CA2538245A1 - Oligonucleotides ciblant les maladies a prions - Google Patents
Oligonucleotides ciblant les maladies a prions Download PDFInfo
- Publication number
- CA2538245A1 CA2538245A1 CA002538245A CA2538245A CA2538245A1 CA 2538245 A1 CA2538245 A1 CA 2538245A1 CA 002538245 A CA002538245 A CA 002538245A CA 2538245 A CA2538245 A CA 2538245A CA 2538245 A1 CA2538245 A1 CA 2538245A1
- Authority
- CA
- Canada
- Prior art keywords
- oligonucleotide
- prion
- oligonucleotides
- nucleotides
- length
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 208000024777 Prion disease Diseases 0.000 title claims abstract description 49
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- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229940124024 weight reducing agent Drugs 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2003/004573 WO2004024919A1 (fr) | 2002-09-13 | 2003-09-11 | Oligonucleotides antiviraux non complementaires de sequence |
IBPCT/IB03/04573 | 2003-09-11 | ||
US58462704P | 2004-06-06 | 2004-06-06 | |
US60/584,627 | 2004-06-06 | ||
PCT/IB2004/003740 WO2005025487A2 (fr) | 2003-09-11 | 2004-09-10 | Oligonucleotides ciblant les maladies a prions |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2538245A1 true CA2538245A1 (fr) | 2005-03-24 |
Family
ID=34315467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002538245A Abandoned CA2538245A1 (fr) | 2003-09-11 | 2004-09-10 | Oligonucleotides ciblant les maladies a prions |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1667695A4 (fr) |
AU (1) | AU2004271807A1 (fr) |
CA (1) | CA2538245A1 (fr) |
WO (1) | WO2005025487A2 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006119643A1 (fr) * | 2005-05-12 | 2006-11-16 | Replicor Inc. | Molecules contre l'angiogenese oculaire et leurs utilisations |
WO2006122409A1 (fr) * | 2005-05-16 | 2006-11-23 | Replicor Inc. | Molecules antimicrobiennnes et leur utilisation |
WO2006130949A1 (fr) * | 2005-06-08 | 2006-12-14 | Replicor Inc. | Molecules contre des maladies liees a l'amyloide et leur utilisation |
US20090215873A1 (en) * | 2005-09-29 | 2009-08-27 | Andrew Vaillant | Therapeutic Molecules and their Uses |
AU2006302022A1 (en) * | 2005-10-06 | 2007-04-19 | University Of Delaware | G-rich polynucleotides for the treatment of Huntington's Disease |
US11166976B2 (en) | 2018-11-08 | 2021-11-09 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997015685A1 (fr) * | 1995-10-26 | 1997-05-01 | Winnacker Ernst Ludwig | MOLECULES D'ACIDE NUCLEIQUE CAPABLES DE DISTINGUER LES ISOFORMES PrP?C ET PrPSc¿ DE PROTEINES A PRIONS ET PROCEDES DE PRODUCTION DE CES MOLECULES |
GB0012054D0 (en) * | 2000-05-18 | 2000-07-12 | Isis Innovation | Ligands |
EP1333090A1 (fr) * | 2002-02-01 | 2003-08-06 | NascaCell GmbH | Aptameres specifiques pour proteines de prion |
BR0314236A (pt) * | 2002-09-13 | 2005-08-09 | Replicor Inc | Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos |
-
2004
- 2004-09-10 EP EP04787566A patent/EP1667695A4/fr not_active Withdrawn
- 2004-09-10 CA CA002538245A patent/CA2538245A1/fr not_active Abandoned
- 2004-09-10 WO PCT/IB2004/003740 patent/WO2005025487A2/fr active Application Filing
- 2004-09-10 AU AU2004271807A patent/AU2004271807A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1667695A4 (fr) | 2007-01-31 |
WO2005025487A3 (fr) | 2005-12-01 |
WO2005025487A2 (fr) | 2005-03-24 |
WO2005025487A9 (fr) | 2006-06-22 |
EP1667695A2 (fr) | 2006-06-14 |
AU2004271807A1 (en) | 2005-03-24 |
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