CA2501958A1 - Polynucleotides and polypeptides derived from lactobacillus rhamnosus hn001 - Google Patents

Info

Publication number

CA2501958A1

CA2501958A1 CA002501958A CA2501958A CA2501958A1 CA 2501958 A1 CA2501958 A1 CA 2501958A1 CA 002501958 A CA002501958 A CA 002501958A CA 2501958 A CA2501958 A CA 2501958A CA 2501958 A1 CA2501958 A1 CA 2501958A1

Authority

CA

Canada

Prior art keywords

ltered

genetic

seq

polynucleotide

sequences

Prior art date

2002-10-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 102000040430 polynucleotide Human genes 0.000 title claims abstract description 168
• 108091033319 polynucleotide Proteins 0.000 title claims abstract description 167
• 239000002157 polynucleotide Substances 0.000 title claims abstract description 167
• 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 120
• 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 104
• 229920001184 polypeptide Polymers 0.000 title claims abstract description 98
• 241000254697 Lactobacillus rhamnosus HN001 Species 0.000 title claims 3
• 230000002068 genetic effect Effects 0.000 claims abstract description 284
• 238000000034 method Methods 0.000 claims abstract description 151
• 239000003155 DNA primer Substances 0.000 claims abstract description 9
• 108020005187 Oligonucleotide Probes Proteins 0.000 claims abstract description 9
• 239000002751 oligonucleotide probe Substances 0.000 claims abstract description 9
• 244000005700 microbiome Species 0.000 claims abstract description 8
• 239000000796 flavoring agent Substances 0.000 claims description 229
• 235000019634 flavors Nutrition 0.000 claims description 227
• 108090000623 proteins and genes Proteins 0.000 claims description 219
• 230000004083 survival effect Effects 0.000 claims description 204
• 238000004519 manufacturing process Methods 0.000 claims description 165
• 239000000463 material Substances 0.000 claims description 113
• 239000006041 probiotic Substances 0.000 claims description 102
• 230000000529 probiotic effect Effects 0.000 claims description 102
• 235000018291 probiotics Nutrition 0.000 claims description 102
• 238000003860 storage Methods 0.000 claims description 100
• 108020001507 fusion proteins Proteins 0.000 claims description 95
• 102000037865 fusion proteins Human genes 0.000 claims description 95
• 241000894006 Bacteria Species 0.000 claims description 84
• 239000000047 product Substances 0.000 claims description 71
• 230000009261 transgenic effect Effects 0.000 claims description 34
• 230000036541 health Effects 0.000 claims description 28
• 230000000694 effects Effects 0.000 claims description 26
• 238000011161 development Methods 0.000 claims description 25
• 235000013351 cheese Nutrition 0.000 claims description 21
• 241000186660 Lactobacillus Species 0.000 claims description 20
• 229940039696 lactobacillus Drugs 0.000 claims description 16
• 239000002773 nucleotide Substances 0.000 claims description 14
• 125000003729 nucleotide group Chemical group 0.000 claims description 13
• 230000000295 complement effect Effects 0.000 claims description 12
• 150000001875 compounds Chemical class 0.000 claims description 12
• 239000000203 mixture Substances 0.000 claims description 12
• 230000002441 reversible effect Effects 0.000 claims description 11
• 235000013305 food Nutrition 0.000 claims description 10
• 241000894007 species Species 0.000 claims description 10
• 230000000692 anti-sense effect Effects 0.000 claims description 9
• 230000000975 bioactive effect Effects 0.000 claims description 9
• 238000012217 deletion Methods 0.000 claims description 9
• 230000037430 deletion Effects 0.000 claims description 9
• 239000000126 substance Substances 0.000 claims description 9
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 8
• 210000000987 immune system Anatomy 0.000 claims description 8
• 235000013336 milk Nutrition 0.000 claims description 8
• 239000008267 milk Substances 0.000 claims description 8
• 210000004080 milk Anatomy 0.000 claims description 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
• 230000000813 microbial effect Effects 0.000 claims description 7
• 235000015872 dietary supplement Nutrition 0.000 claims description 5
• 230000001717 pathogenic effect Effects 0.000 claims description 5
• 239000013615 primer Substances 0.000 claims description 5
• 241000124008 Mammalia Species 0.000 claims description 4
• 230000000968 intestinal effect Effects 0.000 claims description 4
• 239000002987 primer (paints) Substances 0.000 claims description 3
• 241000193830 Bacillus <bacterium> Species 0.000 claims description 2
• 230000001131 transforming effect Effects 0.000 claims description 2
• 239000000284 extract Substances 0.000 claims 3
• 239000000969 carrier Substances 0.000 claims 2
• 235000013373 food additive Nutrition 0.000 claims 2
• 239000002778 food additive Substances 0.000 claims 2
• 229960001438 immunostimulant agent Drugs 0.000 claims 2
• 239000003022 immunostimulating agent Substances 0.000 claims 2
• 230000003308 immunostimulating effect Effects 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 235000016709 nutrition Nutrition 0.000 claims 2
• 239000013589 supplement Substances 0.000 claims 2
• 241000206602 Eukaryota Species 0.000 claims 1
• 108091092724 Noncoding DNA Proteins 0.000 claims 1
• 241000204117 Sporolactobacillus Species 0.000 claims 1
• 230000007407 health benefit Effects 0.000 claims 1
• 238000002743 insertional mutagenesis Methods 0.000 claims 1
• 230000035764 nutrition Effects 0.000 claims 1
• 230000001850 reproductive effect Effects 0.000 claims 1
• 230000005070 ripening Effects 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 241000218588 Lactobacillus rhamnosus Species 0.000 abstract description 2
• 239000012620 biological material Substances 0.000 abstract description 2
• 210000001035 gastrointestinal tract Anatomy 0.000 description 180
• 210000004027 cell Anatomy 0.000 description 148
• 230000008569 process Effects 0.000 description 117
• 102000004169 proteins and genes Human genes 0.000 description 116
• 230000014509 gene expression Effects 0.000 description 114
• 235000018102 proteins Nutrition 0.000 description 105
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 104
• 239000013598 vector Substances 0.000 description 104
• 230000002503 metabolic effect Effects 0.000 description 100
• 238000010276 construction Methods 0.000 description 98
• 238000003199 nucleic acid amplification method Methods 0.000 description 98
• 238000012239 gene modification Methods 0.000 description 94
• 230000003321 amplification Effects 0.000 description 93
• 230000012010 growth Effects 0.000 description 91
• 230000005017 genetic modification Effects 0.000 description 90
• 235000013617 genetically modified food Nutrition 0.000 description 90
• 238000002703 mutagenesis Methods 0.000 description 86
• 231100000350 mutagenesis Toxicity 0.000 description 84
• 230000001093 anti-cancer Effects 0.000 description 77
• 230000006870 function Effects 0.000 description 69
• 210000002421 cell wall Anatomy 0.000 description 68
• 238000000855 fermentation Methods 0.000 description 67
• 230000004151 fermentation Effects 0.000 description 67
• 230000000845 anti-microbial effect Effects 0.000 description 60
• 230000003115 biocidal effect Effects 0.000 description 59
• 230000004957 immunoregulator effect Effects 0.000 description 59
• 108020004414 DNA Proteins 0.000 description 52
• 229910019142 PO4 Inorganic materials 0.000 description 50
• 239000010452 phosphate Substances 0.000 description 50
• 210000004102 animal cell Anatomy 0.000 description 47
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 46
• 230000015572 biosynthetic process Effects 0.000 description 45
• 230000001580 bacterial effect Effects 0.000 description 43
• 230000009467 reduction Effects 0.000 description 43
• 102000004190 Enzymes Human genes 0.000 description 42
• 108090000790 Enzymes Proteins 0.000 description 42
• 229940088598 enzyme Drugs 0.000 description 42
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 42
• 239000002253 acid Substances 0.000 description 38
• 230000008821 health effect Effects 0.000 description 38
• 230000004060 metabolic process Effects 0.000 description 38
• 229940024606 amino acid Drugs 0.000 description 37
• 235000001014 amino acid Nutrition 0.000 description 37
