CA2496800A1 - Antiplaque enzyme containing dual component composition - Google Patents

Antiplaque enzyme containing dual component composition Download PDF

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Publication number
CA2496800A1
CA2496800A1 CA002496800A CA2496800A CA2496800A1 CA 2496800 A1 CA2496800 A1 CA 2496800A1 CA 002496800 A CA002496800 A CA 002496800A CA 2496800 A CA2496800 A CA 2496800A CA 2496800 A1 CA2496800 A1 CA 2496800A1
Authority
CA
Canada
Prior art keywords
composition
enzyme
components
antibacterial
metal salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002496800A
Other languages
French (fr)
Other versions
CA2496800C (en
Inventor
James R. Brown
Lori H. Szeles
Susan M. Herles
Michael Prencipe
James G. Masters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Colgate Palmolive Co
Original Assignee
James R. Brown
Lori H. Szeles
Susan M. Herles
Michael Prencipe
James G. Masters
Colgate-Palmolive Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James R. Brown, Lori H. Szeles, Susan M. Herles, Michael Prencipe, James G. Masters, Colgate-Palmolive Company filed Critical James R. Brown
Publication of CA2496800A1 publication Critical patent/CA2496800A1/en
Application granted granted Critical
Publication of CA2496800C publication Critical patent/CA2496800C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits

Abstract

A two component antiplaque dentifrice composition is disclosed which comprises first and second dentifrice components containing an enzyme such as papain and a metal salt such as stannous fluoride, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth.

Claims (22)

1. A dual component dentifrice composition having superior antibacterial efficacy which comprises first and second dentifrice components which contain an enzyme and an antibacterial metal salt in separate orally acceptable dentifrice vehicles, and in which an anionic surfactant is present solely in the dentifrice vehicle containing the metal salt, the first and second components being maintained separate from each other until dispensed and combined for application to teeth whereby heightened antibacterial efficacy against plaque causing oral bacteria is obtained.
2. The composition of Claim 1 wherein the enzyme is papain.
3. The composition of Claim 1 wherein the enzyme is glucoamylase.
4. The composition of Claim 1 wherein the antibacterial metal salt is a stannous salt.
5. The composition of Claim 1 wherein the antibacterial metal salt is SnF2.
6. The composition of Claim 4 wherein the stannous salt is a combination of SnF2 an SnCl2.
7. The composition of Claim 4 wherein the stannous salt and enzyme are combined in the first component.
8. The composition of Claim 4 wherein the stannous salt and enzyme are present in separate components.
9. The composition of Claim 1 wherein the enzyme is present in the composition at a concentration of about 0.05 to about 5% by weight.
10. The composition of Claim 1 wherein the antibacterial metal salt is present in the composition at a concentration of about 1 to about 5% try weight.
11. A method for improving the antibacterial efficacy of an oral care composition comprising preparing first and second dentifrice components containing art enzyme and an antibacterial metal salt in separate an orally acceptable dentifrice vehicles, and in which an anionic surfactant is present solely in the dentifrice vehicle containing the metal salt, separately housing the first and second components, dispensing the first and second components simultaneously, combining the dispensed components and thereafter applying the combined components to the teeth whereby heightened antibacterial efficacy against plaque causing oral bacteria is obtained.
12. The method of Claim 11 wherein the enzyme is papain.
13. The method of Claim 11 wherein the enzyme is glucoamylase.
14. The method of Claim 14 wherein the antibacterial metal salt is a stannous salt.
15. The method of Claim 14 wherein the antibacterial stannous salt is SnF2.
16. The method of Claim 15 wherein the antibacterial stannous salt is a combination of SnF2 and SnCl2.
17. The method of Claim 11 wherein the antibacterial stannous salt is present in the composition. at a concentration of about 1 to about 5% by weight.
18. The method of Claim 11 wherein the enzyme is present in the composition at a concentration of about 0.05 to about 5% by weight.
19. The method of Claim 11 wherein the stannous salt is present in the composition at a concentration of about 1 to about 5% by weight.
20. The method of Claim 11 wherein the metal salt and enzyme are combined in the first component.
21. The method of Claim 11 wherein the metal salt and enzyme are present in separate components.
22. The method of Claim 11 wherein the first and second components are housed in a common container and are separated from one another by a wall integrally formed with the container which prevents mixing of the components prior to being dispensed.
CA2496800A 2002-08-28 2003-08-26 Antiplaque enzyme containing dual component composition Expired - Fee Related CA2496800C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/229,622 2002-08-28
US10/229,622 US6652841B1 (en) 2002-08-28 2002-08-28 Antiplaque enzyme containing dual component composition
PCT/US2003/026578 WO2004019898A1 (en) 2002-08-28 2003-08-26 Antiplaque enzyme containing dual component composition

