CA2508917A1 - Therapeutic agents - Google Patents
Therapeutic agents Download PDFInfo
- Publication number
- CA2508917A1 CA2508917A1 CA002508917A CA2508917A CA2508917A1 CA 2508917 A1 CA2508917 A1 CA 2508917A1 CA 002508917 A CA002508917 A CA 002508917A CA 2508917 A CA2508917 A CA 2508917A CA 2508917 A1 CA2508917 A1 CA 2508917A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- amino
- carbamoyl
- heterocyclyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003814 drug Substances 0.000 title claims description 18
- 229940124597 therapeutic agent Drugs 0.000 title description 3
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- -1 trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl Chemical group 0.000 claims description 179
- 125000001424 substituent group Chemical group 0.000 claims description 45
- 229910052739 hydrogen Inorganic materials 0.000 claims description 42
- 239000001257 hydrogen Substances 0.000 claims description 42
- 150000003839 salts Chemical class 0.000 claims description 37
- 125000000623 heterocyclic group Chemical group 0.000 claims description 34
- 125000005236 alkanoylamino group Chemical group 0.000 claims description 32
- 125000005843 halogen group Chemical group 0.000 claims description 30
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 29
- 125000003545 alkoxy group Chemical group 0.000 claims description 28
- 125000003282 alkyl amino group Chemical group 0.000 claims description 28
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 27
- 125000003118 aryl group Chemical group 0.000 claims description 25
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 24
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 229910052760 oxygen Inorganic materials 0.000 claims description 22
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- 125000004414 alkyl thio group Chemical group 0.000 claims description 19
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- 229960002066 vinorelbine Drugs 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0230089.5A GB0230089D0 (en) | 2002-12-24 | 2002-12-24 | Therapeutic agents |
| GB0230089.5 | 2002-12-24 | ||
| PCT/GB2003/005568 WO2004058776A1 (en) | 2002-12-24 | 2003-12-19 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2508917A1 true CA2508917A1 (en) | 2004-07-15 |
Family
ID=9950374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002508917A Abandoned CA2508917A1 (en) | 2002-12-24 | 2003-12-19 | Therapeutic agents |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20060069109A1 (enExample) |
| EP (1) | EP1575963B1 (enExample) |
| JP (1) | JP2006515593A (enExample) |
| KR (1) | KR20050087852A (enExample) |
| CN (1) | CN1751052A (enExample) |
| AT (1) | ATE394403T1 (enExample) |
| AU (1) | AU2003295135A1 (enExample) |
| BR (1) | BR0317708A (enExample) |
| CA (1) | CA2508917A1 (enExample) |
| DE (1) | DE60320849D1 (enExample) |
| ES (1) | ES2305548T3 (enExample) |
| GB (1) | GB0230089D0 (enExample) |
| MX (1) | MXPA05006921A (enExample) |
| NO (1) | NO20052989L (enExample) |
| WO (1) | WO2004058776A1 (enExample) |
| ZA (1) | ZA200504827B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| GB0502418D0 (en) * | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
| SI1973545T1 (sl) * | 2005-12-23 | 2013-04-30 | Ariad Pharmaceuticals, Inc. | Spojine bicikličnega heteroarila |
| ES2761180T3 (es) * | 2005-12-23 | 2020-05-19 | Ariad Pharma Inc | Compuestos bicíclicos de heteroarilo |
| AU2015210454B2 (en) * | 2005-12-23 | 2016-10-27 | Takeda Pharmaceuticals U.S.A., Inc. | Bicyclic heteroaryl compounds |