• 150000001413 amino acids Chemical class 0.000 description 35
• 230000027455 binding Effects 0.000 description 31
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 30
• 230000018109 developmental process Effects 0.000 description 24
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 21
• 108700026244 Open Reading Frames Proteins 0.000 description 21
• 230000006907 apoptotic process Effects 0.000 description 21
• 150000004676 glycans Chemical class 0.000 description 21
• 239000004310 lactic acid Substances 0.000 description 21
• 235000014655 lactic acid Nutrition 0.000 description 21
• 230000037361 pathway Effects 0.000 description 21
• 229920001282 polysaccharide Polymers 0.000 description 21
• 108010078791 Carrier Proteins Proteins 0.000 description 20
• 150000001720 carbohydrates Chemical class 0.000 description 20
• 235000014633 carbohydrates Nutrition 0.000 description 20
• 239000005017 polysaccharide Substances 0.000 description 20
• 235000014113 dietary fatty acids Nutrition 0.000 description 19
• 229930195729 fatty acid Natural products 0.000 description 19
• 239000000194 fatty acid Substances 0.000 description 19
• ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 18
• 238000006243 chemical reaction Methods 0.000 description 18
• -1 desaturases Proteins 0.000 description 18
• 230000035899 viability Effects 0.000 description 18
• 229930182555 Penicillin Natural products 0.000 description 17
• 150000004665 fatty acids Chemical class 0.000 description 17
• 150000002632 lipids Chemical class 0.000 description 17
• 230000035882 stress Effects 0.000 description 17
• 238000003786 synthesis reaction Methods 0.000 description 17
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 16
• 229960002685 biotin Drugs 0.000 description 16
• 235000020958 biotin Nutrition 0.000 description 16
• 239000011616 biotin Substances 0.000 description 16
• 230000037353 metabolic pathway Effects 0.000 description 16
• 229940049954 penicillin Drugs 0.000 description 16
• 230000004044 response Effects 0.000 description 15
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 14
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 14
• 238000003556 assay Methods 0.000 description 14
• 239000008101 lactose Substances 0.000 description 14
• 239000012528 membrane Substances 0.000 description 14
• 102000008186 Collagen Human genes 0.000 description 13
• 108010035532 Collagen Proteins 0.000 description 13
• 239000000427 antigen Substances 0.000 description 13
• 108091007433 antigens Proteins 0.000 description 13
• 102000036639 antigens Human genes 0.000 description 13
• 230000004048 modification Effects 0.000 description 13
• 238000012986 modification Methods 0.000 description 13
• 108010018763 Biotin carboxylase Proteins 0.000 description 12
• 229920001436 collagen Polymers 0.000 description 12
• 230000003938 response to stress Effects 0.000 description 12
• 229960005486 vaccine Drugs 0.000 description 12
• 150000007513 acids Chemical class 0.000 description 11
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 11
• 239000013604 expression vector Substances 0.000 description 11
• 241000588724 Escherichia coli Species 0.000 description 10
• 102000035195 Peptidases Human genes 0.000 description 10
• 108091005804 Peptidases Proteins 0.000 description 10
• 238000007792 addition Methods 0.000 description 10
• 230000000844 anti-bacterial effect Effects 0.000 description 10
• 235000013365 dairy product Nutrition 0.000 description 10
• 102000014914 Carrier Proteins Human genes 0.000 description 9
• 102000018697 Membrane Proteins Human genes 0.000 description 9
• 108010052285 Membrane Proteins Proteins 0.000 description 9
• 235000011180 diphosphates Nutrition 0.000 description 9
• 230000032258 transport Effects 0.000 description 9
• 238000011282 treatment Methods 0.000 description 9
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
• 102000003960 Ligases Human genes 0.000 description 8
• 108090000364 Ligases Proteins 0.000 description 8
• 230000006353 environmental stress Effects 0.000 description 8
• 230000036961 partial effect Effects 0.000 description 8
• 230000001105 regulatory effect Effects 0.000 description 8
• 230000014616 translation Effects 0.000 description 8
• 108010036824 Citrate (pro-3S)-lyase Proteins 0.000 description 7
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 7
• 230000004075 alteration Effects 0.000 description 7
• 230000037354 amino acid metabolism Effects 0.000 description 7
• 230000033228 biological regulation Effects 0.000 description 7
• 238000009833 condensation Methods 0.000 description 7
• 230000005494 condensation Effects 0.000 description 7
• 230000009089 cytolysis Effects 0.000 description 7
• 230000001965 increasing effect Effects 0.000 description 7
• 208000015181 infectious disease Diseases 0.000 description 7
• 238000003752 polymerase chain reaction Methods 0.000 description 7
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 7
• 239000000523 sample Substances 0.000 description 7
• 235000000346 sugar Nutrition 0.000 description 7
• 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 6
• 108010016626 Dipeptides Proteins 0.000 description 6
• 108010006464 Hemolysin Proteins Proteins 0.000 description 6
• 108090001030 Lipoproteins Proteins 0.000 description 6
• 102000004895 Lipoproteins Human genes 0.000 description 6
• 102000004357 Transferases Human genes 0.000 description 6
• 108090000992 Transferases Proteins 0.000 description 6
• 239000003242 anti bacterial agent Substances 0.000 description 6
• 229940088710 antibiotic agent Drugs 0.000 description 6
• 239000001177 diphosphate Substances 0.000 description 6
• 239000003228 hemolysin Substances 0.000 description 6
• 235000003642 hunger Nutrition 0.000 description 6
• 238000001727 in vivo Methods 0.000 description 6
• 230000003834 intracellular effect Effects 0.000 description 6
• 150000007523 nucleic acids Chemical class 0.000 description 6
• 239000002243 precursor Substances 0.000 description 6
• 235000019833 protease Nutrition 0.000 description 6
• 230000035939 shock Effects 0.000 description 6
• 230000037351 starvation Effects 0.000 description 6
• 230000006585 stringent response Effects 0.000 description 6
• 230000001018 virulence Effects 0.000 description 6
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 5
• HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 5
• 108010072957 Carboxyl and Carbamoyl Transferases Proteins 0.000 description 5
• 102000007132 Carboxyl and Carbamoyl Transferases Human genes 0.000 description 5
• 101710088194 Dehydrogenase Proteins 0.000 description 5
• 229930186217 Glycolipid Natural products 0.000 description 5
• 241001465754 Metazoa Species 0.000 description 5
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 5
• 230000002776 aggregation Effects 0.000 description 5
• 238000004220 aggregation Methods 0.000 description 5
• 229960003767 alanine Drugs 0.000 description 5
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 5
• 230000021523 carboxylation Effects 0.000 description 5
• 230000015556 catabolic process Effects 0.000 description 5
• 230000008859 change Effects 0.000 description 5
• 239000003795 chemical substances by application Substances 0.000 description 5
• 230000001419 dependent effect Effects 0.000 description 5
• XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 5
• 230000007717 exclusion Effects 0.000 description 5
• 238000009396 hybridization Methods 0.000 description 5
• 230000006698 induction Effects 0.000 description 5
• 230000037356 lipid metabolism Effects 0.000 description 5
• 230000004260 plant-type cell wall biogenesis Effects 0.000 description 5
• 230000002265 prevention Effects 0.000 description 5
• 150000003839 salts Chemical class 0.000 description 5
• 230000011664 signaling Effects 0.000 description 5
• 239000000758 substrate Substances 0.000 description 5
• 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 4
• 108090000084 Antiporters Proteins 0.000 description 4
• 102000003669 Antiporters Human genes 0.000 description 4
• 108700029181 Bacteria lipase activator Proteins 0.000 description 4
• 108010062877 Bacteriocins Proteins 0.000 description 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
• 108020004705 Codon Proteins 0.000 description 4
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
• 241000196324 Embryophyta Species 0.000 description 4
