CA2496233A1 - Methods and compositions for the generation of humanized mice - Google Patents
Methods and compositions for the generation of humanized mice Download PDFInfo
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- CA2496233A1 CA2496233A1 CA002496233A CA2496233A CA2496233A1 CA 2496233 A1 CA2496233 A1 CA 2496233A1 CA 002496233 A CA002496233 A CA 002496233A CA 2496233 A CA2496233 A CA 2496233A CA 2496233 A1 CA2496233 A1 CA 2496233A1
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| EP2245155A4 (en) * | 2007-12-10 | 2011-05-25 | Aliva Biopharmaceuticals Inc | METHODS FOR SEQUENTIALLY REPLACING A TARGETED AREA BY HOMOLOGOUS RECOMBINATION |
| KR20110020860A (ko) | 2008-05-23 | 2011-03-03 | 알리바 바이오파마수티컬스, 아이엔씨. | 유전자 삽입동물에서 단일 ｖｌ 도메인 항체를 생산하는 방법 |
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| US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
| EP2564695B1 (en) | 2009-07-08 | 2015-04-15 | Kymab Limited | Animal models and therapeutic molecules |
| PT3417701T (pt) * | 2009-10-06 | 2022-03-16 | Univ Yale | Ratinhos modificados geneticamente e enxerto |
| CA3006800C (en) | 2010-03-31 | 2022-10-04 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
| FI3375284T3 (fi) | 2011-02-15 | 2023-06-15 | Regeneron Pharma | Humanisoituja m-csf-hiiriä ja niiden käyttötapoja |
| CN106995822B (zh) | 2011-09-19 | 2021-06-29 | 科马布有限公司 | 定制供人类使用的抗体、可变结构域和链 |
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| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| KR102340059B1 (ko) | 2012-09-07 | 2021-12-17 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
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| FI3841877T3 (fi) | 2014-05-19 | 2023-12-01 | Regeneron Pharma | Ihmisen epo:a ilmentäviä geneettisesti muunneltuja hiiriä |
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| WO2018233608A1 (en) * | 2017-06-19 | 2018-12-27 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED TO CD28 HUMAN OR CHIMERIC |
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| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2090473A1 (en) * | 1990-08-29 | 1992-03-01 | Robert M. Kay | Homologous recombinatin in mammalian cells |
| DK0546073T3 (da) * | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) * | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) * | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5874299A (en) * | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DE4228162C1 (de) * | 1992-08-25 | 1994-01-13 | Rajewsky Klaus Dr | Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern |
| WO2001011951A1 (en) * | 1999-08-13 | 2001-02-22 | Kirin Beer Kabushiki Kaisha | Mouse having human cytochrome p450 transferred therein |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2295228T3 (es) * | 2000-11-30 | 2008-04-16 | Medarex, Inc. | Roedores transcromosomicos transgenicos para la preparacion de anticuerpos humanos. |
| AU2003257155A1 (en) * | 2002-08-02 | 2004-02-23 | The General Hospital Corporation | Methods for the production of cells and mammals with desired genetic modifications |
-
2003
- 2003-09-09 EP EP03770309A patent/EP1539946A4/en not_active Ceased
- 2003-09-09 CA CA002496233A patent/CA2496233A1/en not_active Abandoned
- 2003-09-09 AU AU2003278790A patent/AU2003278790A1/en not_active Abandoned
- 2003-09-09 JP JP2004534817A patent/JP2005537805A/ja active Pending
- 2003-09-09 US US10/659,034 patent/US20040128703A1/en not_active Abandoned
- 2003-09-09 WO PCT/US2003/028485 patent/WO2004022738A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004022738A8 (en) | 2004-05-21 |
| EP1539946A1 (en) | 2005-06-15 |
| US20040128703A1 (en) | 2004-07-01 |
| AU2003278790A1 (en) | 2004-03-29 |
| WO2004022738A1 (en) | 2004-03-18 |
| JP2005537805A (ja) | 2005-12-15 |
| EP1539946A4 (en) | 2006-03-15 |
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