CA2520392C - Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding - Google Patents
Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding Download PDFInfo
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- CA2520392C CA2520392C CA2520392A CA2520392A CA2520392C CA 2520392 C CA2520392 C CA 2520392C CA 2520392 A CA2520392 A CA 2520392A CA 2520392 A CA2520392 A CA 2520392A CA 2520392 C CA2520392 C CA 2520392C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45729303P | 2003-03-26 | 2003-03-26 | |
| US60/457,293 | 2003-03-26 | ||
| PCT/US2004/009399 WO2004087059A2 (en) | 2003-03-26 | 2004-03-26 | Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2520392A1 CA2520392A1 (en) | 2004-10-14 |
| CA2520392C true CA2520392C (en) | 2014-08-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2520392A Expired - Fee Related CA2520392C (en) | 2003-03-26 | 2004-03-26 | Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding |
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| US (1) | US9006388B2 (enExample) |
| EP (1) | EP1610808A4 (enExample) |
| JP (2) | JP5503837B2 (enExample) |
| CA (1) | CA2520392C (enExample) |
| WO (1) | WO2004087059A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8980646B2 (en) | 2003-03-26 | 2015-03-17 | Sudhir Paul | Proteolytic and covalent antibodies |
| JP5503837B2 (ja) * | 2003-03-26 | 2014-05-28 | ポール，サッドヒル | 非共有結合により誘導される求核性タンパク質へのリガンドの共有結合 |
| WO2004087738A2 (en) | 2003-03-27 | 2004-10-14 | The University Of Texas | Lupus antibodies for passive immunotherapy of hiv/aids |
| BRPI0813948B8 (pt) * | 2007-07-10 | 2021-05-25 | Medy Tox Inc | composição líquida farmacêutica de toxina botulínica com estabilidade melhorada |
| CN105574346A (zh) * | 2008-09-05 | 2016-05-11 | 新基阿维罗米克斯研究公司 | 多肽偶联物与不可逆抑制剂的设计方法和检测方法 |
| NZ598705A (en) | 2009-09-16 | 2014-06-27 | Celgene Avilomics Res Inc | Protein kinase conjugates and inhibitors |
| JP2013516422A (ja) | 2009-12-30 | 2013-05-13 | アビラ セラピューティクス， インコーポレイテッド | タンパク質のリガンド−指向性共有的修飾 |
| EP3511424B1 (en) | 2012-08-03 | 2023-10-18 | University Of Washington Through Its Center For Commercialization | Compositions and methods for improving nanopore sequencing |
| HUE046449T2 (hu) | 2016-09-13 | 2020-03-30 | Allergan Inc | Stabilizált, nem fehérje eredetû, clostridiális toxin készítmények |
Family Cites Families (26)
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| US5952462A (en) | 1983-11-29 | 1999-09-14 | Igen International Inc. | Transition state analogs |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US5695927A (en) | 1988-03-31 | 1997-12-09 | The University Of Arizona, Department Of Internal Medicine, Section Of Hematology And Oncology | Monoclonal antibodies specific for HIV and the hybridomas for production thereof |
| US5445960A (en) | 1988-03-31 | 1995-08-29 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Monoclonal antibodies specific for HIV and hybridomas for their production |
| JP2809533B2 (ja) * | 1991-01-31 | 1998-10-08 | 壽之 松尾 | Ｃｎｐ類似体ペプチド |
| DE122004000008I1 (de) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
| US5801149A (en) * | 1991-06-19 | 1998-09-01 | Joslin D-Abetes Center, Inc. | Inhibition of signal transduction molecules |
| WO1993015751A1 (en) * | 1992-02-14 | 1993-08-19 | Merck & Co., Inc. | CHIMERIC TOXINS BINDING TO THE GnRH RECEPTOR |
| US5574142A (en) * | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| US5952307A (en) * | 1994-01-21 | 1999-09-14 | Georgia Tech Research Corp. | Basic α-aminoalkylphosphonate derivatives |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5543396A (en) * | 1994-04-28 | 1996-08-06 | Georgia Tech Research Corp. | Proline phosphonate derivatives |
| US5916877A (en) * | 1994-10-18 | 1999-06-29 | Georgia Tech Research Corporation | Fluorescent 1-peptidylaminoalkanephosphonate derivatives |
| CN1165344C (zh) | 1995-07-21 | 2004-09-08 | 内布拉斯卡大学评议会 | 用于催化水解HIVgp120的组合物及其制备方法和用途 |
| US6855804B2 (en) | 1998-03-23 | 2005-02-15 | Board Of Regents, The University Of Texas System | Covalently reactive transition state analogs and methods of use thereof |
| US6235714B1 (en) * | 1998-03-23 | 2001-05-22 | Sudhir Paul | Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses |
| EP1085880A2 (en) * | 1998-06-11 | 2001-03-28 | Cerus Corporation | Use of alkylating compounds for inhibiting proliferation of arterial smooth muscle cells |
| WO2001017614A2 (en) * | 1999-09-07 | 2001-03-15 | Conjuchem, Inc. | Methods and compositions containing succinimide or maleimide derivatives of antineoplastic agents |
| US6406863B1 (en) | 2000-06-23 | 2002-06-18 | Genetastix Corporation | High throughput generation and screening of fully human antibody repertoire in yeast |
| WO2002079223A2 (en) * | 2001-03-31 | 2002-10-10 | Board Of Regents, The University Of Texas System | Covalently reactive transition state analogs and methods of use thereof |
| JP5503837B2 (ja) * | 2003-03-26 | 2014-05-28 | ポール，サッドヒル | 非共有結合により誘導される求核性タンパク質へのリガンドの共有結合 |
| US8980646B2 (en) | 2003-03-26 | 2015-03-17 | Sudhir Paul | Proteolytic and covalent antibodies |
| WO2004087738A2 (en) | 2003-03-27 | 2004-10-14 | The University Of Texas | Lupus antibodies for passive immunotherapy of hiv/aids |
| EP2091973A4 (en) * | 2006-11-09 | 2010-08-04 | Sudhir Paul | ANTIBODIES TO BINARY EPITOPES AND B-CELL SUPERANTIGEN IMMUNOSTIMULANTS |
| US9969797B2 (en) * | 2008-04-23 | 2018-05-15 | Covalent Bioscience Incorporated | Immunoglobulins directed to bacterial, viral and endogenous polypeptides |
| US20120121633A1 (en) * | 2010-07-16 | 2012-05-17 | Sudhir Paul | Hiv cd4 binding site based covalent immunogen compositions |
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2004
- 2004-03-26 JP JP2006509376A patent/JP5503837B2/ja not_active Expired - Fee Related
- 2004-03-26 CA CA2520392A patent/CA2520392C/en not_active Expired - Fee Related
- 2004-03-26 EP EP04758449A patent/EP1610808A4/en not_active Ceased
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2520392A1 (en) | 2004-10-14 |
| WO2004087059A3 (en) | 2005-07-21 |
| JP2007527373A (ja) | 2007-09-27 |
| US9006388B2 (en) | 2015-04-14 |
| EP1610808A2 (en) | 2006-01-04 |
| US20070179083A1 (en) | 2007-08-02 |
| WO2004087059A2 (en) | 2004-10-14 |
| JP5827003B2 (ja) | 2015-12-02 |
| JP2011105724A (ja) | 2011-06-02 |
| JP5503837B2 (ja) | 2014-05-28 |
| EP1610808A4 (en) | 2011-04-06 |
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