| US8278307B2 (en) | 2006-05-08 | 2012-10-02 | Ariad Pharmaceuticals, Inc. | Monocyclic Heteroaryl compounds |
| WO2007133560A2 (en) | 2006-05-08 | 2007-11-22 | Ariad Pharmaceuticals, Inc. | Acetylenic heteroaryl compounds |
| EP2120964A2 (en) | 2006-12-15 | 2009-11-25 | Abraxis BioScience, Inc. | Triazine derivatives and their therapeutical applications |
| CA2729012A1 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| JP5590040B2 (ja) | 2008-11-12 | 2014-09-17 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのピラジノピラジンおよび誘導体 |
| JP2012529517A (ja) | 2009-06-09 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | ベンジル置換トリアジン誘導体類及びそれらの治療応用 |
| KR101457027B1 (ko) | 2009-06-09 | 2014-10-31 | 캘리포니아 캐피탈 에쿼티, 엘엘씨 | 트리아진 유도체와 이들의 치료적 용도 |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2508511A1 (en) * | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| BR112014028006A2 (pt) * | 2012-05-30 | 2017-06-27 | Hoffmann La Roche | heterociclos de pirrolidino |
| CA3167093A1 (en) | 2012-12-12 | 2014-06-12 | Ariad Pharmaceuticals, Inc. | Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| DK4013502T3 (da) * | 2019-08-16 | 2025-11-10 | Cyclacel Pharmaceuticals Inc | Fremgangsmåde til fremstillingen af et pyrimidino-diazepinderivat |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ517758A (en) * | 1999-09-17 | 2004-06-25 | Abbott Gmbh & Co | Pyrazolopyrimidines useful as therapeutic agents |
| KR20020050294A (ko) * | 1999-11-22 | 2002-06-26 | 피터 기딩스 | 신규화합물 |
| EP1343779B1 (en) * | 2000-11-20 | 2007-06-27 | Smithkline Beecham Corporation | Novel compounds |
| DE60304718T2 (de) * | 2002-08-06 | 2007-04-26 | Astrazeneca Ab | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität |
-
2002
- 2002-12-24 GB GBGB0230089.5A patent/GB0230089D0/en not_active Ceased
-
2003
- 2003-12-19 WO PCT/GB2003/005568 patent/WO2004058776A1/en not_active Ceased
- 2003-12-19 AT AT03786136T patent/ATE394403T1/de not_active IP Right Cessation
- 2003-12-19 BR BR0317708-4A patent/BR0317708A/pt not_active Application Discontinuation
- 2003-12-19 EP EP03786136A patent/EP1575963B1/en not_active Expired - Lifetime
- 2003-12-19 ES ES03786136T patent/ES2305548T3/es not_active Expired - Lifetime
- 2003-12-19 DE DE60320849T patent/DE60320849D1/de not_active Expired - Fee Related
- 2003-12-19 JP JP2004563345A patent/JP2006515593A/ja active Pending
- 2003-12-19 CN CNA2003801098327A patent/CN1751052A/zh active Pending
- 2003-12-19 US US10/540,348 patent/US20060069109A1/en not_active Abandoned
- 2003-12-19 AU AU2003295135A patent/AU2003295135A1/en not_active Abandoned
- 2003-12-19 KR KR1020057011870A patent/KR20050087852A/ko not_active Withdrawn
- 2003-12-19 CA CA002508917A patent/CA2508917A1/en not_active Abandoned
- 2003-12-19 MX MXPA05006921A patent/MXPA05006921A/es unknown
-
2005
- 2005-06-13 ZA ZA200504827A patent/ZA200504827B/en unknown
- 2005-06-17 NO NO20052989A patent/NO20052989L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200504827B (en) | 2006-04-26 |
| EP1575963B1 (en) | 2008-05-07 |
| BR0317708A (pt) | 2005-11-22 |
| US20060069109A1 (en) | 2006-03-30 |
| JP2006515593A (ja) | 2006-06-01 |
| AU2003295135A1 (en) | 2004-07-22 |
| KR20050087852A (ko) | 2005-08-31 |
| EP1575963A1 (en) | 2005-09-21 |
| NO20052989L (no) | 2005-07-21 |
| ATE394403T1 (de) | 2008-05-15 |
| DE60320849D1 (de) | 2008-06-19 |
| ES2305548T3 (es) | 2008-11-01 |
| CN1751052A (zh) | 2006-03-22 |
| MXPA05006921A (es) | 2005-08-18 |
| NO20052989D0 (no) | 2005-06-17 |
| WO2004058776A1 (en) | 2004-07-15 |
| GB0230089D0 (en) | 2003-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |