CA2501756C - Isolated post-translationally modified proteins for monitoring and diagnosing muscle damage - Google Patents

Isolated post-translationally modified proteins for monitoring and diagnosing muscle damage Download PDF

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Publication number
CA2501756C
CA2501756C CA2501756A CA2501756A CA2501756C CA 2501756 C CA2501756 C CA 2501756C CA 2501756 A CA2501756 A CA 2501756A CA 2501756 A CA2501756 A CA 2501756A CA 2501756 C CA2501756 C CA 2501756C
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CA
Canada
Prior art keywords
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glu
leu
arg
ala
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2501756A
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English (en)
French (fr)
Other versions
CA2501756A1 (en
Inventor
Jennifer E. Van Eyk
Jeremy A. C. Simpson
Ninetta Buscemi
Michelle K. Quick
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Queens University at Kingston
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Queens University at Kingston
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Publication of CA2501756A1 publication Critical patent/CA2501756A1/en
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Publication of CA2501756C publication Critical patent/CA2501756C/en
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
CA2501756A 2002-10-11 2003-10-10 Isolated post-translationally modified proteins for monitoring and diagnosing muscle damage Expired - Fee Related CA2501756C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/270,838 2002-10-11
US10/270,838 US7196169B2 (en) 2002-10-11 2002-10-11 Isolated post-translationally modified mammalian proteins for monitoring and diagnosing muscle damage
PCT/CA2003/001523 WO2004034060A2 (en) 2002-10-11 2003-10-10 Isolated post-translationally modified proteins for monitoring and diagnosing muscle damage

Publications (2)

Publication Number Publication Date
CA2501756A1 CA2501756A1 (en) 2004-04-22
CA2501756C true CA2501756C (en) 2013-01-29

Family

ID=32069017

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2501756A Expired - Fee Related CA2501756C (en) 2002-10-11 2003-10-10 Isolated post-translationally modified proteins for monitoring and diagnosing muscle damage

Country Status (6)

Country Link
US (1) US7196169B2 (https=)
EP (1) EP1554587A2 (https=)
JP (1) JP2006502203A (https=)
AU (1) AU2003273674A1 (https=)
CA (1) CA2501756C (https=)
WO (1) WO2004034060A2 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618782B1 (en) 1999-10-18 2009-11-17 Queen's University At Kingston Methods of diagnosing muscle damage
CN100553636C (zh) 2000-08-04 2009-10-28 Dmi生物科学公司 二酮基哌嗪和包含它们的组合物的使用方法
EP1311860A2 (en) * 2000-08-21 2003-05-21 Queen's University At Kingston Methods and kits for separation and detection of proteins in biological samples
WO2004030522A2 (en) 2002-10-02 2004-04-15 Dmi Biosciences, Inc. Diagnosis and monitoring of diseases
EP2517718B1 (en) 2003-05-15 2016-03-02 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
ES2367311T3 (es) * 2004-04-15 2011-11-02 University Of Florida Research Foundation, Inc. Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales.
US20080305512A1 (en) * 2006-10-26 2008-12-11 Mattingly Phillip G Assay for cardiac troponin autoantibodies
EP2097750A2 (en) * 2006-10-26 2009-09-09 Abbott Laboratories Immunoassay of analytes in samples containing endogenous anti-analyte antibodies
US7776605B2 (en) * 2006-10-26 2010-08-17 Abbott Laboratories Assay for cardiac troponin autoantibodies
CN1974594B (zh) * 2006-11-16 2010-04-14 中国人民解放军军事医学科学院卫生学环境医学研究所 人心肌肌钙蛋白ⅰ亚基核酸适配子及应用
US8207301B2 (en) 2007-06-20 2012-06-26 Nec Corporation Hepatocellular carcinoma protein marker
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
WO2011103330A2 (en) * 2010-02-17 2011-08-25 The Johns Hopkins University Novel phosphorylation of cardiac troponin i as a monitor for cardiac injury
EP2613786A4 (en) 2010-09-07 2013-10-23 Dmi Acquisition Corp TREATMENT OF DISEASES
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EA028343B1 (ru) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Лечение дегенеративного заболевания сустава
EP2771007B1 (en) 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
WO2013085367A1 (en) * 2011-12-09 2013-06-13 Kyungpook National University Industry-Academic Cooperation Foundation Cardiac troponin i-targeting peptide and use thereof
BR112015020469A2 (pt) 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
RU2736513C2 (ru) 2014-08-18 2020-11-17 Ампио Фармасьютикалз, Инк. Лечение патологических состояний суставов
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
CN111662909B (zh) * 2019-03-05 2022-07-15 中国科学技术大学 心肌肌钙蛋白i特异性核酸适配体及其应用
BR102021020613A2 (pt) * 2021-10-14 2023-04-18 Universidade Federal Do Rio De Janeiro Método de investigação proteômica em amostra para diagnóstico da rabdomiólise e kits para realização do mesmo

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU689777B2 (en) 1993-05-17 1998-04-09 Fortron Bioscience, Inc. Assay for cardiac troponin I
US5702905A (en) 1994-09-28 1997-12-30 Spectral Diagnostics Monoclonal antibody to human ventricular myosin light chains
US5795725A (en) 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
US6227658B1 (en) 1997-06-23 2001-05-08 Kabushiki Kaisha Toshiba Apparatus and method for forming thin film using ink-jet mechanism
US7384751B1 (en) 1997-07-16 2008-06-10 Queen's University At Kingston Methods of diagnosing muscle damage
US6248546B1 (en) * 1998-03-09 2001-06-19 Diagnostic Systems Laboratories, Inc. Assay of IGFBP complex

Also Published As

Publication number Publication date
EP1554587A2 (en) 2005-07-20
US20040072255A1 (en) 2004-04-15
JP2006502203A (ja) 2006-01-19
WO2004034060A3 (en) 2005-03-03
CA2501756A1 (en) 2004-04-22
US7196169B2 (en) 2007-03-27
AU2003273674A1 (en) 2004-05-04
WO2004034060A2 (en) 2004-04-22

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