CA2521274A1 - Combinations comprising anti-epileptic drugs for the treatment of neurological disorders - Google Patents
Combinations comprising anti-epileptic drugs for the treatment of neurological disorders Download PDFInfo
- Publication number
- CA2521274A1 CA2521274A1 CA002521274A CA2521274A CA2521274A1 CA 2521274 A1 CA2521274 A1 CA 2521274A1 CA 002521274 A CA002521274 A CA 002521274A CA 2521274 A CA2521274 A CA 2521274A CA 2521274 A1 CA2521274 A1 CA 2521274A1
- Authority
- CA
- Canada
- Prior art keywords
- combination according
- epilepsy
- administered
- combination
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000001961 anticonvulsive agent Substances 0.000 title claims abstract description 19
- 208000012902 Nervous system disease Diseases 0.000 title abstract description 4
- 208000025966 Neurological disease Diseases 0.000 title abstract description 4
- 206010015037 epilepsy Diseases 0.000 claims abstract description 21
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 230000003556 anti-epileptic effect Effects 0.000 claims abstract description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
- 229960003965 antiepileptics Drugs 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims description 14
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 claims description 13
- 239000005557 antagonist Substances 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 13
- 241001465754 Metazoa Species 0.000 claims description 9
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical group C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims description 9
- 229960000623 carbamazepine Drugs 0.000 claims description 9
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229960001816 oxcarbazepine Drugs 0.000 claims description 6
- CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 claims description 6
- 238000009097 single-agent therapy Methods 0.000 claims description 6
- 229940053193 barbiturates and derivative Drugs 0.000 claims description 5
- 229940049706 benzodiazepine Drugs 0.000 claims description 5
- 150000001557 benzodiazepines Chemical class 0.000 claims description 5
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 5
- 239000000194 fatty acid Substances 0.000 claims description 5
- 229930195729 fatty acid Natural products 0.000 claims description 5
- 150000004665 fatty acids Chemical class 0.000 claims description 5
- 150000001469 hydantoins Chemical class 0.000 claims description 5
- BMPDWHIDQYTSHX-UHFFFAOYSA-N licarbazepine Chemical compound C1C(O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-UHFFFAOYSA-N 0.000 claims description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims description 5
- 229960000604 valproic acid Drugs 0.000 claims description 5
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims description 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims description 2
- 125000001118 alkylidene group Chemical group 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 239000000460 chlorine Chemical group 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 239000011737 fluorine Chemical group 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 description 36
- 230000037396 body weight Effects 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 description 8
- 206010010904 Convulsion Diseases 0.000 description 7
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 6
- 150000003857 carboxamides Chemical class 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 5
- QZULPCPLWGCGSL-UHFFFAOYSA-N irampanel Chemical compound CN(C)CCOC1=CC=CC=C1C1=NC(C=2C=CC=CC=2)=NO1 QZULPCPLWGCGSL-UHFFFAOYSA-N 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- KOZCGZMZXXVHCF-GGMCWBHBSA-N (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrate hydrochloride Chemical compound O.Cl.C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C KOZCGZMZXXVHCF-GGMCWBHBSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- JACAAXNEHGBPOQ-LLVKDONJSA-N Talampanel Chemical compound C([C@H](N(N=1)C(C)=O)C)C2=CC=3OCOC=3C=C2C=1C1=CC=C(N)C=C1 JACAAXNEHGBPOQ-LLVKDONJSA-N 0.000 description 4