• 229920002444 Exopolysaccharide Polymers 0.000 description 4
• 108700023372 Glycosyltransferases Proteins 0.000 description 4
• 102000051366 Glycosyltransferases Human genes 0.000 description 4
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 4
• 206010028980 Neoplasm Diseases 0.000 description 4
• 108010013639 Peptidoglycan Proteins 0.000 description 4
• 108091000080 Phosphotransferase Proteins 0.000 description 4
• LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 4
• 102100022399 Ribosome biogenesis protein NOP53 Human genes 0.000 description 4
• 230000009471 action Effects 0.000 description 4
• 230000009286 beneficial effect Effects 0.000 description 4
• 108091008324 binding proteins Proteins 0.000 description 4
• 210000004899 c-terminal region Anatomy 0.000 description 4
• 230000023852 carbohydrate metabolic process Effects 0.000 description 4
• 235000021256 carbohydrate metabolism Nutrition 0.000 description 4
• 229910052799 carbon Inorganic materials 0.000 description 4
• 238000006473 carboxylation reaction Methods 0.000 description 4
• 230000003197 catalytic effect Effects 0.000 description 4
• 238000002507 cathodic stripping potentiometry Methods 0.000 description 4
• 210000000170 cell membrane Anatomy 0.000 description 4
• 239000003153 chemical reaction reagent Substances 0.000 description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
• 210000000349 chromosome Anatomy 0.000 description 4
• 230000002860 competitive effect Effects 0.000 description 4
• 238000006731 degradation reaction Methods 0.000 description 4
• 230000004069 differentiation Effects 0.000 description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
• 230000002708 enhancing effect Effects 0.000 description 4
• 239000012634 fragment Substances 0.000 description 4
• 230000004927 fusion Effects 0.000 description 4
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 4
• 230000008102 immune modulation Effects 0.000 description 4
• 230000036039 immunity Effects 0.000 description 4
• 230000009545 invasion Effects 0.000 description 4
• NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 description 4
• 125000004971 nitroalkyl group Chemical group 0.000 description 4
• 229920001542 oligosaccharide Polymers 0.000 description 4
• 150000002482 oligosaccharides Chemical class 0.000 description 4
• 230000008520 organization Effects 0.000 description 4
• 244000052769 pathogen Species 0.000 description 4
• 230000007918 pathogenicity Effects 0.000 description 4
• 102000020233 phosphotransferase Human genes 0.000 description 4
• 230000001681 protective effect Effects 0.000 description 4
• 230000003946 protein process Effects 0.000 description 4
• 150000003212 purines Chemical class 0.000 description 4
• 238000012163 sequencing technique Methods 0.000 description 4
• 235000021391 short chain fatty acids Nutrition 0.000 description 4
• 150000004666 short chain fatty acids Chemical class 0.000 description 4
• 238000012546 transfer Methods 0.000 description 4
• UWOCFOFVIBZJGH-UHFFFAOYSA-N 2,3-dihydrodipicolinic acid Chemical compound OC(=O)C1CC=CC(C(O)=O)=N1 UWOCFOFVIBZJGH-UHFFFAOYSA-N 0.000 description 3
• WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
• 108010000700 Acetolactate synthase Proteins 0.000 description 3
• 102100039164 Acetyl-CoA carboxylase 1 Human genes 0.000 description 3
• 108700023418 Amidases Proteins 0.000 description 3
• 102000004031 Carboxy-Lyases Human genes 0.000 description 3
• 108090000489 Carboxy-Lyases Proteins 0.000 description 3
• 102000006303 Chaperonin 60 Human genes 0.000 description 3
• 108010058432 Chaperonin 60 Proteins 0.000 description 3
• RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 3
• KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 description 3
• 230000004543 DNA replication Effects 0.000 description 3
• 108090001081 Dipeptidases Proteins 0.000 description 3
• 102000004860 Dipeptidases Human genes 0.000 description 3
• 102000018389 Exopeptidases Human genes 0.000 description 3
• 108010091443 Exopeptidases Proteins 0.000 description 3
• 102100035111 Farnesyl pyrophosphate synthase Human genes 0.000 description 3
• 241000238631 Hexapoda Species 0.000 description 3
• 108010072039 Histidine kinase Proteins 0.000 description 3
• 102000004195 Isomerases Human genes 0.000 description 3
• 108090000769 Isomerases Proteins 0.000 description 3
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 3
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 3
• 239000004472 Lysine Substances 0.000 description 3
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
• 240000002129 Malva sylvestris Species 0.000 description 3
• 235000006770 Malva sylvestris Nutrition 0.000 description 3
• 102000003939 Membrane transport proteins Human genes 0.000 description 3
• 108090000301 Membrane transport proteins Proteins 0.000 description 3
• MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 3
• 208000012868 Overgrowth Diseases 0.000 description 3
• 239000004365 Protease Substances 0.000 description 3
• KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 3
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
• 108010022999 Serine Proteases Proteins 0.000 description 3
• 102000012479 Serine Proteases Human genes 0.000 description 3
• 101710135785 Subtilisin-like protease Proteins 0.000 description 3
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 3
• 230000002411 adverse Effects 0.000 description 3
• 102000005922 amidase Human genes 0.000 description 3
• 238000004458 analytical method Methods 0.000 description 3
• 238000004873 anchoring Methods 0.000 description 3
• 239000003782 beta lactam antibiotic agent Substances 0.000 description 3
• 108010005774 beta-Galactosidase Proteins 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 201000011510 cancer Diseases 0.000 description 3
• 230000000711 cancerogenic effect Effects 0.000 description 3
• 231100000315 carcinogenic Toxicity 0.000 description 3
• 230000024245 cell differentiation Effects 0.000 description 3
• 239000007795 chemical reaction product Substances 0.000 description 3
• 229960001231 choline Drugs 0.000 description 3
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 3
• 238000003776 cleavage reaction Methods 0.000 description 3
• RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 3
• 239000005515 coenzyme Substances 0.000 description 3
• 239000005516 coenzyme A Substances 0.000 description 3
• 229940093530 coenzyme a Drugs 0.000 description 3
• 238000004132 cross linking Methods 0.000 description 3
• 230000003247 decreasing effect Effects 0.000 description 3
• KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 3
• 208000035475 disorder Diseases 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• 230000007613 environmental effect Effects 0.000 description 3
• 102000010660 flotillin Human genes 0.000 description 3
• 108060000864 flotillin Proteins 0.000 description 3
• 235000021588 free fatty acids Nutrition 0.000 description 3
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
• 108700014210 glycosyltransferase activity proteins Proteins 0.000 description 3
• 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 3
• 230000007062 hydrolysis Effects 0.000 description 3
• 238000006460 hydrolysis reaction Methods 0.000 description 3
• 230000005764 inhibitory process Effects 0.000 description 3
• 229960000310 isoleucine Drugs 0.000 description 3
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 3
• 235000010335 lysozyme Nutrition 0.000 description 3
• 101150074096 mraY gene Proteins 0.000 description 3
• 102000039446 nucleic acids Human genes 0.000 description 3
• 108020004707 nucleic acids Proteins 0.000 description 3
• 150000007524 organic acids Chemical class 0.000 description 3
• 235000005985 organic acids Nutrition 0.000 description 3
• KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 3
• 238000007254 oxidation reaction Methods 0.000 description 3
• 230000008506 pathogenesis Effects 0.000 description 3
• LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 3
• 238000006116 polymerization reaction Methods 0.000 description 3
• 230000002797 proteolythic effect Effects 0.000 description 3
• 108020003175 receptors Proteins 0.000 description 3
• 230000007017 scission Effects 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 229930185156 spinosyn Natural products 0.000 description 3