Publications (2)

Publication Number Publication Date
CA2496800A1 true CA2496800A1 (en) 2004-03-11
CA2496800C CA2496800C (en) 2012-12-11

Family

ID=29584102

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2496800A Expired - Fee Related CA2496800C (en) 2002-08-28 2003-08-26 Antiplaque enzyme containing dual component composition

Country Status (11)

Country Link
US (1) US6652841B1 (en)
EP (1) EP1531787A1 (en)
CN (1) CN1688280B (en)
AU (1) AU2003262849B2 (en)
BR (1) BR0313953A (en)
CA (1) CA2496800C (en)
MX (1) MXPA05002244A (en)
PL (1) PL375566A1 (en)
RU (1) RU2300366C2 (en)
WO (1) WO2004019898A1 (en)
ZA (1) ZA200502420B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100534413C (en) * 2001-12-25 2009-09-02 花王株式会社 Compositions for mouth
US7402416B2 (en) * 2002-05-10 2008-07-22 Colgate-Palmolive Company Antibacterial dentifrice exhibiting antiplaque and breath freshening properties
US6927053B2 (en) * 2002-08-28 2005-08-09 Colgate-Palmolive Company Dual component dental composition containing enzyme
US20040120900A1 (en) * 2002-12-20 2004-06-24 Peter Arsenault Intraoral calculus dissolving gel composition
US9023323B2 (en) * 2004-12-16 2015-05-05 Colgate-Palmolive Company Oral compositions for prevention and reduction of bacterial adhesion to oral surfaces
US8894977B2 (en) 2004-12-16 2014-11-25 Colgate-Palmolive Company Oral treatment compositions containing an anti-adhesion agent, antibacterial agent and incompatible compound
ES2364759T3 (en) * 2004-12-16 2011-09-13 Colgate-Palmolive Company COMPOSITIONS FOR THE ORAL TREATMENT CONTAINING AN ANTI-ADHESION AGENT, ANTIBACTERIAL AGENT AND INCOMPATIBLE COMPOUND.
USPP17721P3 (en) * 2005-07-28 2007-05-15 Syngenta Seeds B.V. Ageratum plant named ‘Agbic’
PL1965751T3 (en) 2005-11-23 2017-03-31 Colgate-Palmolive Company Stannous salt and sodium tripoly-phosphate oral care compositions and methods
SG173787A1 (en) 2009-04-02 2011-09-29 Colgate Palmolive Co Exfoliating dentifrice composition and method of use
FR2981846B1 (en) * 2011-10-28 2015-09-04 Sensient Cosmetic Technologies AQUEOUS PIGMENTARY COSMETIC DISPERSION BASED ON NATURAL PRODUCTS AND ITS COSMETIC USES.
US10123953B2 (en) * 2012-06-21 2018-11-13 The Procter & Gamble Company Reduction of tooth staining derived from cationic antimicrobials
RU2494725C1 (en) * 2012-08-20 2013-10-10 Общество С Ограниченной Ответственностью "Сплат-Косметика" (Ооо "Сплат-Косметика") Mineral enzymatic complex for enamel strengthening and whitening, oral hygiene composition and tooth paste
AR096355A1 (en) * 2014-05-20 2015-12-23 Brix S R L DENTAL COMPOSITION OF GEL PAPAINE FOR ATRAUMATIC TREATMENT OF CARIES AND METHOD TO PREPARE IT
EP3244872B1 (en) 2015-07-01 2021-05-12 Colgate-Palmolive Company Oral care compositions and methods of use
CN108472209B (en) 2015-12-30 2021-06-25 高露洁-棕榄公司 Personal care compositions
