CA2564311A1 - Ligands d'acide nucleique specifiques de l'immunoglobuline et leur utilisation comme agents therapeutiques pour des maladies atopiques - Google Patents

Ligands d'acide nucleique specifiques de l'immunoglobuline et leur utilisation comme agents therapeutiques pour des maladies atopiques Download PDF

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Publication number
CA2564311A1
CA2564311A1 CA002564311A CA2564311A CA2564311A1 CA 2564311 A1 CA2564311 A1 CA 2564311A1 CA 002564311 A CA002564311 A CA 002564311A CA 2564311 A CA2564311 A CA 2564311A CA 2564311 A1 CA2564311 A1 CA 2564311A1
Authority
CA
Canada
Prior art keywords
aptamer
ome
seq
ige
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002564311A
Other languages
English (en)
Inventor
Sharon Cload
John L. Diener
Sara Chesworth Keene
Markus Kurz
H. A. Daniel Lagasse
Harold Nicholas Marsh
Pooja Sawhney
Paula Burmeister
Anthony Dominic Keefe
Chunhua Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Archemix Corp
Original Assignee
Sharon Cload
John L. Diener
Sara Chesworth Keene
Markus Kurz
H. A. Daniel Lagasse
Harold Nicholas Marsh
Pooja Sawhney
Paula Burmeister
Anthony Dominic Keefe
Chunhua Wang
Archemix Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sharon Cload, John L. Diener, Sara Chesworth Keene, Markus Kurz, H. A. Daniel Lagasse, Harold Nicholas Marsh, Pooja Sawhney, Paula Burmeister, Anthony Dominic Keefe, Chunhua Wang, Archemix Corp. filed Critical Sharon Cload
Publication of CA2564311A1 publication Critical patent/CA2564311A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/331—Universal or degenerate base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
CA002564311A 2004-04-26 2005-04-26 Ligands d'acide nucleique specifiques de l'immunoglobuline et leur utilisation comme agents therapeutiques pour des maladies atopiques Abandoned CA2564311A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US56560104P 2004-04-26 2004-04-26
US60/565,601 2004-04-26
US57412004P 2004-05-24 2004-05-24
US60/574,120 2004-05-24
US58186504P 2004-06-22 2004-06-22
US60/581,865 2004-06-22
US66020405P 2005-03-07 2005-03-07
US60/660,204 2005-03-07
PCT/US2005/014361 WO2005113813A2 (fr) 2004-04-26 2005-04-26 Ligands d'acide nucleique specifiques de l'immunoglobuline et leur utilisation comme agents therapeutiques pour des maladies atopiques

Publications (1)

Publication Number Publication Date
CA2564311A1 true CA2564311A1 (fr) 2005-12-01

Family

ID=35428939

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002564311A Abandoned CA2564311A1 (fr) 2004-04-26 2005-04-26 Ligands d'acide nucleique specifiques de l'immunoglobuline et leur utilisation comme agents therapeutiques pour des maladies atopiques

Country Status (6)

Country Link
EP (1) EP1742959A2 (fr)
JP (1) JP2007534339A (fr)
KR (1) KR20070044813A (fr)
AU (1) AU2005245793A1 (fr)
CA (1) CA2564311A1 (fr)
WO (1) WO2005113813A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5135578B2 (ja) * 2007-02-20 2013-02-06 国立大学法人金沢大学 磁気共鳴測定装置、集積回路および磁気共鳴測定方法
CN104388424B (zh) * 2011-07-04 2017-07-07 日本电气方案创新株式会社 评价核酸分子的氧化还原活性的方法和具有氧化还原活性的核酸分子
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766853A (en) * 1990-06-11 1998-06-16 Nexstar Pharmaceuticals, Inc. Method for identification of high affinity nucleic acid ligands to selectins
US5629155A (en) * 1990-06-11 1997-05-13 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to immunoglobulin E (IgE)
JP2002515514A (ja) * 1998-05-21 2002-05-28 アイシス・ファーマシューティカルス・インコーポレーテッド オリゴヌクレオチドの局所送逹のための組成物及び方法
WO2003102212A2 (fr) * 2002-05-31 2003-12-11 Regents Of The University Of Minnesota Evolution in vitro d'arn et d'adn fonctionnels utilisant la selection electrophoretique
AU2003247576A1 (en) * 2002-06-18 2003-12-31 Archemix Corp. Aptamer-toxin molecules and methods for using same
US20040110235A1 (en) * 2002-07-25 2004-06-10 David Epstein Regulated aptamer therapeutics
US9303262B2 (en) * 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators

Also Published As

Publication number Publication date
EP1742959A2 (fr) 2007-01-17
WO2005113813A3 (fr) 2006-08-24
WO2005113813A2 (fr) 2005-12-01
AU2005245793A2 (en) 2008-08-28
JP2007534339A (ja) 2007-11-29
WO2005113813A8 (fr) 2006-03-09
AU2005245793A1 (en) 2005-12-01
KR20070044813A (ko) 2007-04-30

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Legal Events

Date Code Title Description
FZDE Discontinued