CN101111216B

CN101111216B - Multiphase toothpaste composition

Info

Publication number: CN101111216B
Application number: CN2006800038657A
Authority: CN
Inventors: N·S·比拉尼; D·P·格雷戈里; B·格罗夫斯
Original assignee: Unilever NV
Current assignee: Unilever NV
Priority date: 2005-02-04
Filing date: 2006-01-12
Publication date: 2013-07-10
Anticipated expiration: 2026-01-12
Also published as: CN101111218B; CN101111214A; CN101111216A; CN101111217A; CN101111218A; CN101111215A

Abstract

The present invention relates to a multiphase toothpaste composition which includes a first phase that is coaxially arranged in the second gel phase that is clear by visual sensation, and the second phase includes the paint and the concentration of the paint ranges from 1ppm to 100ppm.

Description

Multiphase toothpaste composition

The present invention relates to a kind of multiphase toothpaste composition, it phase that comprises clarification and core be (core phase) mutually.

WO99/01342 discloses the device that is used for multiple material is inserted container.This device comprises the mouth of pipe, second hollow member that this mouth of pipe has first hollow member and arranges in first hollow member.This mouth of pipe is designed to that multiple toothpaste phase extrudate is introduced one and is disposed in mutually in another toothpaste container in mutually.

Although prior art still needs to have the visual effect of improvement and the multiphase toothpaste composition of cleaner appearance more.

The inventor finds to comprise that a spot of pigment can reach the visual effect of improvement among the foreign minister by clarification visually, and " dirty " outer harmony in the exterior of minimizing is cleaner appearance more better.Therefore, in first aspect, the invention provides a kind of multiphase toothpaste according to claim 1.

Visually Cheng Qing the meaning is by the outside, and second can see inside, first phase mutually.

Arranged in co-axial alignment in first gel phase of visually clarifying mutually.This refers to work as and divides the longitudinal axis of this ribbon of timing to be in inside by toothpaste container, first phase.Similarly, the general longitudinal axis of this toothpaste (general longitudinal axis) is in the inside of wherein storing, first phase when storing in toothpaste container.Should be appreciated that such arrangement is by judging on naked eyes rather than the mathematics.

When observe distributing the cross section of ribbon terminal, interiorly can extend or until ribbon outer surface to the ribbon outer surface mutually.Such extension can be radial, helical form or abstract, and when it is radial or helical form, can be regular or irregular.Radial extension for consumer's rule is most preferred.In addition, this core can be Any shape in cross section, for example star, square, triangle etc.The core of these shapings is subjected to the real welcome of young consumers.Yet, do not comprise the core of extending and only ribbon being provided rule alternatively in most preferably mutually.This regular shape do not have fussy ornament and for product provides clean and tidy lines, and this has strengthened the impression that toothpaste aims to provide cleaning.

Preferably, pigment is not water miscible.

Preferably, the foreign minister comprises 10 to 70ppm, more preferably 35 to 65ppm pigment.

Preferred blue pigment can be selected from the commercially available phthalocyanine blue pigment of Meilida Pigment Industry Co.

Various blue pigments comprise:

Phthalocyanine Blue BGS

Phthalocyanine blue b GNCF-03

Phthalocyanine Blue BGS P

Phthalocyanine blue b RSH filter cake

Phthalocyanine blue b RX

Phthalocyanine blue b RXH

Phthalocyanine blue M-3000

Phthalocyanine blue 94817D

Phthalocyanine Blue BGS-W

Phthalocyanine blue b RS

Phthalocyanine blue b RSS

Phthalocyanine blue b RX filter cake

Phthalocyanine blue M-1000HF

Most preferred blue pigment is phthalocyanine blue pigment CI No.74260.

Preferred red pigment comprises Cosmetic Pink (Cosmetic Pink).Most preferred Cosmetic Pink is Cosmetic Pink CI-73360.

Most preferred viridine green is phthalocyanine green, preferred phthalocyanine green CI-74260.

In a preferred embodiment and when toothpaste interior be white or when blue, the low-level pigment that preferably uses in the foreign minister is blue mutually.

In a preferred embodiment and when toothpaste interior was green mutually, the low-level pigment that preferably uses in the foreign minister was green.

In a preferred embodiment and when toothpaste interior was redness mutually, the low-level pigment that preferably uses in the foreign minister was red.

The levels of pigment of this type of minimizing has significantly been improved the sensation of the interior phase among the foreign minister.The cleaning benefit that provided by this class toothpaste has been provided for this.

One preferred embodiment in, inside, interior mutually opaque.This has increased extra benefit, because produced the silver color effect at two-phase interface.This is to the very attractive effect of consumer.