• 239000007858 starting material Substances 0.000 description 3
• 231100000331 toxic Toxicity 0.000 description 3
• 230000002588 toxic effect Effects 0.000 description 3
• 108700012359 toxins Proteins 0.000 description 3
• 230000005945 translocation Effects 0.000 description 3
• 239000004474 valine Substances 0.000 description 3
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
• KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 description 2
• 108010063198 6-phospho-beta-galactosidase Proteins 0.000 description 2
• 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 description 2
• 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 description 2
• 241000023308 Acca Species 0.000 description 2
• IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
• 108010021809 Alcohol dehydrogenase Proteins 0.000 description 2
• 108090000531 Amidohydrolases Proteins 0.000 description 2
• 102000004092 Amidohydrolases Human genes 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 208000023275 Autoimmune disease Diseases 0.000 description 2
• 235000014469 Bacillus subtilis Nutrition 0.000 description 2
• 102100026189 Beta-galactosidase Human genes 0.000 description 2
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
• 108010006303 Carboxypeptidases Proteins 0.000 description 2
• 102000005367 Carboxypeptidases Human genes 0.000 description 2
• 102000011632 Caseins Human genes 0.000 description 2
• 108010076119 Caseins Proteins 0.000 description 2
• 102100035882 Catalase Human genes 0.000 description 2
• 108010053835 Catalase Proteins 0.000 description 2
• 108050001186 Chaperonin Cpn60 Proteins 0.000 description 2
• 102000052603 Chaperonins Human genes 0.000 description 2
• ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
• 101710088599 Cold shock-like protein CspLB Proteins 0.000 description 2
• 206010009944 Colon cancer Diseases 0.000 description 2
• 102000016918 Complement C3 Human genes 0.000 description 2
• 108010028780 Complement C3 Proteins 0.000 description 2
• 206010010774 Constipation Diseases 0.000 description 2
• DEFJQIDDEAULHB-QWWZWVQMSA-N D-alanyl-D-alanine Chemical compound C[C@@H]([NH3+])C(=O)N[C@H](C)C([O-])=O DEFJQIDDEAULHB-QWWZWVQMSA-N 0.000 description 2
• WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 description 2
• MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 2
• QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 2
• 206010012735 Diarrhoea Diseases 0.000 description 2
• 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 description 2
• 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 description 2
• 241000448280 Elates Species 0.000 description 2
• 239000004386 Erythritol Substances 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• 108010067306 Fibronectins Proteins 0.000 description 2
• 102000016359 Fibronectins Human genes 0.000 description 2
• 241000192125 Firmicutes Species 0.000 description 2
• 108010026318 Geranyltranstransferase Proteins 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• 108010055629 Glucosyltransferases Proteins 0.000 description 2
• 102000000340 Glucosyltransferases Human genes 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
• 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 2
• 102000004157 Hydrolases Human genes 0.000 description 2
• 108090000604 Hydrolases Proteins 0.000 description 2
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
• 102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
• 108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
• 241000186781 Listeria Species 0.000 description 2
• 102000004317 Lyases Human genes 0.000 description 2
• 108090000856 Lyases Proteins 0.000 description 2
• LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 description 2
• 102100027329 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Human genes 0.000 description 2
• 108010090665 Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase Proteins 0.000 description 2
• 108010014251 Muramidase Proteins 0.000 description 2
• 102000016943 Muramidase Human genes 0.000 description 2
• DEFJQIDDEAULHB-UHFFFAOYSA-N N-D-alanyl-D-alanine Natural products CC(N)C(=O)NC(C)C(O)=O DEFJQIDDEAULHB-UHFFFAOYSA-N 0.000 description 2
• 102100030397 N-acetylmuramoyl-L-alanine amidase Human genes 0.000 description 2
• 101710202686 Penicillin-sensitive transpeptidase Proteins 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 101710104378 Putative malate oxidoreductase [NAD] Proteins 0.000 description 2
• CVBNMWXECPZOLM-UHFFFAOYSA-N Rhamnetin Natural products COc1cc(O)c2C(=O)C(=C(Oc2c1)c3ccc(O)c(O)c3O)O CVBNMWXECPZOLM-UHFFFAOYSA-N 0.000 description 2
• 241000191940 Staphylococcus Species 0.000 description 2
• 230000005867 T cell response Effects 0.000 description 2
• 108020004566 Transfer RNA Proteins 0.000 description 2
• 108010073429 Type V Secretion Systems Proteins 0.000 description 2
• DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 2
• 101150008263 accD gene Proteins 0.000 description 2
• 125000002252 acyl group Chemical group 0.000 description 2
• 101150014383 adhE gene Proteins 0.000 description 2
• 230000000240 adjuvant effect Effects 0.000 description 2
• 235000004279 alanine Nutrition 0.000 description 2
• 108010056243 alanylalanine Proteins 0.000 description 2
• 150000001298 alcohols Chemical class 0.000 description 2
• LSJLEXWXRKTZAJ-YUIIPXGZSA-N all-trans-heptaprenyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O LSJLEXWXRKTZAJ-YUIIPXGZSA-N 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• 229940067621 aminobutyrate Drugs 0.000 description 2
• 230000003276 anti-hypertensive effect Effects 0.000 description 2
• 230000003078 antioxidant effect Effects 0.000 description 2
• 239000003833 bile salt Substances 0.000 description 2
• 230000004071 biological effect Effects 0.000 description 2
• 239000012472 biological sample Substances 0.000 description 2
• 239000003876 biosurfactant Substances 0.000 description 2
• 108010036467 butanediol dehydrogenase Proteins 0.000 description 2
• 230000025938 carbohydrate utilization Effects 0.000 description 2
• 210000000845 cartilage Anatomy 0.000 description 2
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
• 235000021240 caseins Nutrition 0.000 description 2
• 150000001768 cations Chemical class 0.000 description 2
• 210000004323 caveolae Anatomy 0.000 description 2
• 230000021164 cell adhesion Effects 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 235000012000 cholesterol Nutrition 0.000 description 2
• 235000017471 coenzyme Q10 Nutrition 0.000 description 2
• ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
• 210000001072 colon Anatomy 0.000 description 2
• 208000029742 colonic neoplasm Diseases 0.000 description 2
• 230000001276 controlling effect Effects 0.000 description 2
• 101150059761 ctrA gene Proteins 0.000 description 2
• 238000006356 dehydrogenation reaction Methods 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 238000001784 detoxification Methods 0.000 description 2
• 238000002405 diagnostic procedure Methods 0.000 description 2
• XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 2
• 239000002158 endotoxin Substances 0.000 description 2
• 230000037149 energy metabolism Effects 0.000 description 2
• 244000000021 enteric pathogen Species 0.000 description 2
• 229940009714 erythritol Drugs 0.000 description 2
• 210000003527 eukaryotic cell Anatomy 0.000 description 2
• 230000001747 exhibiting effect Effects 0.000 description 2
• 108091023030 exopolyphosphatase Proteins 0.000 description 2
• 235000021001 fermented dairy product Nutrition 0.000 description 2
• 101150032444 gadC gene Proteins 0.000 description 2
• 238000003209 gene knockout Methods 0.000 description 2
• 101150089678 glnQ gene Proteins 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 230000002949 hemolytic effect Effects 0.000 description 2
• 208000007386 hepatic encephalopathy Diseases 0.000 description 2
• 230000003301 hydrolyzing effect Effects 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 230000036737 immune function Effects 0.000 description 2
• 230000002757 inflammatory effect Effects 0.000 description 2
• 230000000977 initiatory effect Effects 0.000 description 2
• 229910052816 inorganic phosphate Inorganic materials 0.000 description 2
• 230000003993 interaction Effects 0.000 description 2