- 229940125904 compound 1 Drugs 0.000 description 4
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 4
- 229960003529 diazepam Drugs 0.000 description 4
- 229960001848 lamotrigine Drugs 0.000 description 4
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 description 4
- 229960004002 levetiracetam Drugs 0.000 description 4
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 description 4
- 229960002695 phenobarbital Drugs 0.000 description 4
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 4
- 229960004394 topiramate Drugs 0.000 description 4
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 3
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 3
- HMHVCUVYZFYAJI-UHFFFAOYSA-N Sultiame Chemical compound C1=CC(S(=O)(=O)N)=CC=C1N1S(=O)(=O)CCCC1 HMHVCUVYZFYAJI-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 3
- 229960003120 clonazepam Drugs 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 229960002767 ethosuximide Drugs 0.000 description 3
- HAPOVYFOVVWLRS-UHFFFAOYSA-N ethosuximide Chemical compound CCC1(C)CC(=O)NC1=O HAPOVYFOVVWLRS-UHFFFAOYSA-N 0.000 description 3
- 229960003472 felbamate Drugs 0.000 description 3
- WKGXYQFOCVYPAC-UHFFFAOYSA-N felbamate Chemical compound NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 WKGXYQFOCVYPAC-UHFFFAOYSA-N 0.000 description 3
- 229960002870 gabapentin Drugs 0.000 description 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 3
- 229960004391 lorazepam Drugs 0.000 description 3
- 229960002036 phenytoin Drugs 0.000 description 3
- DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 description 3
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical class [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 3
- IEWVBTBLBYYUTR-UHFFFAOYSA-M sodium;2-[[5-[4-(dimethylsulfamoyl)phenyl]-8-methyl-2-oxo-7,9-dihydro-6h-pyrrolo[3,2-h]isoquinolin-3-yl]amino]oxy-4-hydroxybutanoate Chemical compound [Na+].C1=CC(S(=O)(=O)N(C)C)=CC=C1C1=CC2=C(NOC(CCO)C([O-])=O)C(=O)N=C2C2=C1CCN(C)C2 IEWVBTBLBYYUTR-UHFFFAOYSA-M 0.000 description 3
- 229960002573 sultiame Drugs 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical class C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 description 2
- FPXVCCSOTAQPIV-UHFFFAOYSA-N 4-(8-chloro-2-methyl-11h-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline Chemical compound C12=CC(Cl)=CC=C2CC2=NC(C)=CN2N=C1C1=CC=C(N)C=C1 FPXVCCSOTAQPIV-UHFFFAOYSA-N 0.000 description 2
- -1 7-[4-[[[[(4-carboxyphenyl)amino]carbonyl]oxy]methyl]-1 H-imidazol-1-yl]-3,4-dihydro-3-oxo-(trifluoromethyl)-2-quinoxalinecarboxylic acid Chemical compound 0.000 description 2
- CBHCOCUJJQDHSR-UHFFFAOYSA-N 7-acetyl-5-(4-aminophenyl)-8-methyl-9h-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-8-carbonitrile Chemical compound C12=CC=3OCOC=3C=C2CC(C#N)(C)N(C(=O)C)N=C1C1=CC=C(N)C=C1 CBHCOCUJJQDHSR-UHFFFAOYSA-N 0.000 description 2
- AJXPJJZHWIXJCJ-UHFFFAOYSA-N Methsuximide Chemical compound O=C1N(C)C(=O)CC1(C)C1=CC=CC=C1 AJXPJJZHWIXJCJ-UHFFFAOYSA-N 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 229950010390 irampanel Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229960003729 mesuximide Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical compound C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229950004608 talampanel Drugs 0.000 description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229940035305 topamax Drugs 0.000 description 2
- OPJHWTKDQYKYHL-UHFFFAOYSA-N 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxylic acid Chemical compound N1=NC(C(=O)O)=CN1CC1=C(F)C=CC=C1F OPJHWTKDQYKYHL-UHFFFAOYSA-N 0.000 description 1