When coloured the time, the interior pigment that accounts for this phase 0.01-0.2% weight that comprises mutually of toothpaste.Preferably, pigment is selected from for those of foreign minister.More preferably, pigment interior mutually in the 0.03-0.15% of interior phase weight, most preferably about 0.08% amount exists.

When toothpaste interior mutually opaque, can provide opacity by any known opacifier, but preferred Chalk or titanium dioxide.

Preferably, interior at the most 25% of the toothpaste volume that accounts for mutually.Use accounts for 25% inside first phase at the most of dentifrice composition volume, the visual effect that can be improved.If interior mutually shared compositions volume is much larger than 25%, often show as covering (overwhelm) mutually to such an extent as to said composition consumer is difficult to notice the foreign minister at all in then.This only is when the situation of foreign minister when visually clarifying in the present invention.

Preferably, inner first accounts for 11 to 20% of dentifrice composition volume mutually, and more preferably 13 to 18%.

About their principle (principle) component, i.e. thickening agent, activating agent, structural agent and grinding agent, first and second mutually can be identical or different.When first and second when mutually basic identical, their accessory constituent, for example pigment or spice can be different.Have two phases of visually clarifying and also provide a kind of attractive compositions for consumer.

In a further preferred embodiment, the outside, visually clarification comprises abrasive silica mutually.The particular abrasive silica that the present invention uses is a kind of silicon dioxide of low-refraction.It can be used as independent abrasive silica and uses, or with low-level other abrasive silica, for example unite use according to those of EP236070.In the present invention the low refractive index silica that uses as grinding agent preferably apparent refractive index (R.I.) scope be the silicon dioxide of 1.41-1.47, preferred 1.435-1.445 preferably has the average particle size of 5-15mm, BET (nitrogen) surface area is 10 to 100m ²/ g, oil absorption are about 70-150cm ³/ 100g, but the abrasive silica of lower apparent refractive index also can be used.The representative instance of the low refractive index abrasive silicas (for example having the R.I. between 1.435 to 1.445) that is fit to is Tixosil 63 and 73, from Rhone Poulenc; Sident10 is from Degussa; Zeodent 113, from Zeofinn; Zeodent 124, from Huber; Sorbosil AC77 is from Crosfield Chemicals (have about 1.440 R.I.).The scope of these silica volumes generally is 5-60% weight in the compositions, is generally 5-20% weight.

Inner in a preferred embodiment, the opaque Chalk that comprises mutually, the preferably natural whiting of fine ground.Inner composition preferably includes the Chalk that accounts for this phase weight 10 to 60%.

The method preparation of use standard is according to each phase of compositions of the present invention.Can be by detailed disclosed equipment among the WO99/01342 for example, the coaxial mouth of pipe assembly that namely is connected with standard device is extruded into it in dispense container.

In a most preferred embodiment, when on the Brookfield RV DV-1 viscometer that is being equipped with the Helipath support at 25 ℃ and when using the T-D spindle to measure with 5rpm, the viscosity that the phase of thing combined according to the invention has is 150000Pa.s to 250000mPa.s.This viscosity provides about being expressed into the optimum performance that the container neutralization is extruded from container by consumer.In this range of viscosities each is much more stable physically mutually than other in extrusion.

Can comprise the reagent that is selected from dental caries agent (anti carriesagents), brightener for tooth, anticalculus agent, halitosis agent, antigingivitis agent and composition thereof according to dentifrice composition of the present invention.

Dentifrice composition comprises further composition commonly used in the art, for example:

Antimicrobial, for example, chlorhexidine, the Sanguinarine extract, metronidazole, quaternary ammonium compound is cetylpyridinium chloride for example, and biguanide is chlorhexidine digluconate, hexetidine, octenidine, the western pyridine of Ah Lai for example; With halogenated bisphenol chemical compound for example 2,2 '-di-2-ethylhexylphosphine oxide-(4-chloro-6-bromophenol);

Antiinflammatory, for example ibuprofen, BTS-18322, aspirin, indomethacin etc.;

The dental caries agent, for example sodium fluoride and stannous fluoride, amine fluoride, sodium monofluorophosphate, sodium trimetaphosphate and casein;

Bacterial plaque buffer, for example carbamide, calcium lactate, calcium glycerophosphate and polyacrylic acid strontium;

Vitamin, for example vitamin A, C and E;

Plant extract;

Desensitizer, for example potassium citrate, potassium chloride, Soluble tartar., potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salt;

Anticalculus agent, for example alkali metal pyrophosphate, the polymer that contains hypophosphites, organic phosphonate and phosphoric acid citrate (phosphocitrates) etc.;

Biomolecule, for example bacteriocin, antibody, enzyme etc.;

Spice, for example Herba Menthae and Oleum menthae;

Proteinaceous material, for example collagen;

Antiseptic;

Opacifier;

Coloring agent;

The pH regulator agent;

Sweeting agent;

Pharmaceutical acceptable carrier, for example, starch, sucrose, water or water/pure system etc.;

Surfactant, for example anion, nonionic, cation and amphion or amphoteric surfactant;

The microgranule abrasive materials, for example silicon dioxide, aluminium oxide, calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydroxyapatite, trimetaphosphate, insoluble hexametaphosphate etc., the microgranule abrasive materials that comprises agglomeration, content are generally 3 to 60% of oral care composition weight.Preferred grinding agent is Chalk and silicon dioxide, more preferably the natural whiting of fine ground.

