CA2561952A1 - Use of 5,10-methylene tetrahydrofolate for the treatment of cancer - Google Patents
Use of 5,10-methylene tetrahydrofolate for the treatment of cancer Download PDFInfo
- Publication number
- CA2561952A1 CA2561952A1 CA002561952A CA2561952A CA2561952A1 CA 2561952 A1 CA2561952 A1 CA 2561952A1 CA 002561952 A CA002561952 A CA 002561952A CA 2561952 A CA2561952 A CA 2561952A CA 2561952 A1 CA2561952 A1 CA 2561952A1
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- Prior art keywords
- cancer
- anticancer drug
- additional anticancer
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- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55888904P | 2004-04-02 | 2004-04-02 | |
| US60/558,889 | 2004-04-02 | ||
| US62547904P | 2004-11-04 | 2004-11-04 | |
| US60/625,479 | 2004-11-04 | ||
| US65874505P | 2005-03-04 | 2005-03-04 | |
| US60/658,745 | 2005-03-04 | ||
| PCT/US2005/011046 WO2005097086A2 (en) | 2004-04-02 | 2005-04-01 | Use of 5,10-methylene tetrahydrofolate for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2561952A1 true CA2561952A1 (en) | 2005-10-20 |
Family
ID=35125596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002561952A Abandoned CA2561952A1 (en) | 2004-04-02 | 2005-04-01 | Use of 5,10-methylene tetrahydrofolate for the treatment of cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070280944A1 (https=) |
| EP (1) | EP1740182A2 (https=) |
| JP (1) | JP2007531728A (https=) |
| AU (1) | AU2005231436A1 (https=) |
| CA (1) | CA2561952A1 (https=) |
| IL (1) | IL178261A0 (https=) |
| WO (1) | WO2005097086A2 (https=) |
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|---|---|---|---|---|
| US8871279B2 (en) * | 2000-03-09 | 2014-10-28 | Yale University | Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen |
| CN101657203B (zh) * | 2007-03-02 | 2012-09-05 | 卧龙岗大学 | 抗癌药的组合物及递送方法 |
| WO2008109349A1 (en) * | 2007-03-06 | 2008-09-12 | Adventrx Pharmaceuticals, Inc. | Improved regimen for treating cancer with 5-fluorouracil, 5,10-methylenetetrahydrofolate and capecitabine |
| US9463193B2 (en) * | 2008-09-26 | 2016-10-11 | Institut De Cancerologie De L'ouest | Individual 5-fluorouracile dose optimization in folfiri treatment |
| AU2008362108B2 (en) * | 2008-09-26 | 2015-09-03 | Institut De Cancerologie De L'ouest | Individual 5-fluorouracile dose optimization in FOLFOX treatment |
| EP2617422A1 (en) * | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Anti-tumor activity of reduced folates like methylene-tetrahydrofolate, tetrahydrofolate or methyl-tetrahydrofolate |
| EP2617421A1 (en) * | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
| WO2018065445A1 (en) * | 2016-10-05 | 2018-04-12 | Isofol Medical Ab | [6r]-mthf multiple bolus administration in 5-fluorouracil based chemotherapy |
| EP3305318A1 (en) * | 2016-10-05 | 2018-04-11 | Isofol Medical AB | [6r]-5,10-methylenetetrahydrofolate in 5-fluorouracil based chemotherapy |
| WO2018065446A1 (en) * | 2016-10-05 | 2018-04-12 | Isofol Medical Ab | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| EP3446704A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| EP3446703A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | 6r]-mthf multiple bolus administration in 5-fluorouracil based chemotherapy |
| US10292984B2 (en) | 2017-02-14 | 2019-05-21 | Isofol Medical Ab | Methods for increasing blood plasma 2′-deoxyuridine (dUrd) and thymidylate synthase inhibition |
| JP7258759B2 (ja) * | 2018-01-05 | 2023-04-17 | アイソフォル・メディカル・エービー | 大腸癌及び転移性大腸癌を治療する方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376658A (en) * | 1990-05-11 | 1994-12-27 | University Of Southern California | 5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent |
| US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
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2005
- 2005-04-01 JP JP2007506303A patent/JP2007531728A/ja active Pending
- 2005-04-01 WO PCT/US2005/011046 patent/WO2005097086A2/en not_active Ceased
- 2005-04-01 CA CA002561952A patent/CA2561952A1/en not_active Abandoned
- 2005-04-01 US US10/594,850 patent/US20070280944A1/en not_active Abandoned
- 2005-04-01 AU AU2005231436A patent/AU2005231436A1/en not_active Abandoned
- 2005-04-01 EP EP05732160A patent/EP1740182A2/en not_active Withdrawn
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2006
- 2006-09-21 IL IL178261A patent/IL178261A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005231436A1 (en) | 2005-10-20 |
| WO2005097086A3 (en) | 2006-05-18 |
| WO2005097086A2 (en) | 2005-10-20 |
| US20070280944A1 (en) | 2007-12-06 |
| JP2007531728A (ja) | 2007-11-08 |
| IL178261A0 (en) | 2006-12-31 |
| EP1740182A2 (en) | 2007-01-10 |
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