CA2532110A1 - Procede de purification de solvants non ioniques pour preparations pharmaceutiques injectables stabilisees - Google Patents

Procede de purification de solvants non ioniques pour preparations pharmaceutiques injectables stabilisees Download PDF

Info

Publication number
CA2532110A1
CA2532110A1 CA002532110A CA2532110A CA2532110A1 CA 2532110 A1 CA2532110 A1 CA 2532110A1 CA 002532110 A CA002532110 A CA 002532110A CA 2532110 A CA2532110 A CA 2532110A CA 2532110 A1 CA2532110 A1 CA 2532110A1
Authority
CA
Canada
Prior art keywords
paclitaxel
solvent
castor oil
process according
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002532110A
Other languages
English (en)
Inventor
Anand C. Burman
Rama Mukherjee
Dinesh Kumar
Dhiraj Khattar
Praveen Khullar
Perundurai S. Srinivasan
Rajesh Srivastava
Mukesh Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Kabi Oncology Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2532110A1 publication Critical patent/CA2532110A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une composition pharmaceutique stabilisée contenant un médicament anticancéreux et une huile de ricin polyéthoxylée (crémophore) de type solvant contenant également un solubilisant de type alcool déshydraté pouvant être administré à un humain. Les compositions préparées à base de cette huile de ricin polyéthoxylée purifiée améliorent la stabilité du paclitaxel contenu dans ces compositions.
CA002532110A 2003-07-24 2003-07-24 Procede de purification de solvants non ioniques pour preparations pharmaceutiques injectables stabilisees Abandoned CA2532110A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/023243 WO2005017079A1 (fr) 2003-07-24 2003-07-24 Procede de purification de solvants non ioniques pour preparations pharmaceutiques injectables stabilisees

Publications (1)

Publication Number Publication Date
CA2532110A1 true CA2532110A1 (fr) 2005-02-24

Family

ID=34192512

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002532110A Abandoned CA2532110A1 (fr) 2003-07-24 2003-07-24 Procede de purification de solvants non ioniques pour preparations pharmaceutiques injectables stabilisees

Country Status (4)

Country Link
EP (1) EP1648988A1 (fr)
AU (1) AU2003256786B2 (fr)
CA (1) CA2532110A1 (fr)
WO (1) WO2005017079A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090022727A1 (en) 2007-01-26 2009-01-22 Alza Corp. Injectable, nonaqueous suspension with high concentration of therapeutic agent
CN112778513A (zh) * 2020-12-30 2021-05-11 江苏优仿医药科技有限公司 一种聚氧乙烯蓖麻油的精制方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
BE1011216A3 (fr) * 1997-06-13 1999-06-01 Thissen En Abrege L T B Lab Forme pharmaceutique pour l'administration de paclitaxel, procede de preparation d'une composition de paclitaxel prete a l'emploi et utilisation de cette composition.
CA2347097C (fr) * 1998-10-20 2009-06-16 Ben Venue Laboratories, Inc. Procede de purification de solvants s'utilisant pour la preparation de compositions pharmaceutiques
EP1251845A1 (fr) * 2000-01-20 2002-10-30 Baker Norton Pharmaceuticals, Inc. Purification d'huile de castor polyoxyethylees avec du charbon active et formulations pharmaceutiques correspondantes

Also Published As

Publication number Publication date
EP1648988A1 (fr) 2006-04-26
AU2003256786A1 (en) 2005-03-07
WO2005017079A1 (fr) 2005-02-24
AU2003256786B2 (en) 2010-01-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued