CN101111218B - Toothpaste - Google Patents

Abstract

The present invention relates to a toothpaste which includes a first and second compositions, and the first and second compositions include water, a wetting agent and a thickening agent, and the second composition is coaxially arranged in the first composition, the first composition is gel rubber and the second composition is opaque, the second composition includes a light screening agent which accounts for y percent of the second composition by weight, the weight percentage of the thickening agent included in the first composition is more than the weight percentage of the thickening agent existing in the second composition by 0.2 to 2.0y percent by weight of the first composition.

Description

Toothpaste

The present invention relates to a kind of toothpaste, it comprises first compositions and second compositions of arranged in co-axial alignment in first compositions.Each compositions comprises wetting agent, thickening agent and water.

WO99/01342 discloses a kind of device that is used for multiple material is inserted container.This device comprises the mouth of pipe, second hollow member that this mouth of pipe has first hollow member and arranges in first hollow member.This mouth of pipe is designed to that multiple toothpaste phase extrudate is introduced one and is disposed in mutually in another toothpaste container in mutually.

The invention provides a kind of improvement of toothpaste, it comprise one another mutually in the phase of arranged in co-axial alignment.

Second first mutually in arranged in co-axial alignment.This is meant to work as and divides the longitudinal axis of this ribbon of timing to be in inside by toothpaste container, second phase.Similarly, the general longitudinal axis of this toothpaste (general longitudinal axis) is in inside, second phase when storing in toothpaste container.Should be appreciated that such arrangement is by judging on naked eyes rather than the mathematics.

When observing the cross section of distributing the ribbon terminal, inner phase can extend or until ribbon outer surface to the ribbon outer surface.Such extension can be radial, helical form or abstract, and when it is radial or helical form, can be regular or irregular.Radial extension for consumer's rule is most preferred.In addition, this core can be Any shape in cross section, for example star, square, triangle etc.The core of these shapings is subjected to the real welcome of young consumers.Yet most preferably inner phase does not comprise the core of extending and only ribbon being provided rule alternatively.This regular shape do not have fussy ornament and for product provides clean and tidy lines, and this has strengthened the impression that toothpaste aims to provide cleaning.

Therefore, the invention provides a kind of toothpaste, it comprises first and second compositionss, first and second compositionss comprise water, wetting agent and thickening agent, and second compositions is arranged in co-axial alignment in first compositions, and first compositions is that the gel and second compositions are opaque, and second compositions comprises the opacifier that accounts for the second composition weight y%, and the percentage by weight that the thickening agent that first compositions comprises exists than thickening agent in second compositions manys 0.2-2.0y%, with first composition weight meter.

Careful balance thickening material can use the disclosed mouth of pipe of WO99/01342 to make toothpaste of the present invention most desirably be squeezed into dentifrice tube.Opacifier needs the careful balance of handling, because can cause rheol change.

Opacifier can be any opacifier known in the art, and wherein Chalk is that an example and titanium dioxide are another examples.Preferably, opacifier is a titanium dioxide.Provide best effect in the compositions of titanium dioxide in being stored in another compositions, because it presents the interface of silver color between first and second compositionss.This is the active factor that attracts consumer.

One preferred embodiment in, y, promptly the opacifier level of Cun Zaiing is 0.25 to 2% of second composition weight, and is preferred 0.3 to 1.2%, more preferably 0.4 to 0.7%, most preferably 0.5%.This provides the opaque of maximum horizontal and has not had to damage the rheological properties (rheology profile) of this type of composition so that there is not aequum to repair too bigly.