- HUNSEMNKAFDVDI-UHFFFAOYSA-N 4-(8-chloro-2-methyl-11h-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline;dihydrochloride Chemical compound Cl.Cl.C12=CC(Cl)=CC=C2CC2=NC(C)=CN2N=C1C1=CC=C(N)C=C1 HUNSEMNKAFDVDI-UHFFFAOYSA-N 0.000 description 1
- AEFZZVQZPBFFPN-UHFFFAOYSA-N 7-[4-[(4-carboxyphenyl)carbamoyloxymethyl]imidazol-1-yl]-3-oxo-6-(trifluoromethyl)-4h-quinoxaline-2-carboxylic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC(=O)OCC1=CN(C=2C(=CC=3NC(=O)C(C(O)=O)=NC=3C=2)C(F)(F)F)C=N1 AEFZZVQZPBFFPN-UHFFFAOYSA-N 0.000 description 1
- 208000024255 Audiogenic seizures Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- WLWFNJKHKGIJNW-UHFFFAOYSA-N Phensuximide Chemical compound O=C1N(C)C(=O)CC1C1=CC=CC=C1 WLWFNJKHKGIJNW-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000011461 current therapy Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229960004227 phensuximide Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229960002393 primidone Drugs 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229960003014 rufinamide Drugs 0.000 description 1
- POGQSBRIGCQNEG-UHFFFAOYSA-N rufinamide Chemical compound N1=NC(C(=O)N)=CN1CC1=C(F)C=CC=C1F POGQSBRIGCQNEG-UHFFFAOYSA-N 0.000 description 1
- 230000002226 simultaneous effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0307860.7A GB0307860D0 (en) | 2003-04-04 | 2003-04-04 | Organic compounds |
| GB0307860.7 | 2003-04-04 | ||
| PCT/EP2004/003518 WO2004087161A1 (en) | 2003-04-04 | 2004-04-02 | Combinations comprising anti-epileptic drugs for the treatment of neurological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2521274A1 true CA2521274A1 (en) | 2004-10-14 |
Family
ID=9956223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002521274A Abandoned CA2521274A1 (en) | 2003-04-04 | 2004-04-02 | Combinations comprising anti-epileptic drugs for the treatment of neurological disorders |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060194766A1 (https=) |
| EP (1) | EP1620103A1 (https=) |
| JP (1) | JP2006522062A (https=) |
| CN (1) | CN100546581C (https=) |
| AU (1) | AU2004226825B2 (https=) |
| BR (1) | BRPI0409170A (https=) |
| CA (1) | CA2521274A1 (https=) |
| GB (1) | GB0307860D0 (https=) |
| MX (1) | MXPA05010707A (https=) |
| WO (1) | WO2004087161A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| CA2690110A1 (en) * | 2007-07-13 | 2009-01-22 | Eisai R&D Management Co., Ltd. | Ampa receptor antagonists for neuropathic pain |
| WO2009015244A1 (en) * | 2007-07-23 | 2009-01-29 | Synosia Therapeutics | Rufinamide for the treatment of post-traumatic stress disorder |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| PT3061821T (pt) | 2009-07-22 | 2019-09-05 | PureTech Health LLC | Composições para tratamento de distúrbios melhorados por ativação de recetores muscarínicos |
| KR102408292B1 (ko) | 2018-09-28 | 2022-06-10 | 카루나 세러퓨틱스 인코포레이티드 | 무스카린성 수용체 활성화에 의해 개선된 장애의 치료를 위한 조성물 및 방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB864536A (en) * | 1957-11-06 | 1961-04-06 | Sapos S A Lab | ª‡-ethyl-phenylacetylurea |
| GB1028234A (en) * | 1964-01-06 | 1966-05-04 | Ici Ltd | New pharmaceutical compositions comprising 5-aminodibenzocycloheptene derivatives |
| JPH02502546A (ja) * | 1987-12-22 | 1990-08-16 | ファーカニー、ジョン ダブリュ | 抗ひきつけ剤組成物および方法のためのデキストロルファン相乗的協力剤 |
| US5095033A (en) * | 1991-03-01 | 1992-03-10 | Laboratoires Biocodex | Method for treating epilepsy |
| IT1261808B (it) * | 1993-07-06 | 1996-06-03 | Impiego di l-carnitina o acido l-carnitine e valproato nel trattamentodei disosrdini convulsivi | |
| EP0946597B1 (en) * | 1996-10-19 | 2003-08-13 | University Of Wales, Bangor | Preparation of chemically reactive starch |
| CA2269807C (en) * | 1996-10-24 | 2007-04-10 | Novartis Ag | Substituted aminoalkanephosphonic acids |
