CN101111217A - Toothpaste composition - Google Patents

Abstract

The present invention relates to a toothpaste composition which includes an inner phase that is coaxially arranged in the external phase, the volume of the inner phase accounts for 60 to 99.9 percent of the composition volume, the external phase is gel rubber and the volume of the external phase accounts for 0.1 to 40 percent of the composition volume.

Description

Dentifrice composition

The present invention relates to a kind of oral cavity composition, comprise an inner phase of arranged in co-axial alignment in the foreign minister basically.

WO 99/01342 discloses the device that is used for multiple material is inserted container.This device comprises the mouth of pipe, second hollow member that this mouth of pipe has first hollow member and arranges in first hollow member.This mouth of pipe is designed to that multiple toothpaste phase extrudate is introduced one and is disposed in mutually in another toothpaste container in mutually.

Although prior art still needs to have the multiphase toothpaste composition of the visual effect of improvement.

The inventor finds can reach by the relative quantity of carefully setting every phase the visual effect of improvement.Therefore, in first aspect, the invention provides a kind of toothpaste according to claim 1.

Inner phase is arranged in co-axial alignment in the foreign minister.This is meant when dividing the longitudinal axis of this ribbon of timing to be in inner phase by toothpaste container.Similarly, the general longitudinal axis of this toothpaste (general longitudinal axis) is in inner phase when storing in toothpaste container.Should be appreciated that such arrangement is by judging on naked eyes rather than the mathematics.

When observing the cross section of distributing the ribbon terminal, inner phase can extend or until ribbon outer surface to the ribbon outer surface.Such extension can be radial, helical form or abstract, and when it is radial or helical form, can be regular or irregular.Radial extension for consumer's rule is most preferred.In addition, this core can be Any shape in cross section, for example star, square, triangle etc.The core of these shapings is subjected to the real welcome of young consumers.Yet most preferably inner phase does not comprise the core of extending and only ribbon being provided rule alternatively.This regular shape do not have fussy ornament and for product provides clean and tidy lines, and this has strengthened the impression that toothpaste aims to provide cleaning.

The visual effect of improving exists around the mode of inner phase basically with the foreign minister.In fact, on being dispensed to toothbrush after since the foreign minister will himself around inner phase parcel, the foreign minister may only can see in consumer.Therefore, the unfavorable visual effect of any inner phase existence can be offset by using the low-level relatively second other compositions that basically it is centered on.The dentifrice composition that has bigger formula range (formulation window) by use, formulator can be absorbed in the most effective prescription of realizing being used for inner phase, and needn't worry that it can have any disadvantageous visual effect, because these can only pass through second compositions, the foreign minister provides.So second compositions, the foreign minister provides the visual effect of the whole compositions of representative, for example glittering surface.

Preferably, inner phase is opaque.Visually with arbitrarily other compositions are compatible owing to there is no need to determine single composition, and composition whether fully dissolving do not matter yet, so this has just maximized the obtainable formula range of formulator.This provides extra benefit, because produced the silver color effect at two-phase interface.This is to the very attractive effect of consumer.

More preferably, inner phase comprises the Chalk as grinding agent.Chalk provides the abrasive system of improving, and it also can polish tooth when brushing teeth.In inner phase, use Chalk can prevent that also user from experiencing any disadvantageous taste relevant with Chalk.Chalk can be the natural whiting of winnofil or fine ground, and preferably it is the natural whiting with the fine ground of the less reaction of other compositions, and increases formula range thus once more.Preferably Chalk is with the first, and 5 to 70% amount of inner phase weight exists.

