CA2495617A1 - Determination et/ou regulation de conditions environnementales d'un reacteur - Google Patents

Determination et/ou regulation de conditions environnementales d'un reacteur Download PDF

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Publication number
CA2495617A1
CA2495617A1 CA002495617A CA2495617A CA2495617A1 CA 2495617 A1 CA2495617 A1 CA 2495617A1 CA 002495617 A CA002495617 A CA 002495617A CA 2495617 A CA2495617 A CA 2495617A CA 2495617 A1 CA2495617 A1 CA 2495617A1
Authority
CA
Canada
Prior art keywords
reaction site
chip
predetermined reaction
concentration
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002495617A
Other languages
English (en)
Inventor
Scott E. Miller
Gennady Malin
Howard B. Schreyer
Seth T. Rodgers
Andrey J. Zarur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioprocessors Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/457,049 external-priority patent/US20040058437A1/en
Priority claimed from US10/457,015 external-priority patent/US20040058407A1/en
Application filed by Individual filed Critical Individual
Publication of CA2495617A1 publication Critical patent/CA2495617A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Sustainable Development (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

De manière générale, la présente invention concerne des puces de réaction chimique, biologique et/ou biochimique et d'autres systèmes de réaction, tels que des systèmes à microréacteurs, ainsi que des systèmes et des procédés de fabrication et d'utilisation de ces dispositifs. Dans un aspect, une puce ou un autre système de réaction peut être conçu pour promouvoir la croissance cellulaire à l'intérieur de la puce ou du système. Dans certains modes de réalisation, les puces ou les autres systèmes de réaction de l'invention comprennent un ou plusieurs sites de réaction. Ces sites de réaction peuvent être très petits et présenter, par exemple, un volume inférieur à environ 1 ml. Dans un aspect de l'invention, une puce peut détecter, mesurer et/ou réguler un facteur environnemental, tel que la température, la pression, la concentration en CO¿2?, la concentration en O¿2?, l'humidité relative, le pH, etc., associé à un ou plusieurs sites de réaction. Pour ce faire, elle utilise un ou plusieurs détecteurs, actionneurs, processeurs et/ou systèmes de régulation. Dans un autre aspect, la présente invention concerne des matériaux et des systèmes permettant une régulation de l'humidité et/ou des gaz et pouvant être utilisés, par exemple, avec une puce. Ces matériaux peuvent présenter une haute perméabilité à l'oxygène et/ou une faible perméabilité à la vapeur d'eau. Dans un aspect supplémentaire, la présente invention concerne généralement des composants interagissant avec la lumière et pouvant être utilisés dans des puces et d'autres systèmes de réaction. Ces composants peuvent comprendre des guides d'ondes, des fibres optiques, des sources de lumière, des photodétecteurs, des éléments optiques, etc.
CA002495617A 2002-08-19 2003-08-19 Determination et/ou regulation de conditions environnementales d'un reacteur Abandoned CA2495617A1 (fr)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US22356202A 2002-08-19 2002-08-19
US10/223,562 2002-08-19
US40927302P 2002-09-09 2002-09-09
US60/409,273 2002-09-09
US45613303A 2003-06-05 2003-06-05
US45693403A 2003-06-05 2003-06-05
US45704803A 2003-06-05 2003-06-05
US10/457,048 2003-06-05
US10/456,133 2003-06-05
US10/457,049 US20040058437A1 (en) 2001-04-10 2003-06-05 Materials and reactor systems having humidity and gas control
US10/457,049 2003-06-05
US10/457,015 US20040058407A1 (en) 2001-04-10 2003-06-05 Reactor systems having a light-interacting component
US10/456,934 2003-06-05
US10/457,015 2003-06-05
PCT/US2003/025956 WO2004016727A1 (fr) 2002-08-19 2003-08-19 Determination et/ou regulation de conditions environnementales d'un reacteur

Publications (1)

Publication Number Publication Date
CA2495617A1 true CA2495617A1 (fr) 2004-02-26

Family

ID=31892403

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002495617A Abandoned CA2495617A1 (fr) 2002-08-19 2003-08-19 Determination et/ou regulation de conditions environnementales d'un reacteur
CA002496017A Abandoned CA2496017A1 (fr) 2002-08-19 2003-08-19 Architecture de microreacteur et procedes associes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002496017A Abandoned CA2496017A1 (fr) 2002-08-19 2003-08-19 Architecture de microreacteur et procedes associes

Country Status (5)

