CA2540543A1 - Tetrahydropyridine derivatives - Google Patents
Tetrahydropyridine derivatives Download PDFInfo
- Publication number
- CA2540543A1 CA2540543A1 CA002540543A CA2540543A CA2540543A1 CA 2540543 A1 CA2540543 A1 CA 2540543A1 CA 002540543 A CA002540543 A CA 002540543A CA 2540543 A CA2540543 A CA 2540543A CA 2540543 A1 CA2540543 A1 CA 2540543A1
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- heteroaryl
- mmol
- chloro
- renal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP03/11146 | 2003-10-09 | ||
| EP0311146 | 2003-10-09 | ||
| PCT/EP2004/011088 WO2005040120A1 (en) | 2003-10-09 | 2004-10-05 | Tetrahydropyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2540543A1 true CA2540543A1 (en) | 2005-05-06 |
Family
ID=34486009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002540543A Abandoned CA2540543A1 (en) | 2003-10-09 | 2004-10-05 | Tetrahydropyridine derivatives |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080234305A1 (https=) |
| JP (1) | JP2007508260A (https=) |
| CN (1) | CN1863773A (https=) |
| AU (1) | AU2004283814A1 (https=) |
| CA (1) | CA2540543A1 (https=) |
| WO (1) | WO2005040120A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE462703T1 (de) * | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
| GB0500784D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| JP2009502751A (ja) * | 2005-07-22 | 2009-01-29 | メルク フロスト カナダ リミテツド | レニン阻害薬 |
| BRPI0620736A2 (pt) | 2005-12-30 | 2011-12-20 | Novartis Ag | compostos orgánicos |
| EP2029542A2 (en) * | 2006-03-03 | 2009-03-04 | Actelion Pharmaceuticals Ltd. | Primary amines as renin inhibitors |
| CN101395149A (zh) * | 2006-03-08 | 2009-03-25 | 埃科特莱茵药品有限公司 | 新颖胺类 |
| EP1908471A1 (en) * | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
| AU2008253519A1 (en) | 2007-05-24 | 2008-11-27 | Merck Frosst Canada Ltd | Novel case of renin inhibitors |
| SG182223A1 (en) | 2007-06-25 | 2012-07-30 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
| AU2008288648A1 (en) | 2007-08-20 | 2009-02-26 | Merck Frosst Canada Ltd. | Renin inhibitors |
| CN101888999B (zh) * | 2007-12-05 | 2013-12-11 | 巴斯夫欧洲公司 | 吡啶基甲基磺酰胺化合物 |
| JP5328816B2 (ja) | 2008-02-22 | 2013-10-30 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβの調節薬 |
| KR101403311B1 (ko) | 2008-05-05 | 2014-06-05 | 액테리온 파마슈티칼 리미티드 | 레닌 억제제로서의 3,4-치환된 피페리딘 유도체 |
| WO2010040661A1 (en) | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| AU2009312856A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| JP5781943B2 (ja) | 2009-01-21 | 2015-09-24 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体 |
| CN101696187B (zh) * | 2009-09-30 | 2011-09-07 | 徐州工业职业技术学院 | N-取代基-1,2,3,6-四氢吡啶的合成方法 |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| KR101905927B1 (ko) | 2010-11-17 | 2018-10-08 | 이도르시아 파마슈티컬스 리미티드 | 가교된 스피로［２．４］헵탄 에스테르 유도체 |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| RU2002126554A (ru) * | 2000-03-06 | 2004-03-20 | Акадиа Фармасьютикалз, Инк. (Us) | Азациклические соединения для применения при лечении опосредованных серотонином заболеваний |
| US20030013883A1 (en) * | 2000-06-16 | 2003-01-16 | Tamagnan Gilles D. | Tropane analogs binding to monoamine transporters |
| CA2483241C (en) * | 2002-04-29 | 2011-05-31 | Actelion Pharmaceuticals Ltd | Novel diazabicyclononene derivatives |
| RU2005102002A (ru) * | 2002-06-27 | 2005-09-20 | Актелион Фармасьютиклз Лтд. (Ch) | Новые производные тетрагидропиридина |
-
2004
- 2004-10-05 CA CA002540543A patent/CA2540543A1/en not_active Abandoned
- 2004-10-05 AU AU2004283814A patent/AU2004283814A1/en not_active Abandoned
- 2004-10-05 JP JP2006530088A patent/JP2007508260A/ja active Pending
- 2004-10-05 CN CNA2004800293878A patent/CN1863773A/zh active Pending
- 2004-10-05 WO PCT/EP2004/011088 patent/WO2005040120A1/en not_active Ceased
- 2004-10-05 US US10/575,348 patent/US20080234305A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007508260A (ja) | 2007-04-05 |
| CN1863773A (zh) | 2006-11-15 |
| WO2005040120A1 (en) | 2005-05-06 |
| US20080234305A1 (en) | 2008-09-25 |
| AU2004283814A1 (en) | 2005-05-06 |
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