Toothpaste also contains inorganic natural or synthetic thickening agent or gellant, and its ratio is about 0.10 to about 15% weight according to selected material.Natural thickener exist level more much lower than inorganic thickening agent.Natural thickener exists with 0.2 level to about 1% weight of its place phase, and 2 to 15% weight that inorganic thickening agent can its place phase, the level of preferred 8 to 12% weight exists.The ratio of thickening agent forms extrudable, as to keep shape product in the Dentrifice composition of the present invention, and it can be pressed against on the toothbrush from pipe, and can not come off between bristle, but keeps its shape substantially on toothbrush.The thickening agent or the gellant that are fit to that use in the present invention's practice comprise inorganic thickening property silicon dioxide, and for example the trade name that obtains from Huber company (trade designation) is the amorphous silica of Zeodent 165, Irish moss, ι-carrageenin, gum tragacanth and polyethylene pyrrolidone.

Preferably thickening property silicon dioxide,, most preferably exists with 8 to 10% weight preferably with 7 to 13% weight with 5 to 15% of second composition weight in second compositions.

The amount of thickening agent is different from the amount of thickening agent in second compositions in first compositions because in first compositions than many in second compositions.This provides between two kinds of compositionss that caused by opacifier in second compositions balance between the different in addition rheological properties.

The percentage by weight that the thickening agent that first compositions comprises exists than thickening agent in second compositions manys 0.2-2.0y%, with first composition weight meter.Preferably, this thickening agent is a thickening property silicon dioxide.Preferably, the thickening agent that first compositions comprises manys 0.3 to 1.0y% than thickening agent in second compositions as what the second composition weight percentage ratio existed, more preferably 0.4 to 0.8y% and most preferably 0.45 to 0.55% weight.

In most preferred embodiments, in first compositions in the weight percent amount of thickening property silicon dioxide and second compositions weight percent amount be identical, but in second compositions, have the opacifier of the half amount that adds by thickening property silicon dioxide in first compositions in addition.

One preferred embodiment in, second compositions accounts for 5 to 25% of total toothpaste volume.Preferably, inner second composition constitutes long-pending 11 to 20%, more preferably 13 to 18%.

One preferred embodiment in, first compositions is visually clarifying.This is meant that by the outside first compositions can be seen inside, second compositions.

About their principle (principle) component, i.e. thickening agent, activating agent, structural agent and grinding agent, first and second compositionss can be identical or different.When first and second when mutually basic identical, their accessory constituent, for example coloring agent or spice can be different.Preferably, except about accessory constituent for example coloring agent and the spice, compositions is identical basically.

One preferred embodiment in, at least one is colored mutually.Preferably, the outside, first compositions is colored.Preferred color comprises green, redness, orange, yellow, blue, gold and purple.

In a further preferred embodiment, compositions comprises abrasive silica.The preferred abrasive silica that the present invention uses is a kind of silicon dioxide of low-refraction.It can be used as independent abrasive silica and uses, or with low-level other abrasive silica, for example unite use according to those of EP236070.The preferably apparent refractive index of low refractive index silica (R.I.) scope of using as grinding agent is the silicon dioxide of 1.41-1.47 in the present invention, and preferred 1.435-1.445 preferably has the average particle size of 5-15mm, and BET (nitrogen) surface area is 10 to 100m ²/ g, oil absorption are about 70-150cm ³/ 100g, but the abrasive silica of lower apparent refractive index also can be used.The representative instance of the low refractive index abrasive silicas (for example having the R.I. between 1.435 to 1.445) that is fit to is Tixosil 63 and 73, from Rhone Poulenc; Sident 10, from Degussa; Zeodent 113, from Zeofinn; Zeodent 124, from Huber; Sorbosil AC 77 is from Crosfield Chemicals (have about 1.440 R.I.).The scope of these silica volumes generally is a 5-60% weight in the compositions, is generally 5-20% weight.

The compositions of method preparation toothpaste of use standard according to the present invention.Can be by detailed disclosed equipment among the WO99/01342 for example, the coaxial mouth of pipe assembly that promptly is connected with standard device is extruded into it in dispense container.