• 230000006525 intracellular process Effects 0.000 description 2
• 150000002500 ions Chemical class 0.000 description 2
• 229910052742 iron Inorganic materials 0.000 description 2
• 208000002551 irritable bowel syndrome Diseases 0.000 description 2
• 150000002596 lactones Chemical class 0.000 description 2
• 229940049918 linoleate Drugs 0.000 description 2
• 229920006008 lipopolysaccharide Polymers 0.000 description 2
• 239000006166 lysate Substances 0.000 description 2
• 239000003120 macrolide antibiotic agent Substances 0.000 description 2
• 229940049920 malate Drugs 0.000 description 2
• LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 description 2
• 238000013507 mapping Methods 0.000 description 2
• 108020004999 messenger RNA Proteins 0.000 description 2
• 238000012775 microarray technology Methods 0.000 description 2
• 150000002772 monosaccharides Chemical class 0.000 description 2
• 230000004899 motility Effects 0.000 description 2
• 230000004677 mucosal permeability Effects 0.000 description 2
• 230000001590 oxidative effect Effects 0.000 description 2
• 230000036542 oxidative stress Effects 0.000 description 2
• 230000002688 persistence Effects 0.000 description 2
• DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 description 2
• 210000001236 prokaryotic cell Anatomy 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• 235000019419 proteases Nutrition 0.000 description 2
• 210000004270 pstb Anatomy 0.000 description 2
• 101150045242 ptsH gene Proteins 0.000 description 2
• 101150019467 purE gene Proteins 0.000 description 2
• 101150106935 purR gene Proteins 0.000 description 2
• 101150054232 pyrG gene Proteins 0.000 description 2
• 239000002516 radical scavenger Substances 0.000 description 2
• 101150007867 rbfox2 gene Proteins 0.000 description 2
• 102000005962 receptors Human genes 0.000 description 2
• NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 230000007363 regulatory process Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 230000002000 scavenging effect Effects 0.000 description 2
• 150000008163 sugars Chemical class 0.000 description 2
• 239000002344 surface layer Substances 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 238000013519 translation Methods 0.000 description 2
• LABSPYBHMPDTEL-JGZVXCDNSA-N trehalose-6-phosphate Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@@H]1O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](COP(O)(O)=O)O1 LABSPYBHMPDTEL-JGZVXCDNSA-N 0.000 description 2
• 108010020589 trehalose-6-phosphate synthase Proteins 0.000 description 2
• 229940035936 ubiquinone Drugs 0.000 description 2
• 238000002255 vaccination Methods 0.000 description 2
• 239000000304 virulence factor Substances 0.000 description 2
• 230000007923 virulence factor Effects 0.000 description 2
• 235000013343 vitamin Nutrition 0.000 description 2
• 239000011782 vitamin Substances 0.000 description 2
• 229940088594 vitamin Drugs 0.000 description 2
• 229930003231 vitamin Natural products 0.000 description 2
• 150000003722 vitamin derivatives Chemical class 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 239000002132 β-lactam antibiotic Substances 0.000 description 2
• 229940124586 β-lactam antibiotics Drugs 0.000 description 2
• 150000003952 β-lactams Chemical class 0.000 description 2
• FSCYHDCTHRVSKN-DJNGBRKISA-N (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/COP(O)(=O)OP(O)(O)=O FSCYHDCTHRVSKN-DJNGBRKISA-N 0.000 description 1
• BWNGEDLBTNTBMD-ZETCQYMHSA-N (2s)-1,2-dimethylpyrrolidine-2-carboxylic acid Chemical compound CN1CCC[C@@]1(C)C(O)=O BWNGEDLBTNTBMD-ZETCQYMHSA-N 0.000 description 1
• DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 description 1
• PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
• USZZLTVYRPLBMB-UHFFFAOYSA-N 1,3-dihydroxynaphthalene-2-carboxylic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=C(O)C=C21 USZZLTVYRPLBMB-UHFFFAOYSA-N 0.000 description 1
• VOJUXHHACRXLTD-UHFFFAOYSA-M 1,4-dihydroxy-2-naphthoate Chemical compound C1=CC=C2C(O)=CC(C([O-])=O)=C(O)C2=C1 VOJUXHHACRXLTD-UHFFFAOYSA-M 0.000 description 1
• UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
• GMKMEZVLHJARHF-UHFFFAOYSA-N 2,6-diaminopimelic acid Chemical compound OC(=O)C(N)CCCC(N)C(O)=O GMKMEZVLHJARHF-UHFFFAOYSA-N 0.000 description 1
• VUQLHQFKACOHNZ-UHFFFAOYSA-N 2-Aceto-2-hydroxybutanoate Chemical compound CCC(O)(C(C)=O)C(O)=O VUQLHQFKACOHNZ-UHFFFAOYSA-N 0.000 description 1
• XWJBVGZSIAZDKJ-FXQIFTODSA-N 2-[3-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]propyl]propanedioic acid Chemical compound N1C(=O)N[C@@H]2[C@H](CCCC(C(=O)O)C(O)=O)SC[C@@H]21 XWJBVGZSIAZDKJ-FXQIFTODSA-N 0.000 description 1
• IAJOBQBIJHVGMQ-UHFFFAOYSA-N 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid Chemical compound CP(O)(=O)CCC(N)C(O)=O IAJOBQBIJHVGMQ-UHFFFAOYSA-N 0.000 description 1
• 108010065780 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Proteins 0.000 description 1
• NMYLSLKWQQWWSC-GWTDSMLYSA-N 2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;phosphoric acid Chemical class OP(O)(O)=O.C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NMYLSLKWQQWWSC-GWTDSMLYSA-N 0.000 description 1
• GDUBPWSFXUAETN-AENDIINCSA-N 2-demethylmenaquinone-8 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=CC(=O)C2=C1 GDUBPWSFXUAETN-AENDIINCSA-N 0.000 description 1
• VWFJDQUYCIWHTN-YFVJMOTDSA-N 2-trans,6-trans-farnesyl diphosphate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO[P@](O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-YFVJMOTDSA-N 0.000 description 1
• LJQLQCAXBUHEAZ-UWTATZPHSA-N 3-phospho-D-glyceroyl dihydrogen phosphate Chemical compound OP(=O)(O)OC[C@@H](O)C(=O)OP(O)(O)=O LJQLQCAXBUHEAZ-UWTATZPHSA-N 0.000 description 1
• QRZMXADUXZADTF-UHFFFAOYSA-N 4-aminoimidazole Chemical compound NC1=CNC=N1 QRZMXADUXZADTF-UHFFFAOYSA-N 0.000 description 1
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
• OYHQOLUKZRVURQ-HZJYTTRNSA-M 9-cis,12-cis-Octadecadienoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O OYHQOLUKZRVURQ-HZJYTTRNSA-M 0.000 description 1
• 239000005541 ACE inhibitor Substances 0.000 description 1
• 206010000050 Abdominal adhesions Diseases 0.000 description 1
• 108010002945 Acetoin dehydrogenase Proteins 0.000 description 1
• 101710146995 Acyl carrier protein Proteins 0.000 description 1
• 101710174135 Acyl-coenzyme A dehydrogenase Proteins 0.000 description 1
• 229930195730 Aflatoxin Natural products 0.000 description 1
• XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 1
• XZWXFWBHYRFLEF-FSPLSTOPSA-N Ala-His Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 XZWXFWBHYRFLEF-FSPLSTOPSA-N 0.000 description 1
• 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
• 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 1
• 102000005369 Aldehyde Dehydrogenase Human genes 0.000 description 1
• 108090000915 Aminopeptidases Proteins 0.000 description 1
• 102000004400 Aminopeptidases Human genes 0.000 description 1
• 108020005098 Anticodon Proteins 0.000 description 1
• 108010053481 Antifreeze Proteins Proteins 0.000 description 1
• 101100062433 Arabidopsis thaliana DHDPS1 gene Proteins 0.000 description 1
• 241000203069 Archaea Species 0.000 description 1
• 241000370685 Arge Species 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 208000035404 Autolysis Diseases 0.000 description 1
• NTTIDCCSYIDANP-UHFFFAOYSA-N BCCP Chemical compound BCCP NTTIDCCSYIDANP-UHFFFAOYSA-N 0.000 description 1
• 244000063299 Bacillus subtilis Species 0.000 description 1
• 101000588395 Bacillus subtilis (strain 168) Beta-hexosaminidase Proteins 0.000 description 1
• 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
• 101001074429 Bacillus subtilis (strain 168) Polyketide biosynthesis acyltransferase homolog PksD Proteins 0.000 description 1
• 101100378010 Bacillus subtilis (strain 168) accC1 gene Proteins 0.000 description 1
• 101100322122 Bacillus subtilis (strain 168) accC2 gene Proteins 0.000 description 1
• 101000936617 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) Polyketide biosynthesis acyltransferase homolog BaeD Proteins 0.000 description 1
• 108700003860 Bacterial Genes Proteins 0.000 description 1
• 101710125089 Bindin Proteins 0.000 description 1
• 101710201279 Biotin carboxyl carrier protein Proteins 0.000 description 1
