CA2580679A1 - Variants and chemically-modified variants of phenylalanine ammonia-lyase - Google Patents
Variants and chemically-modified variants of phenylalanine ammonia-lyase Download PDFInfo
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- CA2580679A1 CA2580679A1 CA002580679A CA2580679A CA2580679A1 CA 2580679 A1 CA2580679 A1 CA 2580679A1 CA 002580679 A CA002580679 A CA 002580679A CA 2580679 A CA2580679 A CA 2580679A CA 2580679 A1 CA2580679 A1 CA 2580679A1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Microbiology (AREA)
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- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61077004P | 2004-09-17 | 2004-09-17 | |
| US60/610,770 | 2004-09-17 | ||
| US65195005P | 2005-02-09 | 2005-02-09 | |
| US60/651,950 | 2005-02-09 | ||
| PCT/US2005/033895 WO2006034373A2 (en) | 2004-09-17 | 2005-09-19 | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
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|---|---|
| CA2580679A1 true CA2580679A1 (en) | 2006-03-30 |
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|---|---|---|---|
| CA002580679A Abandoned CA2580679A1 (en) | 2004-09-17 | 2005-09-19 | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
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| US (1) | US7553653B2 (enExample) |
| EP (1) | EP1814984A2 (enExample) |
| JP (1) | JP2008513027A (enExample) |
| AU (1) | AU2005286763A1 (enExample) |
| CA (1) | CA2580679A1 (enExample) |
| WO (1) | WO2006034373A2 (enExample) |
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| MXPA06005451A (es) | 2003-11-17 | 2007-01-26 | Biomarin Pharm Inc | Metodos y composiciones para el tratamiento de trastornos metabolicos. |
| US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| WO2008070117A1 (en) * | 2006-12-04 | 2008-06-12 | Promedior, Inc. | Conjoint therapy for treating fibrotic diseases |
| CA2682598C (en) | 2007-04-11 | 2016-06-07 | Biomarin Pharmaceutical Inc. | Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring |
| US8497243B2 (en) * | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
| US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
| US7537923B2 (en) | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
| US20110201022A1 (en) * | 2008-07-30 | 2011-08-18 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
| WO2010104959A1 (en) * | 2009-03-11 | 2010-09-16 | Promedior, Inc. | Treatment and diagnostic methods for hypersensitive disorders |
| CA2755047C (en) * | 2009-03-11 | 2018-12-04 | Promedior, Inc. | Treatment methods for autoimmune disorders |
| UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
| AU2010262847B2 (en) | 2009-06-17 | 2016-06-02 | Promedior, Inc. | SAP variants and their use |
| SI3025728T1 (sl) | 2010-02-04 | 2018-11-30 | Biomarin Pharmaceutical Inc. | Metoda za čiščenje prokariontskih fenilalanin amonij-liaznih variant |
| CN105061534A (zh) | 2010-09-22 | 2015-11-18 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
| HK1203075A1 (en) | 2011-12-22 | 2015-10-16 | 艾丽奥斯生物制药有限公司 | Substituted phosphorothioate nucleotide analogs |
| EP2828277A1 (en) | 2012-03-21 | 2015-01-28 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| EP2877584A4 (en) | 2012-07-26 | 2016-03-30 | Casa Luker S A | METHODS FOR INCREASING THE PRODUCTION OF PHENOLIC COMPOUNDS FROM THEBROMA COCOA |
| ES2890955T3 (es) | 2013-04-18 | 2022-01-25 | Codexis Inc | Polipéptidos de fenilalanina amoníaco liasa modificados |