Wetting agent, for example glycerol, sorbitol, propylene glycol, xylitol, lactose etc.; Preferably, the foreign minister of toothpaste comprises the wetting agent that accounts for corresponding phase weight 55 to 70%.Preferably, be the sorbitol that accounts for this phase weight 55 to 70%.Sorbitol typically exists with 70% aqueous solution.

Binding agent and thickening agent, for example sodium carboxymethyl cellulose, hydroxyethyl-cellulose (

), xanthan gum, arabic gum etc., and synthetic polymer, for example polyacrylate and carboxy vinyl polymer are for example

Also can comprise can the enhanced activity composition polymer sent of antimicrobial for example;

Buffer agent and the salt of buffering oral care composition pH and ionic strength; And

Other optional members that can comprise are bleachs for example, for example peroxide peroxide diphosphonic acid potassium (potassium peroxydiphosphate) for example; Effervescent system is the sodium bicarbonate/citric acid system for example, color change system, etc.

Also can use liposome to improve sending of active component or stability.

In second aspect, the invention provides a kind of toothpaste container that comprises as described first and second phases of in tubular container, storing of first aspect present invention, this container comprises the body that an end is wrinkling, comprises allocation component at the other end, and consumer is by this assembly extruding composition.

Preferably, tubular container is transparent or semitransparent in order to can see the interior phase among the foreign minister in the container.

With non-limiting example embodiments of the present invention are discussed now.

Embodiment

Said composition comprise first mutually with second mutually.The second mutually clarification visually, and interior be opaque mutually.Said composition comprise 85%v/v first mutually and 15%v/v second mutually.

Composition	The first phase % (w/w)	The second phase % (w/w)
			Water	12.73	12.48
Sorbitol (70% aqueous solution)	63.00	63.00
			Sodium fluoride	0.32	0.32
Polyethylene Glycol (PEG 32)	4.00	4.00
			Titanium dioxide	0.00	0.50
Thickening property silicon dioxide	9.25	9.00
			Abrasive silica	8.00	8.00
Sodium carboxymethyl cellulose	0.90	0.90
			Sodium lauryl sulfate	1.80	1.80
Phthalocyanine blue pigment CI No.74260	0.08	40ppm
			Spice	Trace	Trace

Claims

1. multiphase toothpaste composition, it is included in first phase of arranged in co-axial alignment in second gel phase of clarification visually, and second comprises the pigment of 1ppm to 100ppm mutually, and wherein this first accounts at the most 25% of toothpaste volume mutually,

Wherein said first is opaque mutually, and it comprises Chalk or titanium dioxide; And wherein said second the pigment in mutually is not water miscible.

2. according to the multiphase toothpaste of claim 1, it comprises the described pigment of 10ppm to 70ppm.

3. according to the multiphase toothpaste of claim 1 or 2, it comprises the described pigment of 35ppm to 65ppm.

4. according to the multiphase toothpaste of claim 1, wherein said pigment is blue.

5. according to the multiphase toothpaste of claim 4, wherein said blue pigment is phthalocyanine blue pigment.

6. according to the multiphase toothpaste of claim 5, wherein said blue pigment is phthalocyanine blue pigment CI No.74260.

7. according to the multiphase toothpaste of claim 1, wherein said pigment is red.

8. according to the multiphase toothpaste of claim 7, wherein said pigment is Cosmetic Pink.

9. according to the multiphase toothpaste of claim 7, wherein said pigment is Cosmetic Pink CI-73360.

10. according to the multiphase toothpaste of claim 1, wherein said pigment is green.

11. according to the multiphase toothpaste of claim 10, wherein said pigment is phthalocyanine green.

12. according to the multiphase toothpaste of claim 11, wherein said pigment is phthalocyanine green CI-74260.

13. according to the multiphase toothpaste of claim 1, wherein first account for 11 to 20% of dentifrice composition volume mutually.

14. according to the multiphase toothpaste composition of claim 1, wherein first account for 13 to 18% of dentifrice composition volume mutually.

15. according to the multiphase toothpaste composition of claim 1, wherein visually the gel phase of clarification comprises abrasive silica.

16. according to the multiphase toothpaste composition of claim 1, wherein visually the gel phase of clarification comprises the abrasive silica with 1.41 to 1.47 refractive indexs.