In a further preferred implementation, the foreign minister comprises abrasive silica.More preferably the foreign minister comprises the abrasive silica of low-refraction.It can be used as independent abrasive silica and uses, or with low-level other abrasive silica, for example unite use according to those of EP236070.The preferably apparent refractive index of low refractive index silica (R.I.) scope of using as grinding agent is the silicon dioxide of 1.41-1.47 in the present invention, and preferred 1.435-1.445 preferably has the average particle size of 5-15mm, and BET (nitrogen) surface area is 10 to 100m ²/ g, oil absorption are about 70-150cm ³/ 100g, but the abrasive silica of lower apparent refractive index also can be used.The representative instance of the low refractive index abrasive silicas (for example having the R.I. between 1.435 to 1.445) that is fit to is Tixosil 63 and 73, from Rhone Poulenc; Sident10 is from Degussa; Zeodent113 is from Zeofinn; Zeodent124 is from Huber; Sorbosil AC77 is from Crosfield Chemicals (have about 1.440 R.I.).The scope of silica volume generally is a 5-60% weight in the compositions, is generally 5-20% weight.

More preferably, the foreign minister is visually clarifying.The visually clarifying meaning is by the outside, and second can see inside, first phase mutually.

Arranged in co-axial alignment in the visually clarifying gel phase of first phase.This is meant by toothpaste container and divides the longitudinal axis of this ribbon of timing to be in inside, first phase.Similarly, the general longitudinal axis of this toothpaste is in the inside that wherein stores, first phase when storing in toothpaste container.Should be appreciated that such arrangement is by judging on naked eyes rather than the mathematics.

Preferably, inner first account for 80 to 99% of dentifrice composition volume mutually, preferred 90 to 95%.

About their principle (principle) component, i.e. thickening agent, activating agent, structural agent and grinding agent, first and second mutually can be identical or different.When first and second when mutually basic identical, their accessory constituent, for example pigment or spice can be different.Have two and visually clarifyingly also provide attractive compositions mutually for consumer.Inner phase comprises the mass efficient material, and the foreign minister provides the attractive outward appearance of the whole prescription of representative.For example, inner phase can comprise that clay is as structural agent.Clay does not provide vision attractive paste, therefore this inner phase will be able to be provided that the material of this visual attraction outward appearance forms second around.

In a preferred implementation, at least one is colored mutually.Preferably, the outside, visually clarifying is colored mutually.Preferred color comprises green, redness, orange, yellow, blue, gold and purple.This will give whole compositions all is colored impression, in fact but is not, inner phase only is opaque and colourless.

The method preparation of use standard is according to each phase of compositions of the present invention.Can be by detailed disclosed equipment among the WO 99/01342 for example, the coaxial mouth of pipe assembly that promptly is connected with standard device is extruded into it in dispense container.

In a most preferred embodiment, be 1500 00Pa.s to 250 000mPa.s in the viscosity that is had on 25 ℃ of Brookfield RV DV-1 viscometers that are being equipped with the Helipath support and when using spindle to measure with 5rpm according to each of compositions of the present invention.Such viscosity provides about being expressed into the optimum performance that the container neutralization is extruded from container by consumer.In this range of viscosities each in extrusion than stable physically many of other phases.

Can comprise the reagent that is selected from dental caries agent (anti carriesagents), brightener for tooth, anticalculus agent, halitosis agent, antigingivitis agent and composition thereof according to dentifrice composition of the present invention.

Dentifrice composition comprises composition further commonly used in the art, for example:

Antimicrobial, for example, chlorhexidine, the Sanguinarine extract, metronidazole, quaternary ammonium compound is cetylpyridinium chloride for example, and biguanide is chlorhexidine digluconate, hexetidine, octenidine, the western pyridine of Ah Lai for example; With halogenated bisphenol chemical compound for example 2,2 '-di-2-ethylhexylphosphine oxide-(4-chloro-6-bromophenol);

Antiinflammatory, for example ibuprofen, BTS-18322, aspirin, indomethacin etc.;

The dental caries agent, for example sodium fluoride and stannous fluoride, amine fluoride, sodium monofluorophosphate, sodium trimetaphosphate and casein;

Bacterial plaque buffer, for example carbamide, calcium lactate, calcium glycerophosphate and polyacrylic acid strontium;

Vitamin, for example vitamin A, C and E;

