CA2511625A1 - Modified vaccinia ankara expressing p53 in cancer immunotherapy - Google Patents
Modified vaccinia ankara expressing p53 in cancer immunotherapy Download PDFInfo
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- CA2511625A1 CA2511625A1 CA002511625A CA2511625A CA2511625A1 CA 2511625 A1 CA2511625 A1 CA 2511625A1 CA 002511625 A CA002511625 A CA 002511625A CA 2511625 A CA2511625 A CA 2511625A CA 2511625 A1 CA2511625 A1 CA 2511625A1
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| US7674456B2 (en) * | 2004-06-14 | 2010-03-09 | Charles Wiseman | Breast cancer cell lines and uses thereof |
| NO347468B1 (no) | 2005-02-23 | 2023-11-13 | Bavarian Nordic As | Et modifisert Vacciniavirus Ankara (MVA) for anvendelse ved immunisering. |
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| CN1919873B (zh) * | 2005-08-25 | 2012-05-30 | 北京沙东生物技术有限公司 | 包含人HSP70 ATPase结构域与哺乳动物p53蛋白的融合蛋白及其应用 |
| JP6092497B2 (ja) | 2006-03-30 | 2017-03-08 | ユニバーシティー オブ カリフォルニア | 抗ｃｔｌａ−４抗体の限局性分泌のための方法および組成物 |
| US20090035360A1 (en) * | 2007-05-24 | 2009-02-05 | Dominique Ingrid Lemoine | Lyophilised antigen composition |
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| US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
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| CR20200476A (es) | 2015-05-20 | 2020-12-02 | Dana Farber Cancer Inst Inc | ANTÍGENOS COMPARTIDOS (Divisional 2017-0584) |
| CN108884159A (zh) * | 2015-11-07 | 2018-11-23 | 茂体外尔公司 | 用于癌症治疗的包含肿瘤抑制基因治疗和免疫检查点阻断的组合物 |
| SG11201807051VA (en) | 2016-02-25 | 2018-09-27 | Memorial Sloan Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy |
| IL261321B2 (en) | 2016-02-25 | 2023-12-01 | Memorial Sloan Kettering Cancer Center | Recombinant MVA or MVADELE3L expressing human FLT3L and their use as immunotherapeutic agents against solid tumors |
| WO2018107011A1 (en) * | 2016-12-08 | 2018-06-14 | City Of Hope | P53-targeting vaccines and pd-1 pathway inhibitors and methods of use thereof |
| EP3551226A1 (en) * | 2016-12-12 | 2019-10-16 | MultiVir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| US20200085758A1 (en) | 2016-12-16 | 2020-03-19 | The Brigham And Women's Hospital, Inc. | Co-delivery of nucleic acids for simultaneous suppression and expression of target genes |
| WO2018140391A1 (en) | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| WO2018209315A1 (en) | 2017-05-12 | 2018-11-15 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| US20210177964A1 (en) * | 2017-11-06 | 2021-06-17 | Memorial Sloan Kettering Cancer Center | Heat-inactivated vaccinia virus as a vaccine immune adjuvant |
| AU2019322487B2 (en) | 2018-03-19 | 2024-04-18 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
| CN116162654A (zh) | 2018-09-15 | 2023-05-26 | 纪念斯隆凯特琳癌症中心 | 用于癌症免疫疗法的重组痘病毒 |
| US12274784B2 (en) | 2018-10-12 | 2025-04-15 | Synergene Therapeutics, Inc. | Methods for reducing side effects of immunotherapy |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| KR20230028484A (ko) * | 2020-06-24 | 2023-02-28 | 피엠브이 파마슈티컬스 인코포레이티드 | 암의 치료를 위한 병용 요법 |
| CN115537399B (zh) * | 2022-09-22 | 2025-02-11 | 沈阳药科大学 | 修饰化外泌体及其制法和外泌体联合pd-1抗体的原位喷雾水凝胶和应用 |
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| CA1341245C (en) * | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| US6410010B1 (en) * | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
| US6045802A (en) * | 1994-10-03 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule |
| CN1723285B (zh) * | 2003-02-18 | 2013-01-02 | 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 | 重组的mva及其产生方法 |
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- 2003-12-22 JP JP2005510053A patent/JP2006512097A/ja not_active Withdrawn
- 2003-12-22 AU AU2003297499A patent/AU2003297499A1/en not_active Abandoned
- 2003-12-22 EP EP03814346A patent/EP1575611A4/en not_active Withdrawn
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| US7563448B2 (en) | 2009-07-21 |
| EP1575611A2 (en) | 2005-09-21 |
| EP1575611A4 (en) | 2007-10-03 |
| WO2004058801A2 (en) | 2004-07-15 |
| US7256037B2 (en) | 2007-08-14 |
| WO2004058801A3 (en) | 2004-11-11 |
| US20040208850A1 (en) | 2004-10-21 |
| US20070224195A1 (en) | 2007-09-27 |
| JP2006512097A (ja) | 2006-04-13 |
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