In a most preferred embodiment, the compositions of toothpaste is 150000Pa.s to 250000mPa.s in the viscosity that is had on 25 ℃ of Brookfield RV DV-1 viscometers that are being equipped with the Helipath support and when using spindle to measure with 5rpm according to the present invention.Such viscosity provides about being expressed into the optimum performance that the container neutralization is extruded from container by consumer.In this range of viscosities each in extrusion than stable physically many of other phases.

Can comprise the reagent that is selected from dental caries agent (anti carriesagents), brightener for tooth, anticalculus agent, halitosis agent, antigingivitis agent and composition thereof according to dentifrice composition of the present invention.

Dentifrice composition comprises further composition commonly used in the art, for example:

Antimicrobial, for example, chlorhexidine, the Sanguinarine extract, metronidazole, quaternary ammonium compound is cetylpyridinium chloride for example, and biguanide is chlorhexidine digluconate, hexetidine, octenidine, the western pyridine of Ah Lai for example; With halogenated bisphenol chemical compound for example 2,2 '-di-2-ethylhexylphosphine oxide-(4-chloro-6-bromophenol);

Antiinflammatory, for example ibuprofen, BTS-18322, aspirin, indomethacin etc.;

The dental caries agent, for example sodium fluoride and stannous fluoride, amine fluoride, sodium monofluorophosphate, sodium trimetaphosphate and casein;

Bacterial plaque buffer, for example carbamide, calcium lactate, calcium glycerophosphate and polyacrylic acid strontium;

Vitamin, for example vitamin A, C and E;

Plant extract;

Desensitizer, for example potassium citrate, potassium chloride, Soluble tartar., potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salt;

Anticalculus agent, for example alkali metal pyrophosphate, the polymer that contains hypophosphites, organic phosphonate and phosphoric acid citrate (phosphocitrates) etc.;

Biomolecule, for example bacteriocin, antibody, enzyme etc.;

Spice, for example Herba Menthae and Oleum menthae;

Proteinaceous material, for example collagen;

Antiseptic;

Opacifier;

Coloring agent;

The pH regulator agent;

Sweeting agent;

Pharmaceutical acceptable carrier, for example, starch, sucrose, water or water/pure system etc.;

Surfactant, for example anion, nonionic, cation and amphion or amphoteric surfactant;

Microgranule abrasiveness material, for example silicon dioxide, aluminium oxide, calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydroxyapatite, trimetaphosphate, insoluble hexametaphosphate or the like, comprise agglomerant microgranule abrasiveness material, content is generally 3 to 60% of oral care composition weight.Preferred grinding agent is Chalk and silicon dioxide, more preferably the natural whiting of fine ground.

Wetting agent, for example glycerol, sorbitol, propylene glycol, xylitol, lactose etc.;

Binding agent and thickening agent, for example sodium carboxymethyl cellulose, hydroxyethyl-cellulose (

), xanthan gum, arabic gum etc., and synthetic polymer, for example polyacrylate and carboxy vinyl polymer are for example

Also can comprise can the enhanced activity composition polymer sent of antimicrobial for example;

The buffer agent and the salt of buffering oral care composition pH and ionic strength; And

Other optional members that can comprise are bleachs for example, for example peroxide peroxide diphosphonic acid potassium (potassium peroxydiphosphate) for example; Effervescent system is the sodium bicarbonate/citric acid system for example, color change system, or the like.

Also can use liposome to improve sending of active component or stability.

In second aspect, the invention provides a kind of toothpaste container that comprises as described first and second phases of in tubular container, storing of first aspect present invention, this container comprises the corrugated body of an end, comprises allocation component at the other end, and consumer is by this assembly extruding composition.

Preferably, tubular container is transparent or semitransparent so that can see the inner phase among the foreign minister in the container.

With non-limiting example embodiments of the present invention are discussed now.

Embodiment 1

Said composition comprises first compositions and second compositions.Second compositions is visually clarified, and inner phase is opaque.Said composition comprise 85%v/v first mutually and 15%v/v second mutually.

