CA2583575A1 - Measurement of vaporized h2o2 using near infrared spectroscopy for sterilization - Google Patents
Measurement of vaporized h2o2 using near infrared spectroscopy for sterilization Download PDFInfo
- Publication number
- CA2583575A1 CA2583575A1 CA 2583575 CA2583575A CA2583575A1 CA 2583575 A1 CA2583575 A1 CA 2583575A1 CA 2583575 CA2583575 CA 2583575 CA 2583575 A CA2583575 A CA 2583575A CA 2583575 A1 CA2583575 A1 CA 2583575A1
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen peroxide
- near infrared
- vapor
- sterilization
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/208—Hydrogen peroxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Measurements of concentrations of hydrogen peroxide vapor in the presence of water vapor is made using near infrared (NIR) spectroscopy with fiber optic cables to transmit infrared radiation between, e.g, a sterilization chamber and the NIR
instrument.
Hydrogen peroxide absorbs selectively at about 1420 nm, where water vapor also absorbs, but the absorbance at 1420 nm can be corrected for water vapor measurements at remote wavelengths where H202 is transparent. The measurement process also may be incorporated into a control system assuring optimum hydrogen peroxide vapor concentrations for the sterilization procedure.
instrument.
Hydrogen peroxide absorbs selectively at about 1420 nm, where water vapor also absorbs, but the absorbance at 1420 nm can be corrected for water vapor measurements at remote wavelengths where H202 is transparent. The measurement process also may be incorporated into a control system assuring optimum hydrogen peroxide vapor concentrations for the sterilization procedure.
Claims (2)
1. A method of determining the concentration of hydrogen peroxide vapor in the presence of water vapor in an unknown sample containing both hydrogen peroxide and water vapors comprising:
a) measuring the near infrared spectrum of a series of calibration samples containing known concentrations of hydrogen peroxide vapor, water vapor, and combinations thereof over at least one band within the region from about 900 to about 2000 nanometers, said band including 1420 nm;
b) analyzing the measured spectra and the known concentrations in the calibration set to produce a correlation between the measured near infrared spectrum and the concentration of hydrogen peroxide;
c) measuring the near infrared absorbance spectrum of said unknown sample over the said band within the region from about 900 to about 2000 nanometers; and d) applying the correlation of step b) to the near infrared spectrum of the unknown sample to determine the concentration of hydrogen peroxide vapor therein.
a) measuring the near infrared spectrum of a series of calibration samples containing known concentrations of hydrogen peroxide vapor, water vapor, and combinations thereof over at least one band within the region from about 900 to about 2000 nanometers, said band including 1420 nm;
b) analyzing the measured spectra and the known concentrations in the calibration set to produce a correlation between the measured near infrared spectrum and the concentration of hydrogen peroxide;
c) measuring the near infrared absorbance spectrum of said unknown sample over the said band within the region from about 900 to about 2000 nanometers; and d) applying the correlation of step b) to the near infrared spectrum of the unknown sample to determine the concentration of hydrogen peroxide vapor therein.
2. A method of sterilization of an inanimate object containing microorganisms comprising:
a) placing the object in a sterilization chamber;
b) injecting a sterilization agent comprising hydrogen peroxide into the sterilization chamber in an amount sufficient to produce a concentration of hydrogen peroxide and water vapors in the headspace of the chamber;
c) measuring the concentration of hydrogen peroxide vapor in the headspace using the method of Claims 1; and d) comparing the measured amount from step c) with the target amount necessary for complete destruction of all microorganisms in the object; and e) repeating steps b), c) and d) if the comparison of step d) is less than the target amount.
a) placing the object in a sterilization chamber;
b) injecting a sterilization agent comprising hydrogen peroxide into the sterilization chamber in an amount sufficient to produce a concentration of hydrogen peroxide and water vapors in the headspace of the chamber;
c) measuring the concentration of hydrogen peroxide vapor in the headspace using the method of Claims 1; and d) comparing the measured amount from step c) with the target amount necessary for complete destruction of all microorganisms in the object; and e) repeating steps b), c) and d) if the comparison of step d) is less than the target amount.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US451,842 | 1995-05-26 | ||
| US08/451,842 US5600142A (en) | 1995-05-26 | 1995-05-26 | Measurement of vaporized hydrogen peroxide |
| CA002176993A CA2176993C (en) | 1995-05-26 | 1996-05-21 | Measurement of vaporized h2o2 using near infrared spectroscopy for sterilization |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002176993A Division CA2176993C (en) | 1995-05-26 | 1996-05-21 | Measurement of vaporized h2o2 using near infrared spectroscopy for sterilization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2583575A1 true CA2583575A1 (en) | 1996-11-27 |
| CA2583575C CA2583575C (en) | 2010-09-07 |
Family
ID=38227688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2583575 Expired - Lifetime CA2583575C (en) | 1995-05-26 | 1996-05-21 | Measurement of vaporized h2o2 using near infrared spectroscopy for sterilization |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2583575C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109720658A (en) * | 2018-11-27 | 2019-05-07 | 上海翡诺医药设备有限公司 | A kind of hydrogen peroxide vacuum and low temperature disinfection system and method |
| CN114486805A (en) * | 2020-10-23 | 2022-05-13 | 中国石油化工股份有限公司 | Method for determining process parameters of hydrogen peroxide production process |
-
1996
- 1996-05-21 CA CA 2583575 patent/CA2583575C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109720658A (en) * | 2018-11-27 | 2019-05-07 | 上海翡诺医药设备有限公司 | A kind of hydrogen peroxide vacuum and low temperature disinfection system and method |
| CN114486805A (en) * | 2020-10-23 | 2022-05-13 | 中国石油化工股份有限公司 | Method for determining process parameters of hydrogen peroxide production process |
| CN114486805B (en) * | 2020-10-23 | 2024-01-05 | 中国石油化工股份有限公司 | Method for determining process parameters of hydrogen peroxide production process |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2583575C (en) | 2010-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20160524 |