CA2540076A1 - Dispositif ophtalmique comprenant un capteur holographique - Google Patents
Dispositif ophtalmique comprenant un capteur holographique Download PDFInfo
- Publication number
- CA2540076A1 CA2540076A1 CA002540076A CA2540076A CA2540076A1 CA 2540076 A1 CA2540076 A1 CA 2540076A1 CA 002540076 A CA002540076 A CA 002540076A CA 2540076 A CA2540076 A CA 2540076A CA 2540076 A1 CA2540076 A1 CA 2540076A1
- Authority
- CA
- Canada
- Prior art keywords
- medium
- glucose
- holographic
- acid
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 56
- 239000008103 glucose Substances 0.000 claims abstract description 56
- 239000012491 analyte Substances 0.000 claims abstract description 21
- 230000003287 optical effect Effects 0.000 claims abstract description 15
- 230000003993 interaction Effects 0.000 claims abstract description 12
- 239000012530 fluid Substances 0.000 claims abstract description 11
- 230000000704 physical effect Effects 0.000 claims abstract description 10
- 238000001514 detection method Methods 0.000 claims abstract description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 18
- 230000008859 change Effects 0.000 claims description 14
- 239000000178 monomer Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical group OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 claims description 8
- 125000005620 boronic acid group Chemical group 0.000 claims description 7
- 238000004132 cross linking Methods 0.000 claims description 7
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 6
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 6
- 229910052796 boron Inorganic materials 0.000 claims description 6
- 230000002441 reversible effect Effects 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- NEYTXADIGVEHQD-UHFFFAOYSA-N 2-hydroxy-2-(prop-2-enoylamino)acetic acid Chemical compound OC(=O)C(O)NC(=O)C=C NEYTXADIGVEHQD-UHFFFAOYSA-N 0.000 claims description 4
- ULVXDHIJOKEBMW-UHFFFAOYSA-N [3-(prop-2-enoylamino)phenyl]boronic acid Chemical compound OB(O)C1=CC=CC(NC(=O)C=C)=C1 ULVXDHIJOKEBMW-UHFFFAOYSA-N 0.000 claims description 4
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 4
- VNVCFMWOHSTLRQ-UHFFFAOYSA-N [5-fluoro-2-(2-methylprop-2-enoylamino)phenyl]boronic acid Chemical compound CC(=C)C(=O)NC1=CC=C(F)C=C1B(O)O VNVCFMWOHSTLRQ-UHFFFAOYSA-N 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 3
- 229910052709 silver Inorganic materials 0.000 claims description 3
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
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- KUQRLZZWFINMDP-BGNLRFAXSA-N 2-[(3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O KUQRLZZWFINMDP-BGNLRFAXSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108010062580 Concanavalin A Proteins 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000036765 blood level Effects 0.000 description 3
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 3
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- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
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- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 229920002396 Polyurea Polymers 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
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- 238000002835 absorbance Methods 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
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- 239000008273 gelatin Substances 0.000 description 2
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- KVZLHPXEUGJPAH-UHFFFAOYSA-N 2-oxidanylpropanoic acid Chemical compound CC(O)C(O)=O.CC(O)C(O)=O KVZLHPXEUGJPAH-UHFFFAOYSA-N 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
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- 239000004971 Cross linker Substances 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
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- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
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- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
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- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
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- 235000012209 glucono delta-lactone Nutrition 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 108010070004 glucose receptor Proteins 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
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- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 1
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- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- ADTJPOBHAXXXFS-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]prop-2-enamide Chemical compound CN(C)CCCNC(=O)C=C ADTJPOBHAXXXFS-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920000083 poly(allylamine) Polymers 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N2021/758—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated using reversible reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N2021/7706—Reagent provision