• 101710180532 Biotin carboxyl carrier protein of acetyl-CoA carboxylase Proteins 0.000 description 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
• QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
• 108010087806 Carnosine Proteins 0.000 description 1
• 206010057248 Cell death Diseases 0.000 description 1
• 229930186147 Cephalosporin Natural products 0.000 description 1
• 241000511343 Chondrostoma nasus Species 0.000 description 1
• 241001112695 Clostridiales Species 0.000 description 1
• 108010049152 Cold Shock Proteins and Peptides Proteins 0.000 description 1
• 108010073254 Colicins Proteins 0.000 description 1
• MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
• 101100138542 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) phbH gene Proteins 0.000 description 1
• LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 1
• UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• 108010071840 Cytosol nonspecific dipeptidase Proteins 0.000 description 1
• NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 1
• 229930195713 D-glutamate Natural products 0.000 description 1
• NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
• 108010014312 DNA-Cytosine Methylases Proteins 0.000 description 1
• 102000016923 DNA-Cytosine Methylases Human genes 0.000 description 1
• 230000004568 DNA-binding Effects 0.000 description 1
• 241000361255 Diogenes Species 0.000 description 1
• 102000016680 Dioxygenases Human genes 0.000 description 1
• 108010028143 Dioxygenases Proteins 0.000 description 1
• 108700040484 Diphosphomevalonate decarboxylases Proteins 0.000 description 1
• 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 1
• 108010059378 Endopeptidases Proteins 0.000 description 1
• 102000005593 Endopeptidases Human genes 0.000 description 1
• 241000305071 Enterobacterales Species 0.000 description 1
• 101710146739 Enterotoxin Proteins 0.000 description 1
• 101710091045 Envelope protein Proteins 0.000 description 1
• UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
• 241000588722 Escherichia Species 0.000 description 1
• 101100397294 Escherichia coli (strain K12) ispE gene Proteins 0.000 description 1
• 108090000371 Esterases Proteins 0.000 description 1
• VWFJDQUYCIWHTN-UHFFFAOYSA-N Farnesyl pyrophosphate Natural products CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O VWFJDQUYCIWHTN-UHFFFAOYSA-N 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 239000004606 Fillers/Extenders Substances 0.000 description 1
• 108010057573 Flavoproteins Proteins 0.000 description 1
• 102000003983 Flavoproteins Human genes 0.000 description 1
• 102100023513 Flotillin-2 Human genes 0.000 description 1
• 101710164820 Flotillin-2 Proteins 0.000 description 1
• CEAGUSGLAUVBEQ-UHFFFAOYSA-N Forosamine Natural products CC1CC(N(C)C)CC(O)O1 CEAGUSGLAUVBEQ-UHFFFAOYSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 108050001280 GABA permeases Proteins 0.000 description 1
• 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 description 1
• VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 1
• 108010060309 Glucuronidase Proteins 0.000 description 1
• 102000053187 Glucuronidase Human genes 0.000 description 1
• 239000005561 Glufosinate Substances 0.000 description 1
• 102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 108010015899 Glycopeptides Proteins 0.000 description 1
• 102000002068 Glycopeptides Human genes 0.000 description 1
• 229920002683 Glycosaminoglycan Polymers 0.000 description 1
• 102000005744 Glycoside Hydrolases Human genes 0.000 description 1
• 108010031186 Glycoside Hydrolases Proteins 0.000 description 1
• 108091069596 HPr family Proteins 0.000 description 1
• 101100520453 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) mvaD gene Proteins 0.000 description 1
• 206010019375 Helicobacter infections Diseases 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000963424 Homo sapiens Acetyl-CoA carboxylase 1 Proteins 0.000 description 1
• 101000938391 Homo sapiens Transmembrane protein Proteins 0.000 description 1
• 102000003918 Hyaluronan Synthases Human genes 0.000 description 1
• 108090000320 Hyaluronan Synthases Proteins 0.000 description 1
• 206010020751 Hypersensitivity Diseases 0.000 description 1
• 208000019637 Infantile Diarrhea Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 108010044467 Isoenzymes Proteins 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• 239000004201 L-cysteine Substances 0.000 description 1
• 235000013878 L-cysteine Nutrition 0.000 description 1
• LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• CMUNUTVVOOHQPW-LURJTMIESA-N L-proline betaine Chemical compound C[N+]1(C)CCC[C@H]1C([O-])=O CMUNUTVVOOHQPW-LURJTMIESA-N 0.000 description 1
• 108010059881 Lactase Proteins 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• 101100463438 Lactobacillus delbrueckii subsp. lactis pepV gene Proteins 0.000 description 1
• 241000186604 Lactobacillus reuteri Species 0.000 description 1
• 241000194036 Lactococcus Species 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 241000283986 Lepus Species 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 108090001060 Lipase Proteins 0.000 description 1
• 102000004882 Lipase Human genes 0.000 description 1
• 239000004367 Lipase Substances 0.000 description 1
• 101100244190 Mannheimia haemolytica plpB gene Proteins 0.000 description 1
• XRYVAQQLDYTHCL-UHFFFAOYSA-N Marini Chemical compound O1C=2C(CC(CC=C(C)C)C(C)=C)=C(O)C=C(O)C=2C(=O)CC1C1=CC=C(O)C=C1O XRYVAQQLDYTHCL-UHFFFAOYSA-N 0.000 description 1
• 108060004795 Methyltransferase Proteins 0.000 description 1
• 108010006519 Molecular Chaperones Proteins 0.000 description 1
• 102000005431 Molecular Chaperones Human genes 0.000 description 1
• JRLGPAXAGHMNOL-LURJTMIESA-N N(2)-acetyl-L-ornithine Chemical compound CC(=O)N[C@H](C([O-])=O)CCC[NH3+] JRLGPAXAGHMNOL-LURJTMIESA-N 0.000 description 1
• 108010046068 N-Acetyllactosamine Synthase Proteins 0.000 description 1
• VZVQOWUYAAWBCP-LURJTMIESA-N N-acetyl-L-phosphinothricin Chemical compound CC(=O)N[C@H](C(O)=O)CCP(C)(O)=O VZVQOWUYAAWBCP-LURJTMIESA-N 0.000 description 1
• ICMUIFDBEVJCQA-GFBFODDVSA-N N-acetyl-alpha-D-muramoyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@@H]1NC(C)=O ICMUIFDBEVJCQA-GFBFODDVSA-N 0.000 description 1
• 101710097941 N-acetylmuramoyl-L-alanine amidase CwlA Proteins 0.000 description 1
• CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 1
• 102100022365 NAD(P)H dehydrogenase [quinone] 1 Human genes 0.000 description 1
• 101100377539 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) ncd-2 gene Proteins 0.000 description 1
• IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
• 102000004459 Nitroreductase Human genes 0.000 description 1
• ZZQZAIFZKAELJI-MWMWYHAWSA-N OC(COC(/C(\O)=C/C=C/C(O)=O)=O)=O Chemical compound OC(COC(/C(\O)=C/C=C/C(O)=O)=O)=O ZZQZAIFZKAELJI-MWMWYHAWSA-N 0.000 description 1
• 108010026867 Oligo-1,6-Glucosidase Proteins 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 108010038807 Oligopeptides Proteins 0.000 description 1
• 102000015636 Oligopeptides Human genes 0.000 description 1
• 102000004316 Oxidoreductases Human genes 0.000 description 1
• 108090000854 Oxidoreductases Proteins 0.000 description 1
• 101150075130 PNOC gene Proteins 0.000 description 1
• 241000606860 Pasteurella Species 0.000 description 1
• 108010068563 PepT tripeptidase Proteins 0.000 description 1
• 108010064785 Phospholipases Proteins 0.000 description 1
• 102000015439 Phospholipases Human genes 0.000 description 1
• 102100027330 Phosphoribosylaminoimidazole carboxylase Human genes 0.000 description 1
• 101710114209 Photosystem I iron-sulfur center Proteins 0.000 description 1
• 229920000388 Polyphosphate Polymers 0.000 description 1
• 101710188315 Protein X Proteins 0.000 description 1
• 108010011939 Pyruvate Decarboxylase Proteins 0.000 description 1
• 101710181816 Pyruvate-formate-lyase deactivase Proteins 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 101100000272 Rhizobium meliloti (strain 1021) acsA2 gene Proteins 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• 206010067470 Rotavirus infection Diseases 0.000 description 1
• 108010082913 S-layer proteins Proteins 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• 241000607768 Shigella Species 0.000 description 1
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 101100095302 Streptococcus gordonii secA1 gene Proteins 0.000 description 1
