CA2554880A1 - Methods and compositions for modulating angiogenesis - Google Patents

Methods and compositions for modulating angiogenesis Download PDF

Info

Publication number
CA2554880A1
CA2554880A1 CA002554880A CA2554880A CA2554880A1 CA 2554880 A1 CA2554880 A1 CA 2554880A1 CA 002554880 A CA002554880 A CA 002554880A CA 2554880 A CA2554880 A CA 2554880A CA 2554880 A1 CA2554880 A1 CA 2554880A1
Authority
CA
Canada
Prior art keywords
ccx
agent
ckr2
cells
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002554880A
Other languages
English (en)
French (fr)
Inventor
Jennifer M. Burns
Bretton Summers
Yu Wang
Maureen Howard
Thomas Schall
Zhenhua Miao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemocentryx Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2554880A1 publication Critical patent/CA2554880A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/195Chemokines, e.g. RANTES
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002554880A 2004-02-03 2005-02-02 Methods and compositions for modulating angiogenesis Abandoned CA2554880A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US54184904P 2004-02-03 2004-02-03
US60/541,849 2004-02-03
US59895804P 2004-08-04 2004-08-04
US60/598,958 2004-08-04
US62619504P 2004-11-08 2004-11-08
US60/626,195 2004-11-08
PCT/US2005/003521 WO2005074645A2 (en) 2004-02-03 2005-02-02 Methods and compositions for modulating angiogenesis

Publications (1)

Publication Number Publication Date
CA2554880A1 true CA2554880A1 (en) 2005-08-18

Family

ID=34841735

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002554880A Abandoned CA2554880A1 (en) 2004-02-03 2005-02-02 Methods and compositions for modulating angiogenesis

Country Status (7)

Country Link
US (1) US20050214287A1 (enExample)
EP (1) EP1715892A4 (enExample)
JP (1) JP4916889B2 (enExample)
AU (1) AU2005209921B2 (enExample)
CA (1) CA2554880A1 (enExample)
IL (1) IL177104A (enExample)
WO (1) WO2005074645A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7417062B2 (en) 2004-09-29 2008-08-26 Chemocentryx, Inc. Substituted arylamides
CA2613545A1 (en) * 2005-06-29 2007-01-04 Chemocentryx, Inc. Substituted n-cinnamyl benzamides
US8088895B2 (en) * 2006-10-18 2012-01-03 Chemocentryx, Inc. Antibodies that bind CXCR7 epitopes
JP2009091339A (ja) * 2007-10-12 2009-04-30 Seikagaku Kogyo Co Ltd 関節リウマチの処置剤
JP5785089B2 (ja) * 2008-11-04 2015-09-24 ケモセントリックス,インコーポレイティド Cxcr7の調節因子
US8853202B2 (en) * 2008-11-04 2014-10-07 Chemocentryx, Inc. Modulators of CXCR7
US20110014121A1 (en) * 2008-11-04 2011-01-20 Chemocentryx, Inc. Modulators of cxcr7
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
KR102196374B1 (ko) 2012-11-29 2020-12-31 케모센트릭스, 인크. Cxcr7 길항제
BR112021011222A2 (pt) 2018-12-12 2021-08-24 Chemocentryx, Inc. Inibidores de cxcr7 para o tratamento de câncer
CN111593022B (zh) * 2018-12-27 2023-10-24 广州溯原生物科技股份有限公司 vMIP-Ⅱ诱导CD8+ T细胞去磷酸化为Tcm及其在药物中的应用
AU2022261722A1 (en) 2021-04-19 2023-11-30 Chemocentryx, Inc. Azetidinyl-acetamides as cxcr7 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020166133A1 (en) * 1998-02-10 2002-11-07 Millennium Pharmaceuticals, Inc Neokine protein and nucleic acid molecules and uses therefor
WO1999047158A2 (en) * 1998-03-13 1999-09-23 The University Of British Columbia Therapeutic chemokine receptor antagonists
US20020107196A1 (en) * 1998-07-21 2002-08-08 Smithkline Beecham Corporation Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha
NZ524421A (en) * 2000-09-15 2005-02-25 Anormed Inc Chemokine receptor binding heterocyclic compounds
CN1630517A (zh) * 2001-05-24 2005-06-22 吴羽化学工业株式会社 包含含氮化合物的具有cxcr4拮抗作用的药物
US7253007B2 (en) * 2001-11-30 2007-08-07 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
JP4870357B2 (ja) * 2002-12-20 2012-02-08 ケモセントリックス, インコーポレイテッド ヒト腫瘍発現ccxckr2の阻害剤
WO2004062591A2 (en) * 2003-01-06 2004-07-29 Oregon Health And Science University Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases

