CA2554797C - 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors - Google Patents
2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors Download PDFInfo
- Publication number
- CA2554797C CA2554797C CA2554797A CA2554797A CA2554797C CA 2554797 C CA2554797 C CA 2554797C CA 2554797 A CA2554797 A CA 2554797A CA 2554797 A CA2554797 A CA 2554797A CA 2554797 C CA2554797 C CA 2554797C
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- Prior art keywords
- alkyl
- phenyl
- hydrogen
- methyl
- alkoxy
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- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title description 5
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title description 5
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 77
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 66
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04002420 | 2004-02-04 | ||
| EP04002420.0 | 2004-02-04 | ||
| PCT/EP2005/050415 WO2005075456A1 (en) | 2004-02-04 | 2005-02-01 | 2-(piperidin-4-yl) -4, 5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2554797A1 CA2554797A1 (en) | 2005-08-18 |
| CA2554797C true CA2554797C (en) | 2012-09-04 |
Family
ID=34833569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2554797A Expired - Fee Related CA2554797C (en) | 2004-02-04 | 2005-02-01 | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7494990B2 (enExample) |
| EP (1) | EP1716133B1 (enExample) |
| JP (1) | JP4778449B2 (enExample) |
| AT (1) | ATE390419T1 (enExample) |
| AU (1) | AU2005210042B2 (enExample) |
| CA (1) | CA2554797C (enExample) |
| DE (1) | DE602005005638T2 (enExample) |
| ES (1) | ES2304692T3 (enExample) |
| WO (1) | WO2005075456A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013234404B2 (en) * | 2007-05-16 | 2016-04-28 | Takeda Gmbh | Pyrazolone Derivatives as PDE4 Inhibitors |
| ME00952B (me) | 2007-05-16 | 2012-06-20 | Takeda Gmbh | Derivati pirazolona kao pde4 inhibitori |
| AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| JP5980318B2 (ja) | 2011-06-17 | 2016-08-31 | タケダ ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ | 新規のフタラジノン−ピロロピリミジンカルボキサミド誘導体 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB858792A (en) * | 1958-02-10 | 1961-01-18 | Sandoz Ltd | New pyridazine derivatives and processes for their manufacture |
| US5267027A (en) * | 1991-04-30 | 1993-11-30 | Sanyo Electric Co., Ltd. | Comb filter-type Y/C separator circuit |
| ATE183745T1 (de) | 1991-10-09 | 1999-09-15 | Syntex Inc | Pyrido pyridazinon und pyridazinthionverbindungen mit pde iv inhibierender wirkung |
| DE4134893A1 (de) | 1991-10-23 | 1993-04-29 | Merck Patent Gmbh | Thiadiazinone |
| DE4310699A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Thiadiazinone |
| US5798349A (en) | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
| DE19502699A1 (de) * | 1995-01-28 | 1996-08-01 | Merck Patent Gmbh | Arylalkyl-thiadiazinone |
| DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
| DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| DE19604388A1 (de) | 1996-02-07 | 1997-08-14 | Merck Patent Gmbh | Arylalkyl-diazinone |
| HUP0001541A3 (en) * | 1997-01-15 | 2001-11-28 | Altana Pharma Ag | Phthalazinone derivatives and pharmaceutical compositions containing them |
| WO1999031071A1 (en) | 1997-12-15 | 1999-06-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New phthalazinones |
| US6380196B1 (en) * | 1997-12-15 | 2002-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurans |
| US6255303B1 (en) * | 1998-03-14 | 2001-07-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone PDE III/IV inhibitors |
| AU7654200A (en) | 1999-09-14 | 2001-04-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pd3/4 inhibitors |
| EP1244654A1 (en) | 1999-10-25 | 2002-10-02 | ALTANA Pharma AG | Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors |
| CA2388121A1 (en) | 1999-10-25 | 2001-05-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pde 4 inhibitors |
| NZ522882A (en) * | 2000-06-05 | 2004-07-30 | Altana Pharma Bv | Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors |
| EA200300836A1 (ru) * | 2001-02-15 | 2004-02-26 | Алтана Фарма Аг | Производные фталазинон-пиперидина в качестве ингибиторов pde4 |
| SK14352003A3 (sk) * | 2001-04-25 | 2004-04-06 | Altana Pharma Ag | Piperazino-deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| PL363312A1 (en) * | 2001-04-25 | 2004-11-15 | Altana Pharma Ag | Novel phthalazinones |
| DE10150517A1 (de) | 2001-10-12 | 2003-04-17 | Merck Patent Gmbh | Verwendung von Phosphodiesterase IV-Inhibitoren |
| JP2005538138A (ja) | 2002-08-10 | 2005-12-15 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４インヒビターとしてのピリダジノン誘導体 |
| KR101131684B1 (ko) * | 2002-08-10 | 2012-03-28 | 니코메드 게엠베하 | Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존 |
| WO2004018449A1 (en) | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| PL373597A1 (en) | 2002-08-10 | 2005-09-05 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| WO2004017957A1 (en) | 2002-08-20 | 2004-03-04 | Protemix Corporation Limited | Preventing and/or treating cardiovascular disease and/or associated heart failure |
| US20080227790A1 (en) | 2004-02-04 | 2008-09-18 | Altana Pharma Ag | Pyridazinone Derivatives and their Use as Pde4 Inhibitors |
| WO2005075457A1 (en) | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Phthalazinone-derivatives as pde4 inhibitors |
-
2005
- 2005-02-01 AU AU2005210042A patent/AU2005210042B2/en not_active Ceased
- 2005-02-01 AT AT05716609T patent/ATE390419T1/de active
- 2005-02-01 CA CA2554797A patent/CA2554797C/en not_active Expired - Fee Related
- 2005-02-01 US US10/587,836 patent/US7494990B2/en not_active Expired - Fee Related
- 2005-02-01 JP JP2006551846A patent/JP4778449B2/ja not_active Expired - Fee Related
- 2005-02-01 DE DE602005005638T patent/DE602005005638T2/de not_active Expired - Lifetime
- 2005-02-01 EP EP05716609A patent/EP1716133B1/en not_active Expired - Lifetime
- 2005-02-01 ES ES05716609T patent/ES2304692T3/es not_active Expired - Lifetime
- 2005-02-01 WO PCT/EP2005/050415 patent/WO2005075456A1/en not_active Ceased
-
2009
- 2009-01-14 US US12/320,005 patent/US7820669B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005005638D1 (de) | 2008-05-08 |
| DE602005005638T2 (de) | 2009-05-14 |
| WO2005075456A1 (en) | 2005-08-18 |
| US7820669B2 (en) | 2010-10-26 |
| WO2005075456A8 (en) | 2006-03-02 |
| ES2304692T3 (es) | 2008-10-16 |
| EP1716133A1 (en) | 2006-11-02 |
| US7494990B2 (en) | 2009-02-24 |
| ATE390419T1 (de) | 2008-04-15 |
| CA2554797A1 (en) | 2005-08-18 |
| US20070179146A1 (en) | 2007-08-02 |
| AU2005210042A1 (en) | 2005-08-18 |
| US20090131448A1 (en) | 2009-05-21 |
| EP1716133B1 (en) | 2008-03-26 |
| JP4778449B2 (ja) | 2011-09-21 |
| AU2005210042B2 (en) | 2011-04-21 |
| JP2007520528A (ja) | 2007-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170201 |