Composition	The first phase % (w/w)	The second phase % (w/w)
			Water	12.73	12.48
Sorbitol (70% aqueous solution)	63.00	63.00
			Sodium fluoride	0.32	0.32

Polyethylene Glycol (PEG 32)	4.00	4.00
			Titanium dioxide	0.00	0.50
Thickening property silicon dioxide	9.25	9.00
			Abrasive silica	8.00	8.00
Sodium carboxymethyl cellulose	0.90	0.90
			Sodium lauryl sulfate	1.80	1.80
Spice and coloring agent	Trace	Trace

Embodiment 2

Following evidence the rheology change relevant with adding small amount of opacifier, be titanium dioxide in this example.

Viscosity change during the demonstration shear rate changes among the figure.The change list of shear rate is shown in and is extruded in the pipe and by the different shear of experience during extruding in the pipe.

The viscosity of preparation reduces along with adding titanium dioxide.Owing to only have a preparation to contain titanium dioxide, this minimizing means that these two kinds of preparations represent two different phases of toothpaste.Therefore, behind the adding titanium dioxide, the rheology of each preparation does not match.

As shown in Figure 1, account for the titanium dioxide of this phase weight 0.5%, reduced the viscosity of said preparation by adding.As can be seen from Fig. 2, can replace 0.5% titanium dioxide to improve viscosity by adding 0.25% thickening property silicon dioxide.

Fig. 1

Fig. 2

Claims (15)

1. toothpaste, it comprises first and second compositionss, first and second compositionss comprise water, wetting agent and thickening agent, and second compositions is arranged in co-axial alignment in first compositions, first compositions is that the gel and second compositions are opaque, second compositions comprises the opacifier that accounts for the second composition weight y%, wherein y is 0.25 to 2, and the percentage by weight that the thickening agent that first compositions comprises exists than thickening agent in second compositions manys 0.2-2.0y%, with first composition weight meter, and wherein said thickening agent is selected from inorganic thickening property silicon dioxide, Irish moss glue, ι-carrageenin, gum tragacanth and polyethylene pyrrolidone, the consumption of thickening agent are 0.10 to 15% weight of toothpaste.

2. according to the toothpaste of claim 1, wherein opacifier is a titanium dioxide.

3. according to the toothpaste of claim 1 or 2, wherein y is 0.3 to 1.2.

4. according to the toothpaste of claim 1 or 2, wherein y is 0.4 to 0.7.

5. according to the toothpaste of claim 1 or 2, wherein y is 0.5.

6. according to the toothpaste of claim 1 or 2, wherein the thickening agent that comprises of first compositions is than the 0.3-1.0y% that manys that exists in second compositions, with first composition weight meter.

7. according to the toothpaste of claim 1 or 2, wherein the thickening agent that comprises of first compositions is than the 0.4-0.8y% that manys that exists in second compositions, with first composition weight meter.

8. according to the toothpaste of claim 1 or 2, wherein the thickening agent that comprises of first compositions is than the 0.45-0.55y% that manys that exists in second compositions, with first composition weight meter.

9. according to the toothpaste of claim 1 or 2, wherein the thickening agent that comprises of first compositions is than the 0.5y% that manys that exists in second compositions, with first composition weight meter.

10. according to the toothpaste of claim 1 or 2, wherein thickening agent is a thickening property silicon dioxide.

11. according to the toothpaste of claim 1 or 2, wherein first compositions does not have any this opacifier substantially.

12. according to the toothpaste of claim 1 or 2, wherein first compositions is visually clarifying gel.

13. according to the toothpaste of claim 1 or 2, wherein the difference of first and second compositionss only is the level of thickening agent, and the selection of coloring agent and spice.

14. according to the toothpaste of claim 1 or 2, the long-pending 5-25% of second composition constitutes wherein.

15. according to the toothpaste of claim 1, wherein the container of this toothpaste holds first and second compositionss as claimed in claim 1 or 2, this container comprises the body that an end curls, and comprises allocation component at the other end, and consumer is by this assembly extruding composition.