Also Published As

Publication number Publication date
IL177104A (en) 2010-12-30
AU2005209921A1 (en) 2005-08-18
IL177104A0 (en) 2006-12-10
US20050214287A1 (en) 2005-09-29
EP1715892A2 (en) 2006-11-02
WO2005074645A2 (en) 2005-08-18
JP2007520564A (ja) 2007-07-26
AU2005209921B2 (en) 2011-04-07
WO2005074645A3 (en) 2005-12-22
JP4916889B2 (ja) 2012-04-18
EP1715892A4 (en) 2008-07-09

Similar Documents

Publication Publication Date Title
US20110165164A1 (en) Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
Struyf et al. Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4
AU2005209921B2 (en) Methods and compositions for modulating angiogenesis
KR20060136373A (ko) 케모카인 수용체와 관련된 질병 및 증상의 검출 및 치료용조성물 및 방법
IL175179A (en) A method of scanning for a factor that links ccx – ckr2 on a cell, and its use to detect the presence or absence of cancer
US20100247540A1 (en) Methods and Compositions For Modulating Angiogenesis
KR101149115B1 (ko) 혈관신생을 조절하기 위한 방법 및 조성물
MXPA06008680A (es) Metodos y composiciones para modular la angiogenesis
Mewar et al. Antibodies to ferritin in rheumatoid arthritis are associated with disease severity
Spachidou et al. Cultured salivary gland epithelial cells from patients with primary Sjögren's syndrome and disease controls are sensitive to signaling via Toll-like receptors 2 and 3: upregulation of intercellular adhesion molecule-1 expression
Adam et al. Toll-like receptor 4 polymorphisms and ankylosing spondylitis
Remans et al. Free radicals regulate glucocorticoid-induced apoptosis in T lymphocytes
Dell'Accio et al. Molecular response to cartilage injury
Svenungsson et al. Endothelial function and activation in women with systemic lupus erythematosus
Fearon et al. Oncostatin M in rheumatoid arthritis: a key cytokine acts synergistically with other proinflammatory cytokines to promote human cartilage loss
Stummvoll et al. Autoreactive T cells to histone H1 and core histones in patients with systemic lupus erythematosus
Smith et al. Rheumatoid synovial fibroblasts activate endothelial cells and promote neutrophil recruitment in a flow based multicellular model of the rheumatoid pannus
Palmer et al. Intracellular IL-1 receptor antagonist (icIL-1Ra1) does not antagonize growth inhibitory effects of pre-IL-1α in SaOS-2 cells
Ali et al. Complement and Fc receptor cross-talk in the Arthus reaction: the inflammatory cascade confirmed and refined
Bertsias et al. Expression of programmed death (PD)-1 and PD-1 ligands (PD-L1, PD-L2) in peripheral blood mononuclear cells of patients with systemic lupus erythematosus
Ranganath Characteristics and outcomes in sero-positive late-onset rheumatoid arthritis patients who start a new disease modifying anti-rheumatic drug
Glocker et al. Molecular signatures of rheumatoid arthritis characterized by transcriptome and proteome analysis
Gerlag et al. Real-time quantitative PCR used as a biomarker for synovial gene expression after oral prednisolone therapy in patients with rheumatoid arthritis
Jongbloed et al. Immunophenotype and functional characteristics of rheumatoid arthritis derived myeloid dendritic cells and plasmacytoid dendritic cells
Adriaansen et al. Intra-articular gene therapy blocking NF-κB using adeno-associated virus type 5 ameliorates adjuvant arthritis in rats

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130129