) pyrimidin-5-yl) piperidine-4-carboxylic acid and salts thereof.
ES2310144B1 (en) 2007-06-15 2010-01-12 Galenicum Health, S.L. INTERMEDIATES FOR THE PREPARATION OF A TYPE 5 PHOSPHODIESTERASE INHIBITOR.
EP2646443B1 (en) 2010-12-01 2014-09-24 Pfizer Inc Kat ii inhibitors
EP2809659A1 (en) 2012-02-03 2014-12-10 Basf Se Fungicidal pyrimidine compounds
US9462809B2 (en) 2012-03-13 2016-10-11 Basf Se Fungicidal pyrimidine compounds
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