CA2549413A1 - Facteur ix glycopegyle - Google Patents
Facteur ix glycopegyle Download PDFInfo
- Publication number
- CA2549413A1 CA2549413A1 CA002549413A CA2549413A CA2549413A1 CA 2549413 A1 CA2549413 A1 CA 2549413A1 CA 002549413 A CA002549413 A CA 002549413A CA 2549413 A CA2549413 A CA 2549413A CA 2549413 A1 CA2549413 A1 CA 2549413A1
- Authority
- CA
- Canada
- Prior art keywords
- factor
- peptide
- moiety
- peg
- member selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52708903P | 2003-12-03 | 2003-12-03 | |
US60/527,089 | 2003-12-03 | ||
US53938704P | 2004-01-26 | 2004-01-26 | |
US60/539,387 | 2004-01-26 | ||
US59274404P | 2004-07-29 | 2004-07-29 | |
US60/592,744 | 2004-07-29 | ||
US61451804P | 2004-09-29 | 2004-09-29 | |
US60/614,518 | 2004-09-29 | ||
US62338704P | 2004-10-29 | 2004-10-29 | |
US60/623,387 | 2004-10-29 | ||
PCT/US2004/041070 WO2005055950A2 (fr) | 2003-12-03 | 2004-12-03 | Facteur ix glycopegyle |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2549413A1 true CA2549413A1 (fr) | 2005-06-23 |
Family
ID=34682416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002549413A Abandoned CA2549413A1 (fr) | 2003-12-03 | 2004-12-03 | Facteur ix glycopegyle |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1694315A4 (fr) |
JP (1) | JP4738346B2 (fr) |
KR (1) | KR101209111B1 (fr) |
AU (1) | AU2004296860B2 (fr) |
BR (1) | BRPI0417341A (fr) |
CA (1) | CA2549413A1 (fr) |
IL (1) | IL175661A0 (fr) |
MX (1) | MXPA06006023A (fr) |
NZ (1) | NZ546733A (fr) |
WO (1) | WO2005055950A2 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
AU2004221824B2 (en) | 2003-03-14 | 2009-08-27 | Ratiopharm Gmbh | Branched water-soluble polymers and their conjugates |
US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
WO2005012484A2 (fr) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Conjugues anticorps-toxines |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
US7338933B2 (en) | 2004-01-08 | 2008-03-04 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
ES2390082T5 (es) | 2004-06-30 | 2018-01-19 | Nektar Therapeutics | Conjugados de resto de Factor IX y polímeros |
AU2014280936B2 (en) * | 2004-06-30 | 2016-12-15 | Nektar Therapeutics | Polymer-factor ix moiety conjugates |
EP1771066A2 (fr) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon glp-1 |
US8268967B2 (en) | 2004-09-10 | 2012-09-18 | Novo Nordisk A/S | Glycopegylated interferon α |
WO2006050247A2 (fr) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodelage et glycopegylation du facteur de croissance des fibroblastes (fgf) |
AU2006203792B2 (en) | 2005-01-10 | 2011-11-03 | Ratiopharm Gmbh | Glycopegylated Granulocyte Colony Stimulating Factor |
EP1871795A4 (fr) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase |
EP1891231A4 (fr) * | 2005-05-25 | 2011-06-22 | Novo Nordisk As | Facteur ix glycopegyle |
EP1937719A4 (fr) * | 2005-08-19 | 2010-11-24 | Novo Nordisk As | Facteur vii et facteur viia glycopégylé |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (fr) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Purification de sucre de nucleotide en utilisant des membranes |
US20080242607A1 (en) | 2006-07-21 | 2008-10-02 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
LT2068907T (lt) * | 2006-10-04 | 2018-01-10 | Novo Nordisk A/S | Glicerolio sujungti pegilinti sacharidai ir glikopeptidai |
CN105838699A (zh) | 2006-12-15 | 2016-08-10 | 巴克斯艾尔塔公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
KR20100016160A (ko) | 2007-04-03 | 2010-02-12 | 바이오제너릭스 에이지 | 글리코페길화 g―csf를 이용하는 치료 방법 |
EP2517714A1 (fr) * | 2007-04-26 | 2012-10-31 | Inspiration Biopharmaceuticals, Inc. | Protéines dépendantes de la vitamine K recombinées à teneur élevée en acide sialique et leurs procédés de préparation |
MX2009013259A (es) | 2007-06-12 | 2010-01-25 | Novo Nordisk As | Proceso mejorado para la produccion de azucares de nucleotidos. |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
