CA2511530C - Night-time oral insulin therapy - Google Patents
Night-time oral insulin therapy Download PDFInfo
- Publication number
- CA2511530C CA2511530C CA2511530A CA2511530A CA2511530C CA 2511530 C CA2511530 C CA 2511530C CA 2511530 A CA2511530 A CA 2511530A CA 2511530 A CA2511530 A CA 2511530A CA 2511530 C CA2511530 C CA 2511530C
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- CA
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- Prior art keywords
- insulin
- treating
- patient
- levels
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- MHXBHWLGRWOABW-UHFFFAOYSA-N tetradecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940045860 white wax Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43819503P | 2003-01-06 | 2003-01-06 | |
| US43845103P | 2003-01-06 | 2003-01-06 | |
| US60/438,451 | 2003-01-06 | ||
| US60/438,195 | 2003-01-06 | ||
| US47896703P | 2003-06-16 | 2003-06-16 | |
| US60/478,967 | 2003-06-16 | ||
| PCT/US2004/000273 WO2004062587A2 (en) | 2003-01-06 | 2004-01-06 | Night-time oral insulin therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2511530A1 CA2511530A1 (en) | 2004-07-29 |
| CA2511530C true CA2511530C (en) | 2013-07-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2511530A Expired - Fee Related CA2511530C (en) | 2003-01-06 | 2004-01-06 | Night-time oral insulin therapy |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7384914B2 (enExample) |
| EP (1) | EP1592438B1 (enExample) |
| JP (1) | JP5452843B2 (enExample) |
| AU (1) | AU2004204727B8 (enExample) |
| CA (1) | CA2511530C (enExample) |
| ES (1) | ES2465496T3 (enExample) |
| NZ (1) | NZ541058A (enExample) |
| WO (1) | WO2004062587A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4417113B2 (ja) | 2002-02-20 | 2010-02-17 | エミスフェアー・テクノロジーズ・インク | Ｇｌｐ−１分子の投与方法 |
| WO2004080401A2 (en) * | 2003-03-06 | 2004-09-23 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
| US20050203001A1 (en) | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| NZ551196A (en) * | 2004-05-14 | 2010-08-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| NZ551455A (en) | 2004-05-19 | 2012-03-30 | Emisphere Tech Inc | Acyclovir formulations |
| EP2248531A1 (en) * | 2004-08-03 | 2010-11-10 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
| AU2005321803B2 (en) | 2004-12-29 | 2012-02-09 | Emisphere Technologies, Inc. | Pharmaceutical formulations of gallium salts |
| WO2006076692A1 (en) | 2005-01-12 | 2006-07-20 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
| WO2006125762A1 (en) * | 2005-05-25 | 2006-11-30 | Novo Nordisk A/S | Stabilized polypeptide formulations |
| CN101180081B (zh) * | 2005-05-25 | 2015-08-26 | 诺沃-诺迪斯克有限公司 | 稳定的多肽制剂 |
| WO2007121318A2 (en) | 2006-04-12 | 2007-10-25 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| US8771712B2 (en) | 2006-05-09 | 2014-07-08 | Emisphere Technologies, Inc. | Topical administration of acyclovir |
| US9364502B2 (en) | 2006-06-28 | 2016-06-14 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
| WO2008132731A2 (en) * | 2007-04-26 | 2008-11-06 | Oramed Pharmaceuticals, Inc | Methods and compositions for rectal administration of insulin |
| IL188647A0 (en) * | 2008-01-08 | 2008-11-03 | Orina Gribova | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
| AU2009283821B2 (en) | 2008-08-18 | 2014-05-29 | Entera Bio Ltd. | Methods and compositions for oral administration of proteins |
| US9060932B2 (en) | 2009-07-09 | 2015-06-23 | Oshadi Drug Administration Ltd. | Matrix carrier compositions, methods and uses |
| WO2011017346A2 (en) | 2009-08-03 | 2011-02-10 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
| US20240315972A1 (en) | 2021-07-12 | 2024-09-26 | Zidkiyahu Simenhaus | Protein containing bio-active compositions comprising cellulose microparticle carriers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863896A (en) | 1984-05-03 | 1989-09-05 | Technology Unlimited, Inc. | Diabetic control by combined insulin forms |
| RU2066551C1 (ru) * | 1994-03-23 | 1996-09-20 | Институт нефтехимического синтеза РАН | Способ получения инсулинсодержащих полимерных гидрогелей |
| US5780243A (en) * | 1996-06-28 | 1998-07-14 | Thaco Research, Ltd. | Methods for the quantitative analysis of organic compounds |
| SE520392C2 (sv) * | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
| US6197340B1 (en) * | 1998-05-28 | 2001-03-06 | Medical Research Institute | Controlled release lipoic acid |
| US7227033B2 (en) * | 2002-01-09 | 2007-06-05 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl) amino] butanoate |
| CZ303736B6 (cs) * | 2000-06-29 | 2013-04-17 | Emisphere Technologies, Inc. | Slouceniny a prostredky pro zavádení aktivních cinidel |
| BR0114799A (pt) * | 2000-09-06 | 2003-12-30 | Emisphere Tech Inc | Compostos de ácido cianofenoxi carboxìlico e composições para liberar agentes ativos |
| US20020147135A1 (en) * | 2000-12-21 | 2002-10-10 | Oliver Schnell | Method and device for producing an adapted travel treatment plan for administering a medicine in the event of a long-haul journey |
| US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US20030198666A1 (en) * | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
| US7137951B2 (en) * | 2002-10-23 | 2006-11-21 | Joseph Pilarski | Method of food and insulin dose management for a diabetic subject |
| NZ551196A (en) | 2004-05-14 | 2010-08-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
-
2004
- 2004-01-06 US US10/541,433 patent/US7384914B2/en not_active Expired - Lifetime
- 2004-01-06 ES ES04700388.4T patent/ES2465496T3/es not_active Expired - Lifetime
- 2004-01-06 EP EP04700388.4A patent/EP1592438B1/en not_active Expired - Lifetime
- 2004-01-06 CA CA2511530A patent/CA2511530C/en not_active Expired - Fee Related
- 2004-01-06 NZ NZ541058A patent/NZ541058A/en not_active IP Right Cessation
- 2004-01-06 WO PCT/US2004/000273 patent/WO2004062587A2/en not_active Ceased
- 2004-01-06 JP JP2006500813A patent/JP5452843B2/ja not_active Expired - Fee Related
- 2004-01-06 AU AU2004204727A patent/AU2004204727B8/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NZ541058A (en) | 2008-06-30 |
| ES2465496T3 (es) | 2014-06-05 |
| AU2004204727A1 (en) | 2004-07-29 |
| US20060178296A1 (en) | 2006-08-10 |
| HK1085133A1 (en) | 2006-08-18 |
| US7384914B2 (en) | 2008-06-10 |
| AU2004204727B2 (en) | 2006-10-19 |
| AU2004204727B8 (en) | 2006-11-09 |
| EP1592438A4 (en) | 2009-07-08 |
| WO2004062587A3 (en) | 2005-04-28 |
| EP1592438A2 (en) | 2005-11-09 |
| CA2511530A1 (en) | 2004-07-29 |
| JP5452843B2 (ja) | 2014-03-26 |
| JP2006515620A (ja) | 2006-06-01 |
| WO2004062587A2 (en) | 2004-07-29 |
| EP1592438B1 (en) | 2014-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20220106 |