• 244000057717 Streptococcus lactis Species 0.000 description 1
• 235000014897 Streptococcus lactis Nutrition 0.000 description 1
• 108010034396 Streptogramins Proteins 0.000 description 1
• 102100027918 Sucrase-isomaltase, intestinal Human genes 0.000 description 1
• 239000005864 Sulphur Substances 0.000 description 1
• 102000003673 Symporters Human genes 0.000 description 1
• 108090000088 Symporters Proteins 0.000 description 1
• 210000004241 Th2 cell Anatomy 0.000 description 1
• 102000003929 Transaminases Human genes 0.000 description 1
• 108090000340 Transaminases Proteins 0.000 description 1
• 108090000361 Transferred entry: 3.4.13.18 and 3.4.13.20 Proteins 0.000 description 1
• 240000001085 Trapa natans Species 0.000 description 1
• 101000980463 Treponema pallidum (strain Nichols) Chaperonin GroEL Proteins 0.000 description 1
• 108010039203 Tripeptidyl-Peptidase 1 Proteins 0.000 description 1
• 102100034197 Tripeptidyl-peptidase 1 Human genes 0.000 description 1
• LFTYTUAZOPRMMI-CFRASDGPSA-N UDP-N-acetyl-alpha-D-glucosamine Chemical compound O1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](NC(=O)C)[C@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-CFRASDGPSA-N 0.000 description 1
• 108010059029 UDP-N-acetylglucosamine transferase Proteins 0.000 description 1
• LFTYTUAZOPRMMI-UHFFFAOYSA-N UNPD164450 Natural products O1C(CO)C(O)C(O)C(NC(=O)C)C1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-UHFFFAOYSA-N 0.000 description 1
• 108010046334 Urease Proteins 0.000 description 1
• 102220594896 Vasopressin-neurophysin 2-copeptin_M20A_mutation Human genes 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 description 1
• 241000607479 Yersinia pestis Species 0.000 description 1
• 101150013885 accB gene Proteins 0.000 description 1
• 101150070497 accC gene Proteins 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• 108010084631 acetolactate decarboxylase Proteins 0.000 description 1
• 230000000397 acetylating effect Effects 0.000 description 1
• 101150116076 acsA gene Proteins 0.000 description 1
• 101150081706 acsAB gene Proteins 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 230000009056 active transport Effects 0.000 description 1
• 230000006978 adaptation Effects 0.000 description 1
• 230000003044 adaptive effect Effects 0.000 description 1
• 229960005305 adenosine Drugs 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 239000005409 aflatoxin Substances 0.000 description 1
• 108010070944 alanylhistidine Proteins 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 230000002009 allergenic effect Effects 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 230000007815 allergy Effects 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
• 235000019728 animal nutrition Nutrition 0.000 description 1
• 230000002924 anti-infective effect Effects 0.000 description 1
• 230000002790 anti-mutagenic effect Effects 0.000 description 1
• 230000002337 anti-port Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 230000030741 antigen processing and presentation Effects 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 101150105638 argE gene Proteins 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• JGGLZQUGOKVDGS-VYTIMWRQSA-N aspartate semialdehyde Chemical compound O[C@@H]1[C@@H](NC(=O)C)CO[C@H](CO)[C@H]1O[C@@H]1[C@@H](NC(C)=O)[C@H](O)[C@H](O[C@@H]2[C@H]([C@@H](O[C@@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](CO)O3)O[C@@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](CO)O3)O[C@@H]3[C@H]([C@H](O)[C@@H](O)[C@H](CO)O3)O)[C@@H](O)[C@H](CO[C@@H]3[C@H]([C@H](O[C@@H]4[C@H]([C@H](O)[C@@H](O)[C@H](CO)O4)O)[C@@H](O)[C@H](CO)O3)O)O2)O)[C@H](CO)O1 JGGLZQUGOKVDGS-VYTIMWRQSA-N 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 230000002358 autolytic effect Effects 0.000 description 1
• 229960004099 azithromycin Drugs 0.000 description 1
• MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
• 108010066657 azoreductase Proteins 0.000 description 1
• 244000052616 bacterial pathogen Species 0.000 description 1
• DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 229960003237 betaine Drugs 0.000 description 1
• 125000002619 bicyclic group Chemical group 0.000 description 1
• 230000001588 bifunctional effect Effects 0.000 description 1
• 229940093761 bile salts Drugs 0.000 description 1
• 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
• 235000019636 bitter flavor Nutrition 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
• 231100000357 carcinogen Toxicity 0.000 description 1
• 239000003183 carcinogenic agent Substances 0.000 description 1
• 229960004203 carnitine Drugs 0.000 description 1
• 229940044199 carnosine Drugs 0.000 description 1
• CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• 229940021722 caseins Drugs 0.000 description 1
• 230000003915 cell function Effects 0.000 description 1
• 230000003833 cell viability Effects 0.000 description 1
• 210000003850 cellular structure Anatomy 0.000 description 1
• 229940124587 cephalosporin Drugs 0.000 description 1
• 150000001780 cephalosporins Chemical class 0.000 description 1
• 101150090177 cheY gene Proteins 0.000 description 1
• 230000003399 chemotactic effect Effects 0.000 description 1
• 230000035605 chemotaxis Effects 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 102000021124 collagen binding proteins Human genes 0.000 description 1
• 108091011142 collagen binding proteins Proteins 0.000 description 1
• 230000000112 colonic effect Effects 0.000 description 1
• 238000010960 commercial process Methods 0.000 description 1
• 238000004891 communication Methods 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 230000000536 complexating effect Effects 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 101150049887 cspB gene Proteins 0.000 description 1
• 101150041068 cspJ gene Proteins 0.000 description 1
• 101150010904 cspLB gene Proteins 0.000 description 1
• 238000005888 cyclopropanation reaction Methods 0.000 description 1
• 229960003067 cystine Drugs 0.000 description 1
• UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
• 229960000975 daunorubicin Drugs 0.000 description 1
• 238000005034 decoration Methods 0.000 description 1
• 230000007423 decrease Effects 0.000 description 1
• 239000007857 degradation product Substances 0.000 description 1
• 230000018044 dehydration Effects 0.000 description 1
• 238000006297 dehydration reaction Methods 0.000 description 1
• 150000008266 deoxy sugars Chemical class 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 108010089355 dihydroneopterin aldolase Proteins 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 230000009429 distress Effects 0.000 description 1
• 229960004679 doxorubicin Drugs 0.000 description 1
• 239000003596 drug target Substances 0.000 description 1
• 108010060371 endo-N-acetylmuramidase Proteins 0.000 description 1
• 206010014665 endocarditis Diseases 0.000 description 1
• 229940066758 endopeptidases Drugs 0.000 description 1
• 239000000147 enterotoxin Substances 0.000 description 1
• 231100000655 enterotoxin Toxicity 0.000 description 1
• 230000007515 enzymatic degradation Effects 0.000 description 1
• 230000006862 enzymatic digestion Effects 0.000 description 1
• 230000002255 enzymatic effect Effects 0.000 description 1
• UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
• 235000019414 erythritol Nutrition 0.000 description 1
• 229960003276 erythromycin Drugs 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 239000002360 explosive Substances 0.000 description 1
• 230000006529 extracellular process Effects 0.000 description 1
• 230000008622 extracellular signaling Effects 0.000 description 1
• 101150026389 fabF gene Proteins 0.000 description 1
• 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 230000004133 fatty acid degradation Effects 0.000 description 1
• 210000003608 fece Anatomy 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 238000005189 flocculation Methods 0.000 description 1
• 230000016615 flocculation Effects 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 229940014144 folate Drugs 0.000 description 1
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
• 235000019152 folic acid Nutrition 0.000 description 1
• 239000011724 folic acid Substances 0.000 description 1
• 235000019256 formaldehyde Nutrition 0.000 description 1