WO2009051717A2 (fr) * | 2007-10-15 | 2009-04-23 | The University Of North Carolina At Chapel Hill | Variantes du facteur ix humain qui présentent une demi-vie prolongée |
WO2009083187A1 (fr) * | 2007-12-27 | 2009-07-09 | Baxter International Inc. | Facteur ix chimiquement modifié |
EP2626080A3 (fr) | 2008-02-27 | 2014-03-05 | Novo Nordisk A/S | Molécules de facteur VIII conjuguées |
WO2009137254A2 (fr) * | 2008-04-16 | 2009-11-12 | Bayer Healthcare Llc | Polypeptides modifiés de facteur ix et leurs utilisations |
KR102068133B1 (ko) | 2009-07-27 | 2020-01-20 | 박스알타 인코퍼레이티드 | 혈액 응고 단백질 복합체 |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
JP5909755B2 (ja) | 2009-07-27 | 2016-04-27 | リポクセン テクノロジーズ リミテッド | 非血液凝固タンパク質の糖ポリシアル酸化 |
CN106110311A (zh) | 2009-07-27 | 2016-11-16 | 百深公司 | 凝血蛋白缀合物 |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
PE20121643A1 (es) * | 2009-07-31 | 2012-11-25 | Bayer Healthcare Llc | Polipeptidos del factor ix modificados y usos de los mismos |
CN102639553A (zh) | 2009-11-24 | 2012-08-15 | 诺沃—诺迪斯克保健股份有限公司 | 纯化聚乙二醇化蛋白质的方法 |
AU2011274414B2 (en) | 2010-07-09 | 2016-10-06 | Bioverativ Therapeutics Inc. | Factor IX polypeptides and methods of use thereof |
JP6138052B2 (ja) | 2010-12-22 | 2017-05-31 | バクスアルタ ゲーエムベーハー | 水溶性脂肪酸誘導体をタンパク質に抱合させるための材料および方法 |
TW201519900A (zh) * | 2013-04-28 | 2015-06-01 | Bayer Healthcare Llc | 用於誘導對凝血因子蛋白之免疫耐受性的組成物及方法 |
US20220154161A1 (en) | 2019-03-19 | 2022-05-19 | CSL Behring Lengnau AG | Factor ix variants and uses thereof in therapy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59172425A (ja) * | 1983-03-18 | 1984-09-29 | Nippon Chemiphar Co Ltd | 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
MXPA00005376A (es) * | 1997-12-01 | 2002-07-02 | Neose Technologies Inc | Sintesis enzimatica de gangliosidos. |
AU2002360264B2 (en) * | 2001-10-10 | 2009-03-19 | Novo Nordisk A/S | Remodeling and glycoconjugation of peptides |
-
2004
- 2004-12-03 BR BRPI0417341-4A patent/BRPI0417341A/pt not_active Application Discontinuation
- 2004-12-03 CA CA002549413A patent/CA2549413A1/fr not_active Abandoned
- 2004-12-03 NZ NZ546733A patent/NZ546733A/en not_active IP Right Cessation
- 2004-12-03 WO PCT/US2004/041070 patent/WO2005055950A2/fr active Application Filing
- 2004-12-03 EP EP04813394A patent/EP1694315A4/fr not_active Withdrawn
- 2004-12-03 MX MXPA06006023A patent/MXPA06006023A/es active IP Right Grant
- 2004-12-03 JP JP2006542888A patent/JP4738346B2/ja not_active Expired - Fee Related
- 2004-12-03 AU AU2004296860A patent/AU2004296860B2/en not_active Ceased
-
2006
- 2006-05-16 IL IL175661A patent/IL175661A0/en unknown
- 2006-05-30 KR KR1020067010603A patent/KR101209111B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BRPI0417341A (pt) | 2007-04-17 |
WO2005055950A2 (fr) | 2005-06-23 |
IL175661A0 (en) | 2006-09-05 |
JP4738346B2 (ja) | 2011-08-03 |
NZ546733A (en) | 2009-07-31 |
KR20060123224A (ko) | 2006-12-01 |
MXPA06006023A (es) | 2006-08-23 |
EP1694315A2 (fr) | 2006-08-30 |
AU2004296860A1 (en) | 2005-06-23 |
EP1694315A4 (fr) | 2009-10-28 |
JP2007513190A (ja) | 2007-05-24 |
AU2004296860B2 (en) | 2010-04-22 |
WO2005055950A3 (fr) | 2005-10-20 |
KR101209111B1 (ko) | 2012-12-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2004296860B2 (en) | Glycopegylated factor IX | |
AU2004296855B2 (en) | Glycopegylated Granulocyte Colony Stimulating Factor | |
CA2682897C (fr) | Methodes de traitement a l'aide d'un facteur g-csf glycopegyle | |
CA2593682C (fr) | Facteur de stimulation de colonie de granulocytes glycopegylatees | |
US20080318850A1 (en) | Glycopegylated Factor Ix | |
WO2005056760A2 (fr) | Hormone stimulant le follicule humain glycopegyle | |
ZA200604554B (en) | Glycopegylated Factor IX | |
RU2400490C2 (ru) | Гликопэгилированный гранулоцитарный колониестимулирующий фактор |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |
Effective date: 20170213 |