WO2017117155A1 (en) 2015-12-30 2017-07-06 Colgate-Palmolive Company Personal care compositions
CN108463208B (en) 2015-12-30 2021-12-07 高露洁-棕榄公司 Oral care compositions
CN109069391B (en) 2015-12-30 2022-02-11 高露洁-棕榄公司 Oral care compositions
WO2017219339A1 (en) 2016-06-24 2017-12-28 Colgate-Palmolive Company Oral care compositions and methods of use
CN114010530B (en) * 2021-11-11 2023-11-28 上海佩格医院管理有限公司 Composition for oral care and application thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946725A (en) * 1957-03-25 1960-07-26 Procter & Gamble Dentifrice compositions
BE638714A (en) * 1958-05-29
ZA695572B (en) * 1968-08-09 1971-03-31 Colgate Palmolive Co Oral preparation
US4152418A (en) * 1970-04-01 1979-05-01 Lever Brothers Company Zinc and enzyme mouthwash and mouthwash concentrate for reducing dental plaque and calculus formation
CA959764A (en) * 1971-02-09 1974-12-24 Morton Pader Dentifrice
US4082841A (en) * 1975-10-10 1978-04-04 Lever Brothers Company Dentifrice
US5281410A (en) * 1991-10-23 1994-01-25 The Proctor & Gamble Company Methods of reducing plaque and gingivitis with reduced staining
US5320831A (en) * 1992-12-30 1994-06-14 The Procter & Gamble Company Oral compositions
GB2290234B (en) * 1994-06-07 1998-06-10 Janina International Oral care products
US5843409A (en) * 1994-08-08 1998-12-01 Colgate Palmolive Company Two component dentifrice for the treatment of dentinal hypersensitivity
US6350436B1 (en) * 1996-11-21 2002-02-26 The Procter & Gamble Company Method of reducing staining of stannous in dentifrice compositions
US6187295B1 (en) * 1996-11-21 2001-02-13 The Procter & Gamble Company Methods of reducing the astringency of stannous in dentifrice compositions
US5932192A (en) * 1997-04-23 1999-08-03 Colgate-Palmolive Company Lower astringent two component stannous and potassium salt containing dentifrice
US5780015A (en) * 1997-05-14 1998-07-14 Colgate Palmolive Company Dentifrice for the treatment of dentinal hypersensitivity having limited astringency
US6464963B1 (en) * 1998-04-23 2002-10-15 Colgate Palmolive Company Desensitizing dentifrice containing potassium and tin salts
PE20020237A1 (en) * 2000-06-30 2002-04-18 Procter & Gamble TOPICAL ORAL COMPOSITION
US6379654B1 (en) * 2000-10-27 2002-04-30 Colgate Palmolive Company Oral composition providing enhanced tooth stain removal

Also Published As

Publication number Publication date
CN1688280B (en) 2010-05-12
RU2005108607A (en) 2005-09-10
MXPA05002244A (en) 2005-06-08
CA2496800C (en) 2012-12-11
CN1688280A (en) 2005-10-26
BR0313953A (en) 2005-07-19
AU2003262849A1 (en) 2004-03-19
RU2300366C2 (en) 2007-06-10
ZA200502420B (en) 2006-05-31
WO2004019898A1 (en) 2004-03-11
PL375566A1 (en) 2005-11-28
EP1531787A1 (en) 2005-05-25
AU2003262849B2 (en) 2009-05-07
US6652841B1 (en) 2003-11-25

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Effective date: 20170828