| CA2943432A1 (en) | 2014-04-16 | 2015-10-22 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| CA2985819A1 (en) | 2015-05-13 | 2016-11-17 | Synlogic, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3807409A4 (en) | 2018-06-12 | 2022-08-03 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| US11198861B2 (en) | 2018-07-12 | 2021-12-14 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
| JP2022513199A (ja) | 2018-12-14 | 2022-02-07 | コデクシス, インコーポレイテッド | 操作されたチロシンアンモニアリアーゼ |
| KR20220103944A (ko) * | 2019-10-17 | 2022-07-25 | 이케나 온콜로지, 인코포레이티드 | Peg화 키뉴레니나제 효소 및 암 치료를 위한 그의 용도 |
| BR112022015139A2 (pt) | 2020-02-04 | 2022-10-11 | Codexis Inc | Polipeptídeo da leucina descarboxilase engenheirada, composição, sequência de polinucleotídeo engenheirado, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo da leucina descarboxilase engenheirada e para tratar e/ou prevenir os sintomas de doença da urina de xarope de bordo, composição, e, uso |
| JP2023518184A (ja) * | 2020-03-20 | 2023-04-28 | シンロジック オペレーティング カンパニー インコーポレイテッド | 高フェニルアラニン血症を軽減するように遺伝子改変された微生物 |
| JP2023539632A (ja) | 2020-08-28 | 2023-09-15 | コデクシス, インコーポレイテッド | 操作されたプロテアーゼバリアント |
| CA3191900A1 (en) | 2020-08-28 | 2022-03-03 | Codexis, Inc. | Engineered amylase variants |
| CN118931888A (zh) * | 2023-05-09 | 2024-11-12 | 重庆派金生物科技有限公司 | 苯丙氨酸裂解酶突变体及其偶联物或其药学上可接受的盐 |
| US20250108095A1 (en) * | 2023-09-28 | 2025-04-03 | Aperiam Bio, Inc. | Degradation of toxins in vivo |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562151A (en) * | 1983-09-06 | 1985-12-31 | Monsanto Company | Stabilization of L-phenylalanine ammonia-lyase enzyme |
| US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| DK75593D0 (enExample) * | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
| US5981239A (en) * | 1997-09-24 | 1999-11-09 | Great Lakes Chemical Corp. | Synthesis of optically active phenylalanine analogs using Rhodotorula graminis |
| US6451986B1 (en) * | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| US6461849B1 (en) * | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
| US6686164B1 (en) * | 1998-10-30 | 2004-02-03 | Novozymes A/S | Low allergenic protein variants |
| AU772153B2 (en) * | 1999-02-12 | 2004-04-08 | Molecular Insight Pharmaceuticals, Inc. | Matrices for drug delivery and methods for making and using the same |
| US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| EP1280924A2 (en) * | 2000-04-14 | 2003-02-05 | University of South Carolina Research Foundation | Cloning of corynebacteriaceae histidine ammonia lyase and therapeutic uses |
| US6967097B2 (en) * | 2000-07-24 | 2005-11-22 | Pcbu Services, Inc. | Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same |
| KR20040088538A (ko) | 2002-02-26 | 2004-10-16 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 유전 인자의 재조합 방법 |
| CA2506026A1 (en) | 2002-11-14 | 2004-05-27 | The Scripps Research Institute | Crystalline form of fatty acid amine hydrolase (faah) |
-
2005
- 2005-09-19 AU AU2005286763A patent/AU2005286763A1/en not_active Abandoned
- 2005-09-19 CA CA002580679A patent/CA2580679A1/en not_active Abandoned
- 2005-09-19 US US11/230,374 patent/US7553653B2/en not_active Expired - Fee Related
- 2005-09-19 JP JP2007532656A patent/JP2008513027A/ja active Pending
- 2005-09-19 WO PCT/US2005/033895 patent/WO2006034373A2/en not_active Ceased
- 2005-09-19 EP EP05816095A patent/EP1814984A2/en not_active Withdrawn
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|---|---|
| US20070048855A1 (en) | 2007-03-01 |
| WO2006034373A2 (en) | 2006-03-30 |
| EP1814984A2 (en) | 2007-08-08 |
| WO2006034373A3 (en) | 2006-11-02 |
| WO2006034373A8 (en) | 2006-08-10 |
| JP2008513027A (ja) | 2008-05-01 |
| US7553653B2 (en) | 2009-06-30 |
| WO2006034373A9 (en) | 2006-05-11 |
| AU2005286763A1 (en) | 2006-03-30 |
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