CA2555661C - Fusion proteins containing recombinant cytotoxic rnases - Google Patents

Fusion proteins containing recombinant cytotoxic rnases Download PDF

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Publication number
CA2555661C
CA2555661C CA2555661A CA2555661A CA2555661C CA 2555661 C CA2555661 C CA 2555661C CA 2555661 A CA2555661 A CA 2555661A CA 2555661 A CA2555661 A CA 2555661A CA 2555661 C CA2555661 C CA 2555661C
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Prior art keywords
virus
immunotoxin
domain
antibody
ranpirnase
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Expired - Fee Related
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CA2555661A
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English (en)
French (fr)
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CA2555661A1 (en
Inventor
David M. Goldenberg
Hans J. Hansen
Chien-Hsing Ken Chang
Sailaja S. Vanama
Edmund A. Rossi
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Immunomedics Inc
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Immunomedics Inc
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Publication of CA2555661A1 publication Critical patent/CA2555661A1/en
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Publication of CA2555661C publication Critical patent/CA2555661C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2510/00—Genetically modified cells
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CA2555661A 2004-02-13 2005-02-14 Fusion proteins containing recombinant cytotoxic rnases Expired - Fee Related CA2555661C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54422704P 2004-02-13 2004-02-13
US60/544,227 2004-02-13
PCT/US2005/004860 WO2005080586A1 (en) 2004-02-13 2005-02-14 Fusion proteins containing recombinant cytotoxic rnases

Publications (2)

Publication Number Publication Date
CA2555661A1 CA2555661A1 (en) 2005-09-01
CA2555661C true CA2555661C (en) 2017-11-21

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CA2555661A Expired - Fee Related CA2555661C (en) 2004-02-13 2005-02-14 Fusion proteins containing recombinant cytotoxic rnases

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