• 108010008221 formate C-acetyltransferase Proteins 0.000 description 1
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
• SZGAAHDUAFVZSS-SFYZADRCSA-N forosamine Chemical compound C[C@@H](O)[C@@H](N(C)C)CCC=O SZGAAHDUAFVZSS-SFYZADRCSA-N 0.000 description 1
• 239000000446 fuel Substances 0.000 description 1
• 230000002538 fungal effect Effects 0.000 description 1
• 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 108091008053 gene clusters Proteins 0.000 description 1
• 102000034356 gene-regulatory proteins Human genes 0.000 description 1
• 108091006104 gene-regulatory proteins Proteins 0.000 description 1
• 125000002350 geranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 230000001890 gluconeogenic effect Effects 0.000 description 1
• 229930195712 glutamate Natural products 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 108010016102 glutamine transport proteins Proteins 0.000 description 1
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
• KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
• 230000002414 glycolytic effect Effects 0.000 description 1
• 125000003147 glycosyl group Chemical group 0.000 description 1
• 229940029575 guanosine Drugs 0.000 description 1
• 208000019622 heart disease Diseases 0.000 description 1
• 230000002363 herbicidal effect Effects 0.000 description 1
• 239000004009 herbicide Substances 0.000 description 1
• 244000038280 herbivores Species 0.000 description 1
• 238000012165 high-throughput sequencing Methods 0.000 description 1
• 229940099552 hyaluronan Drugs 0.000 description 1
• KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• 101150006815 icsA gene Proteins 0.000 description 1
• 101150033780 ilvB gene Proteins 0.000 description 1
• 101150020087 ilvG gene Proteins 0.000 description 1
• 230000002519 immonomodulatory effect Effects 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 230000028993 immune response Effects 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 235000013666 improved nutrition Nutrition 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 201000007119 infective endocarditis Diseases 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 239000003999 initiator Substances 0.000 description 1
• 230000000749 insecticidal effect Effects 0.000 description 1
• 239000002917 insecticide Substances 0.000 description 1
• 230000010354 integration Effects 0.000 description 1
• 230000008611 intercellular interaction Effects 0.000 description 1
• 230000035990 intercellular signaling Effects 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
• CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
• 235000008696 isoflavones Nutrition 0.000 description 1
• 101150068863 ispE gene Proteins 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 229940001882 lactobacillus reuteri Drugs 0.000 description 1
• 210000001069 large ribosome subunit Anatomy 0.000 description 1
• 238000000707 layer-by-layer assembly Methods 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 230000000503 lectinlike effect Effects 0.000 description 1
• 229930013686 lignan Natural products 0.000 description 1
• 150000005692 lignans Chemical class 0.000 description 1
• 235000009408 lignans Nutrition 0.000 description 1
• 235000019421 lipase Nutrition 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 230000028744 lysogeny Effects 0.000 description 1
• 229940041033 macrolides Drugs 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 125000000346 malonyl group Chemical group C(CC(=O)*)(=O)* 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 239000002609 medium Substances 0.000 description 1
• RAKQPZMEYJZGPI-LJWNYQGCSA-N menaquinone-7 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 RAKQPZMEYJZGPI-LJWNYQGCSA-N 0.000 description 1
• 235000009464 menaquinone-7 Nutrition 0.000 description 1
• 239000011700 menaquinone-7 Substances 0.000 description 1
• 239000002207 metabolite Substances 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 230000037230 mobility Effects 0.000 description 1
• 102000035118 modified proteins Human genes 0.000 description 1
• 108091005573 modified proteins Proteins 0.000 description 1
• 230000036457 multidrug resistance Effects 0.000 description 1
• 229940051921 muramidase Drugs 0.000 description 1
• 231100000219 mutagenic Toxicity 0.000 description 1
• 230000003505 mutagenic effect Effects 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 101150090227 ncd-2 gene Proteins 0.000 description 1
• 201000008383 nephritis Diseases 0.000 description 1
• HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 108020001162 nitroreductase Proteins 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 230000000426 osmoregulatory effect Effects 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 230000008723 osmotic stress Effects 0.000 description 1
• 101150034999 otsA gene Proteins 0.000 description 1
• 230000002018 overexpression Effects 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000005895 oxidative decarboxylation reaction Methods 0.000 description 1
• 239000001301 oxygen Substances 0.000 description 1
• 229910052760 oxygen Inorganic materials 0.000 description 1
• 150000002960 penicillins Chemical class 0.000 description 1
• 101150022503 phoR gene Proteins 0.000 description 1
• 229930029653 phosphoenolpyruvate Natural products 0.000 description 1
• 108010035774 phosphoribosylaminoimidazole carboxylase Proteins 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 229930001119 polyketide Natural products 0.000 description 1
• 150000003881 polyketide derivatives Chemical class 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 239000001205 polyphosphate Substances 0.000 description 1
• 108020000161 polyphosphate kinase Proteins 0.000 description 1
• 235000011176 polyphosphates Nutrition 0.000 description 1
• 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 230000003449 preventive effect Effects 0.000 description 1
• 230000002250 progressing effect Effects 0.000 description 1
• 108010007439 proline transporter Proteins 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• QAQREVBBADEHPA-IEXPHMLFSA-N propionyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QAQREVBBADEHPA-IEXPHMLFSA-N 0.000 description 1
• 230000004952 protein activity Effects 0.000 description 1
• 238000002731 protein assay Methods 0.000 description 1
• 235000004252 protein component Nutrition 0.000 description 1
• 230000020978 protein processing Effects 0.000 description 1
• 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
• 108010020248 psaB subunit photosystem I Proteins 0.000 description 1
• 210000004196 psta Anatomy 0.000 description 1
• 101150035806 purK gene Proteins 0.000 description 1
• 239000012264 purified product Substances 0.000 description 1
• 239000002213 purine nucleotide Substances 0.000 description 1
• 230000018612 quorum sensing Effects 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1
• 230000009711 regulatory function Effects 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 210000004767 rumen Anatomy 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 101150108659 secA gene Proteins 0.000 description 1
• 101150114545 secE gene Proteins 0.000 description 1
• 230000028043 self proteolysis Effects 0.000 description 1
• 230000001953 sensory effect Effects 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 238000010532 solid phase synthesis reaction Methods 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 230000009182 swimming Effects 0.000 description 1
• 238000001308 synthesis method Methods 0.000 description 1
• 150000003505 terpenes Chemical class 0.000 description 1
• 210000001519 tissue Anatomy 0.000 description 1
• 230000017423 tissue regeneration Effects 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 230000002103 transcriptional effect Effects 0.000 description 1
• 108010039189 tripeptidyl-peptidase 2 Proteins 0.000 description 1
• 201000008827 tuberculosis Diseases 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
• 229940045145 uridine Drugs 0.000 description 1
• 230000002485 urinary effect Effects 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 239000003981 vehicle Substances 0.000 description 1
• 230000029663 wound healing Effects 0.000 description 1
• 101150020830 yceM gene Proteins 0.000 description 1
• 235000013618 yogurt Nutrition 0.000 description 1