CA2538245A1 - Oligonucleotides ciblant les maladies a prions - Google Patents

Oligonucleotides ciblant les maladies a prions Download PDF

Info

Publication number
CA2538245A1
CA2538245A1 CA002538245A CA2538245A CA2538245A1 CA 2538245 A1 CA2538245 A1 CA 2538245A1 CA 002538245 A CA002538245 A CA 002538245A CA 2538245 A CA2538245 A CA 2538245A CA 2538245 A1 CA2538245 A1 CA 2538245A1
Authority
CA
Canada
Prior art keywords
oligonucleotide
prion
oligonucleotides
nucleotides
length
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002538245A
Other languages
English (en)
Inventor
Jean-Marc Juteau
Andrew Vaillant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Replicor Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2003/004573 external-priority patent/WO2004024919A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2538245A1 publication Critical patent/CA2538245A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002538245A 2003-09-11 2004-09-10 Oligonucleotides ciblant les maladies a prions Abandoned CA2538245A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/IB2003/004573 WO2004024919A1 (fr) 2002-09-13 2003-09-11 Oligonucleotides antiviraux non complementaires de sequence
IBPCT/IB03/04573 2003-09-11
US58462704P 2004-06-06 2004-06-06
US60/584,627 2004-06-06
PCT/IB2004/003740 WO2005025487A2 (fr) 2003-09-11 2004-09-10 Oligonucleotides ciblant les maladies a prions

Publications (1)

Publication Number Publication Date
CA2538245A1 true CA2538245A1 (fr) 2005-03-24

Family

ID=34315467

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002538245A Abandoned CA2538245A1 (fr) 2003-09-11 2004-09-10 Oligonucleotides ciblant les maladies a prions

Country Status (4)

Country Link
EP (1) EP1667695A4 (fr)
AU (1) AU2004271807A1 (fr)
CA (1) CA2538245A1 (fr)
WO (1) WO2005025487A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006119643A1 (fr) * 2005-05-12 2006-11-16 Replicor Inc. Molecules contre l'angiogenese oculaire et leurs utilisations
WO2006122409A1 (fr) * 2005-05-16 2006-11-23 Replicor Inc. Molecules antimicrobiennnes et leur utilisation
WO2006130949A1 (fr) * 2005-06-08 2006-12-14 Replicor Inc. Molecules contre des maladies liees a l'amyloide et leur utilisation
US20090215873A1 (en) * 2005-09-29 2009-08-27 Andrew Vaillant Therapeutic Molecules and their Uses
AU2006302022A1 (en) * 2005-10-06 2007-04-19 University Of Delaware G-rich polynucleotides for the treatment of Huntington's Disease
US11166976B2 (en) 2018-11-08 2021-11-09 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015685A1 (fr) * 1995-10-26 1997-05-01 Winnacker Ernst Ludwig MOLECULES D'ACIDE NUCLEIQUE CAPABLES DE DISTINGUER LES ISOFORMES PrP?C ET PrPSc¿ DE PROTEINES A PRIONS ET PROCEDES DE PRODUCTION DE CES MOLECULES
GB0012054D0 (en) * 2000-05-18 2000-07-12 Isis Innovation Ligands
EP1333090A1 (fr) * 2002-02-01 2003-08-06 NascaCell GmbH Aptameres specifiques pour proteines de prion
BR0314236A (pt) * 2002-09-13 2005-08-09 Replicor Inc Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos

Also Published As

Publication number Publication date
EP1667695A4 (fr) 2007-01-31
WO2005025487A3 (fr) 2005-12-01
WO2005025487A2 (fr) 2005-03-24
WO2005025487A9 (fr) 2006-06-22
EP1667695A2 (fr) 2006-06-14
AU2004271807A1 (en) 2005-03-24

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Legal Events

Date Code Title Description
FZDE Dead