| US6306909B1 (en) * | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| CN1265889A (zh) * | 1999-03-06 | 2000-09-13 | 王学勇 | 一种治疗癫痫病的药物 |
| AR026610A1 (es) * | 1999-12-01 | 2003-02-19 | Ucb Sa | Un derivado pirrolidinacetamida solo o en combinacion para tratamiento de desordenes del sistema nervioso central |
| US6191117B1 (en) * | 2000-07-10 | 2001-02-20 | Walter E. Kozachuk | Methods of producing weight loss and treatment of obesity |
| ES2314111T3 (es) * | 2001-11-12 | 2009-03-16 | Novartis Ag | Monohidroxicarbamezepina para uso en la preparacion de un medicamento para el tratamiento del trastorno de afectivo y de atencion y dolor neuropatico. |
-
2003
- 2003-04-04 GB GBGB0307860.7A patent/GB0307860D0/en not_active Ceased
-
2004
- 2004-04-02 CN CNB2004800092188A patent/CN100546581C/zh not_active Expired - Fee Related
- 2004-04-02 MX MXPA05010707A patent/MXPA05010707A/es not_active Application Discontinuation
- 2004-04-02 CA CA002521274A patent/CA2521274A1/en not_active Abandoned
- 2004-04-02 AU AU2004226825A patent/AU2004226825B2/en not_active Ceased
- 2004-04-02 JP JP2006504970A patent/JP2006522062A/ja active Pending
- 2004-04-02 US US10/550,381 patent/US20060194766A1/en not_active Abandoned
- 2004-04-02 WO PCT/EP2004/003518 patent/WO2004087161A1/en not_active Ceased
- 2004-04-02 BR BRPI0409170-1A patent/BRPI0409170A/pt not_active IP Right Cessation
- 2004-04-02 EP EP04725366A patent/EP1620103A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05010707A (es) | 2005-12-12 |
| JP2006522062A (ja) | 2006-09-28 |
| CN100546581C (zh) | 2009-10-07 |
| GB0307860D0 (en) | 2003-05-14 |
| AU2004226825B2 (en) | 2007-08-16 |
| US20060194766A1 (en) | 2006-08-31 |
| WO2004087161A1 (en) | 2004-10-14 |
| BRPI0409170A (pt) | 2006-04-11 |
| EP1620103A1 (en) | 2006-02-01 |
| AU2004226825A1 (en) | 2004-10-14 |
| CN1767832A (zh) | 2006-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2035029B1 (en) | Peptide compounds for treating refractory status epilepticus | |
| JP2007517901A (ja) | 体重の減少に作用する鎮痙剤及び抗精神病剤の組成物 | |
| US20080214592A1 (en) | Methods of treating anxiety disorders | |
| US20100179129A1 (en) | Compositions of an anticonvulsant and mirtazapine to prevent weight gain | |
| JP2003507421A (ja) | トラマドール物質及び抗痙攣薬を含んで成る組成物 | |
| JP2007262096A (ja) | 痙攣または発作を処置または予防するための組成物および方法 | |
| JP2009539996A (ja) | 腎機能障害を持つ個体における利尿改善方法 | |
| CN101420958A (zh) | 共投与腺苷a1受体拮抗剂和抗惊厥药 | |
| AU2004226825B2 (en) | Combinations comprising anti-epileptic drugs for the treatment of neurological disorders | |
| CA2522971A1 (en) | Method of improved diuresis in individuals with impaired renal function | |
| AU2004290890B2 (en) | Combinations comprising AMPA receptor antagonists for the treatment of schizophrenia | |
| JP7265526B2 (ja) | てんかん治療剤 | |
| AU2003267557B2 (en) | Treatment of dyskinesia | |
| CN101094671A (zh) | 包含腺苷a1受体拮抗剂和醛固酮抑制剂的组合疗法 | |
| WO1995028177A1 (en) | Medicinal composition for treating tardive dyskinesia and utilization thereof | |
| WO2005049042A1 (en) | Combinations comprising ampa receptor antagonists for the treatment of tinnitus | |
| WO2005049041A1 (en) | Combinations comprising ampa receptor antagonists for the treatment of anxiety disorders | |
| WO2005049039A1 (en) | Combinations comprising ampa receptors antagonists for the treatment of affective and attention deficit disorders | |
| WO2005094797A2 (en) | Use of ampa-receptor antagonists for treating dementia | |
| WO2005039593A1 (en) | Combinations comprising ampa receptor antagonists for the treatment of neuropathic pain | |
| WO2005039594A1 (en) | Combinations comprising ampa receptor antagonists for the treatment of myopia | |
| MXPA06007770A (en) | Compositions of an anticonvulsant and an antipsychotic drug for affecting weight loss | |
| EP1932529A1 (en) | Method of improved diuresis in individuals with impaired renal function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |