CA2553345C - Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 - Google Patents

Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 Download PDF

Info

Publication number
CA2553345C
CA2553345C CA2553345A CA2553345A CA2553345C CA 2553345 C CA2553345 C CA 2553345C CA 2553345 A CA2553345 A CA 2553345A CA 2553345 A CA2553345 A CA 2553345A CA 2553345 C CA2553345 C CA 2553345C
Authority
CA
Canada
Prior art keywords
crystalline
anhydrate
monohydrate
solid
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2553345A
Other languages
English (en)
French (fr)
Other versions
CA2553345A1 (en
Inventor
Yuri Bereznitski
Mark A. Huffman
Joseph E. Lynch
Matthew Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of CA2553345A1 publication Critical patent/CA2553345A1/en
Application granted granted Critical
Publication of CA2553345C publication Critical patent/CA2553345C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2553345A 2004-01-26 2005-01-21 Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 Expired - Fee Related CA2553345C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53920604P 2004-01-26 2004-01-26
US60/539,206 2004-01-26
PCT/US2005/001928 WO2005073200A1 (en) 2004-01-26 2005-01-21 Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1

Publications (2)

Publication Number Publication Date
CA2553345A1 CA2553345A1 (en) 2005-08-11
CA2553345C true CA2553345C (en) 2011-11-15

Family

ID=34826043

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2553345A Expired - Fee Related CA2553345C (en) 2004-01-26 2005-01-21 Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1

Country Status (8)

Country Link
US (1) US7875642B2 (cg-RX-API-DMAC7.html)
EP (1) EP1711477A4 (cg-RX-API-DMAC7.html)
JP (1) JP2007519726A (cg-RX-API-DMAC7.html)
CN (1) CN1910161A (cg-RX-API-DMAC7.html)
AU (1) AU2005207925B2 (cg-RX-API-DMAC7.html)
CA (1) CA2553345C (cg-RX-API-DMAC7.html)
IN (1) IN2012DN03023A (cg-RX-API-DMAC7.html)
WO (1) WO2005073200A1 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5140577B2 (ja) 2005-03-31 2013-02-06 タケダ カリフォルニア インコーポレイテッド ヒドロキシステロイドデヒドロゲナーゼ阻害剤
US7579360B2 (en) 2005-06-09 2009-08-25 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
WO2007038452A1 (en) * 2005-09-28 2007-04-05 Merck & Co., Inc. Process for synthesizing 1,2,4-triazoles
WO2007082808A2 (en) 2006-01-18 2007-07-26 F. Hoffmann-La Roche Ag Thiazoles as 11 beta-hsd1 inhibitors
AR059355A1 (es) 2006-02-07 2008-03-26 Wyeth Corp Inhibidores de 11-beta hsd1
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
KR101477154B1 (ko) * 2010-10-01 2014-12-29 산동 루예 파마슈티칼 컴파니 리미티드 4-[2-디메틸아미노-1-(1-하이드록시사이클로헥실)에틸]페닐 4-메틸벤조에이트 하이드로클로라이드의 다형체, 이의 제조 방법 및 이의 용도
CN117398398A (zh) 2017-03-06 2024-01-16 云顶新耀新加坡有限公司 包含β-内酰胺酶抑制剂的固体形式和组合式组合物及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0100860A3 (en) 1997-12-11 2003-03-28 Janssen Pharmaceutica Nv Retinoic acid mimetic anilides, process for their preparation and pharmaceutical compositions containing them
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US20030073850A1 (en) 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
WO2003004497A1 (en) 2001-07-05 2003-01-16 Sumitomo Pharmaceuticals Company, Limited Novel heterocyclic compound
CA2474168A1 (en) * 2002-02-01 2003-08-14 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
AR040241A1 (es) * 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia

Also Published As

Publication number Publication date
US7875642B2 (en) 2011-01-25
EP1711477A4 (en) 2009-06-10
IN2012DN03023A (cg-RX-API-DMAC7.html) 2015-07-31
CA2553345A1 (en) 2005-08-11
CN1910161A (zh) 2007-02-07
JP2007519726A (ja) 2007-07-19
WO2005073200A1 (en) 2005-08-11
AU2005207925A1 (en) 2005-08-11
EP1711477A1 (en) 2006-10-18
US20090186928A1 (en) 2009-07-23
AU2005207925B2 (en) 2008-09-04

Similar Documents

Publication Publication Date Title
JP3145410B2 (ja) 新規な４，６−ジアリールピリミジン誘導体及びその塩
JPWO1996032384A1 (ja) 新規な４，６−ジアリールピリミジン誘導体及びその塩
US20250243223A1 (en) Solid state forms of ixazomib citrate
CA2553345C (en) Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1
CZ33196A3 (en) Derivatives of benzopyran per se, for the use as medicinal preparations and for treating diseases, process and intermediates for their preparation, pharmaceutical compositions based thereon and process of their preparation
HUT64759A (en) Method for producing tetrazolyl-(phenoxy-and phenoxy-alkyl-)-pyridinyl-pyridazines
US11299462B2 (en) Crystal form of oxopicolinamide derivative and preparation method therefor
US6531609B2 (en) Process for the preparation of thiazolidinedione derivatives
EP1858844A1 (en) Novel crystalline forms of antidiabetic compounds
AU2009324810B2 (en) Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1
EP3960742A1 (en) Crystals of alkynyl-containing compound, salt and solvate thereof, preparation method, and applications
US6063799A (en) Alternate crystal form of Tazofelone
EP0761656B1 (en) Alternate crystal form of tazofelone ((+,-)-5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methyl)-4-thiazolidinone)
CN117430571A (zh) 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法
CN121039118A (zh) 含三唑基的化合物
HK40025351B (en) Crystal form of oxopicolinamide derivative and preparation method therefor
HK40025351A (en) Crystal form of oxopicolinamide derivative and preparation method therefor
HU211665A9 (hu) Az átmeneti oltalom az 1-19. igénypontokra vonatkozik.
HK1013822A (en) Alternate crystal form of tazofelone ((+,-)-5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methyl)-4-thiazolidinone)

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150121