- G01N2021/7723—Swelling part, also for adsorption sensor, i.e. without chemical reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7773—Reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Prostheses (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0322488A GB0322488D0 (en) | 2003-09-25 | 2003-09-25 | Ophthalmic device |
| GB0322488.8 | 2003-09-25 | ||
| GB0401399.1 | 2004-01-22 | ||
| GB0401399A GB0401399D0 (en) | 2004-01-22 | 2004-01-22 | Ophthalmic device |
| PCT/GB2004/004093 WO2005031442A1 (fr) | 2003-09-25 | 2004-09-27 | Dispositif ophtalmique comprenant un capteur holographique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2540076A1 true CA2540076A1 (fr) | 2005-04-07 |
Family
ID=34395443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002540076A Abandoned CA2540076A1 (fr) | 2003-09-25 | 2004-09-27 | Dispositif ophtalmique comprenant un capteur holographique |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1664909A1 (fr) |
| JP (1) | JP4566996B2 (fr) |
| AU (1) | AU2004276949B2 (fr) |
| CA (1) | CA2540076A1 (fr) |
| WO (1) | WO2005031442A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0412654D0 (en) * | 2004-06-07 | 2004-07-07 | Univ Cambridge Tech | Method of detection |
| US9248614B2 (en) | 2004-06-30 | 2016-02-02 | Novartis Ag | Method for lathing silicone hydrogel lenses |
| GB0419827D0 (en) | 2004-09-07 | 2004-10-13 | Univ Cambridge Tech | Sensor |
| GB0514699D0 (en) * | 2005-07-18 | 2005-08-24 | Smart Holograms Ltd | Holographic sensors and their use |
| US7671156B2 (en) | 2005-08-10 | 2010-03-02 | Novartis Ag | Silicone hydrogels |
| GB0520116D0 (en) * | 2005-10-03 | 2005-11-09 | Smart Holograms Ltd | Use of holographic sensors |
| GB0522796D0 (en) * | 2005-11-08 | 2005-12-14 | Smart Holograms Ltd | Novel boronate complex and its use in a glucose sensor |
| WO2007054689A1 (fr) * | 2005-11-08 | 2007-05-18 | Smart Holograms Limited | Nouveau complexe de boronate et son utilisation dans une sonde à glucose |
| EP1969397B1 (fr) | 2005-12-14 | 2017-11-08 | Novartis AG | Méthode de préparation d'hydrogels de silicone |
| GB0617730D0 (en) * | 2006-09-08 | 2006-10-18 | Smart Holograms Ltd | Analyte detection |
| US20080151181A1 (en) * | 2006-12-20 | 2008-06-26 | Bausch & Lomb Incorporated | Coatings and Solutions for Contact Lenses |
| WO2010077646A2 (fr) * | 2008-12-30 | 2010-07-08 | Bausch & Lomb Incorporated | Procédé d'application d'un revêtement polymère renouvelable de lentille |
| WO2010077709A2 (fr) * | 2008-12-30 | 2010-07-08 | Bausch & Lomb Incorporated | Dispositifs biomédicaux |
| US8454689B2 (en) * | 2008-12-30 | 2013-06-04 | Bausch & Lomb Incorporated | Brush copolymers |
| US20120177576A1 (en) * | 2009-09-18 | 2012-07-12 | Jun Jack Hu | Optical device and method for non-invasive real-time testing of blood sugar levels |
| US8410190B2 (en) * | 2009-09-22 | 2013-04-02 | Coopervision International Holding Company, Lp | Wettable hydrogel materials for use in ophthalmic applications and methods |
| JP5622188B2 (ja) * | 2010-01-05 | 2014-11-12 | 独立行政法人物質・材料研究機構 | フェニルボロン酸系単量体及びフェニルボロン酸系重合体 |
| JP6194127B2 (ja) * | 2015-08-10 | 2017-09-06 | 株式会社メニコン | グルコース検出体及びグルコース検出方法 |
| WO2019031114A1 (fr) * | 2017-08-10 | 2019-02-14 | Jsr株式会社 | Polymère, composition de résine, film de résine, procédé de production de film de résine à motifs, et composant électronique |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9406142D0 (en) * | 1994-03-28 | 1994-05-18 | British Tech Group | A sensor |
| US7105352B2 (en) * | 1996-11-06 | 2006-09-12 | University Of Pittsburgh | Intelligent polymerized crystalline colloidal array carbohydrate sensors |
| AU750402B2 (en) * | 1997-12-29 | 2002-07-18 | Novartis Ag | Composite holographic multifocal lens |
| US6139146A (en) * | 1997-12-29 | 2000-10-31 | Novartis Ag | Programmable corrective lenses |
| US6579673B2 (en) * | 1998-12-17 | 2003-06-17 | Kimberly-Clark Worldwide, Inc. | Patterned deposition of antibody binding protein for optical diffraction-based biosensors |
| HU226183B1 (en) * | 1999-08-26 | 2008-06-30 | Novartis Ag | Ophthalmic lens and sensor system for measuring the concentration of an analyte in an ocular fluid |
| US6366793B1 (en) * | 1999-09-10 | 2002-04-02 | Beckman Coulter, Inc. | Minimally invasive methods for measuring analtes in vivo |
| GB0000209D0 (en) * | 2000-01-07 | 2000-03-01 | Holmetrica Limited | Holographic multiplexed image sensor |
-
2004
- 2004-09-27 JP JP2006527481A patent/JP4566996B2/ja not_active Expired - Fee Related
- 2004-09-27 EP EP04768637A patent/EP1664909A1/fr not_active Withdrawn
- 2004-09-27 CA CA002540076A patent/CA2540076A1/fr not_active Abandoned
- 2004-09-27 WO PCT/GB2004/004093 patent/WO2005031442A1/fr active Application Filing
- 2004-09-27 AU AU2004276949A patent/AU2004276949B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4566996B2 (ja) | 2010-10-20 |
| AU2004276949A1 (en) | 2005-04-07 |
| AU2004276949B2 (en) | 2008-07-31 |
| JP2007506999A (ja) | 2007-03-22 |
| EP1664909A1 (fr) | 2006-06-07 |
| WO2005031442A1 (fr) | 2005-04-07 |
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| EEER | Examination request | ||
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