Plant extract;

Desensitizer, for example potassium citrate, potassium chloride, Soluble tartar., potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salt;

Anticalculus agent, for example alkali metal pyrophosphate, the polymer that contains hypophosphites, organic phosphonate and phosphoric acid citrate (phosphocitrates) etc.;

Biomolecule, for example bacteriocin, antibody, enzyme etc.;

Spice, for example Herba Menthae and Oleum menthae;

Proteinaceous material, for example collagen;

Antiseptic;

Opacifier;

Coloring agent;

The pH regulator agent;

Sweeting agent;

Pharmaceutical acceptable carrier, for example, starch, sucrose, water or water/pure system etc.;

Surfactant, for example anion, nonionic, cation and amphion or amphoteric surfactant;

The microgranule abrasive materials, for example silicon dioxide, aluminium oxide, calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, hydroxyapatite, trimetaphosphate, insoluble hexametaphosphate or the like, comprise agglomerant microgranule abrasive materials, content is generally 3 to 60% of oral care composition weight.Preferred grinding agent is Chalk and silicon dioxide, more preferably the natural whiting of fine ground.

Wetting agent, for example glycerol, sorbitol, propylene glycol, xylitol, lactose etc.;

Binding agent and thickening agent, for example sodium carboxymethyl cellulose, hydroxyethyl-cellulose (Natrosol ^), xanthan gum, arabic gum etc., and synthetic polymer, for example polyacrylate and carboxy vinyl polymer Carbopol for example ^

Also can comprise can the enhanced activity composition polymer sent of antimicrobial for example;

The buffer agent and the salt of buffering oral care composition pH and ionic strength; And

Other optional members that can comprise are bleachs for example, for example peroxide peroxide diphosphonic acid potassium (potassium peroxydiphosphate) for example; Effervescent system is the sodium bicarbonate/citric acid system for example, color change system, or the like.

Also can use liposome to improve sending of active component or stability.

In second aspect, the invention provides a kind of toothpaste container that comprises as described first and second phases of in tubular container, storing of first aspect present invention, this container comprises the corrugated body of an end, comprises allocation component at the other end, and consumer is by this assembly extruding composition.

Preferably, tubular container is transparent or semitransparent so that can see the inner phase among the foreign minister in the container.

With non-limiting example embodiments of the present invention are discussed now.

Embodiment

Composition	The first phase % (w/w)	The second phase % (w/w)
			Water	33	48
Sorbitol (70% aqueous solution)	15	23
			SMFP	0.76	0.76
Polyethylene Glycol (PEG 32)	0	2
			Thickening property silicon dioxide	5.0	10
Sodium carboxymethyl cellulose	0.6	0.9
			Sodium lauryl sulfate	2.5	1.8
Abrasive silica	-	10
			Chalk	40	-
Spice, glucide, CaGP, formalin, TSOP, TCN and pigment	Trace	Trace

First accounts for 85% of dentifrice composition volume mutually.

Claims (8)

1. a dentifrice composition comprises the inner phase of arranged in co-axial alignment in the foreign minister substantially, and inner phase accounts for the 60-99.9% of compositions volume, and the foreign minister accounts for the 0.1-40% of compositions volume.

2. according to the dentifrice composition of claim 1, wherein inner phase is opaque.

3. according to the dentifrice composition of claim 1 or 2, wherein inner phase comprises the Chalk as grinding agent.

4. according to the dentifrice composition of arbitrary aforementioned claim, wherein the foreign minister comprises gel.

5. according to the dentifrice composition of arbitrary aforementioned claim, wherein the foreign minister comprises abrasive silica.

6. according to the dentifrice composition of arbitrary aforementioned claim, wherein the foreign minister is visually clarifying.

7. according to the dentifrice composition of arbitrary aforementioned claim, wherein the foreign minister is colourless.

8. according to the dentifrice composition of arbitrary aforementioned claim, wherein the foreign minister accounts for the 0.1-5% of compositions volume.