Country Link
EP (2) EP1530626A1 (fr)
JP (2) JP2005536233A (fr)
AU (3) AU2003272223A1 (fr)
CA (2) CA2495617A1 (fr)
WO (3) WO2004016729A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
GB0210809D0 (en) * 2002-05-11 2002-06-19 Univ Durham Reactor
US8158728B2 (en) 2004-02-13 2012-04-17 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
JP4664646B2 (ja) * 2004-10-20 2011-04-06 一般社団法人オンチップ・セロミクス・コンソーシアム 細胞培養用マイクロチャンバーおよび細胞構造構築法
CA2586400A1 (fr) * 2004-11-11 2006-05-18 Agency For Science, Technology And Research Dispositif de culture de cellules
CA2588753C (fr) 2004-12-03 2014-02-18 Cytonome, Inc. Cartouche unitaire pour traitement de particules
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
DE102005004075B4 (de) * 2005-01-28 2008-04-03 Umicore Ag & Co. Kg Keramischer Mikroreaktor
DE102006030068A1 (de) * 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
SG173398A1 (en) 2006-07-19 2011-08-29 Bionanomatrix Inc Nanonozzle device arrays: their preparation and use for macromolecular analysis
US7811359B2 (en) 2007-01-18 2010-10-12 General Electric Company Composite membrane for separation of carbon dioxide
JP2008194029A (ja) * 2007-01-19 2008-08-28 Tosoh Corp 細胞融合装置及びそれを用いた細胞融合方法
AU2008232616B2 (en) 2007-03-28 2014-08-07 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
JP4963437B2 (ja) * 2007-03-30 2012-06-27 京セラ株式会社 流路体、配線基板、流路形成配線基板、流路形成方法、流路体の製造方法、ならびに流路体キット
US8389277B2 (en) 2007-10-11 2013-03-05 Agency For Science, Technology And Research Forming cell structure with transient linker in cage
US20110081672A1 (en) * 2008-06-13 2011-04-07 Steen Kjaer Andersen Process control of biotechnological processes
JP5730762B2 (ja) 2008-06-30 2015-06-10 バイオナノ ジェノミックス、インク． 単一分子全ゲノム解析のための方法及び装置
CN102292454B (zh) 2008-11-18 2014-11-26 博纳基因技术有限公司 多核苷酸作图和测序
DE102014214077A1 (de) * 2014-07-18 2016-01-21 Hamilton Bonaduz Ag Laborbehälter, insbesondere Zellkulturbehälter, mit einer in das Behältervolumen hinein verlaufenden Gas-Ausgleichsleitung
EP3406707A1 (fr) * 2015-01-26 2018-11-28 Ube Industries, Ltd. Culture de cellules à long terme utilisant une membrane poreuse en polyimide et procédé de cryoconservation de cellules utilisant ladite membrane poreuse en polyimide
NL2020612B1 (en) 2017-12-22 2019-07-02 Illumina Inc Light detection devices with protective liner and methods of manufacturing same
CN109799012B (zh) * 2019-01-23 2021-01-22 河南工程学院 一种基于纤维素的类三明治结构压力传感器及其制备方法
CN118043667A (zh) * 2021-10-08 2024-05-14 菲利普莫里斯生产公司 周围介质中的生物活性剂的检测

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Publication number Priority date Publication date Assignee Title
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5800778A (en) * 1995-05-31 1998-09-01 Biomerieux Vitek, Inc. Sealant for sample holder
DE19753598C1 (de) * 1997-12-03 1999-07-01 Micronas Intermetall Gmbh Vorrichtung zum Messen physiologischer Parameter
JP2899701B1 (ja) * 1998-06-19 1999-06-02 工業技術院長 透過スイッチ型カーボン膜
GB9912641D0 (en) * 1999-05-28 1999-07-28 Ashby Scient Ltd Textured and porous silicone rubber
JP2001157879A (ja) * 1999-08-31 2001-06-12 Tadahiro Omi 水溶液のｐＨ制御の方法及びその装置
JP3200631B2 (ja) * 1999-09-08 2001-08-20 北陸先端科学技術大学院大学長 細胞の代謝活性に及ぼす影響を測定するためのバイオセンサー
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EP1309719B2 (fr) * 2000-08-14 2022-09-07 University of Maryland at Baltimore County Bioreacteur et procede biotechnologique
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Also Published As

Publication number Publication date
WO2004069983A2 (fr) 2004-08-19
WO2004016729A2 (fr) 2004-02-26
JP2006521786A (ja) 2006-09-28
WO2004069983A9 (fr) 2005-02-03
EP1530626A1 (fr) 2005-05-18
JP2005536233A (ja) 2005-12-02
AU2003272223A1 (en) 2004-03-03
AU2003265491A1 (en) 2004-03-03
CA2496017A1 (fr) 2004-08-19
WO2004069983A3 (fr) 2005-07-14
WO2004016729A3 (fr) 2005-06-30
WO2004016727A9 (fr) 2004-05-27
AU2003303303A1 (en) 2004-08-30
WO2004016727A1 (fr) 2004-02-26
WO2004016727B1 (fr) 2004-07-08
EP1567637A2 (fr) 2005-08-31
AU2003265491A8 (en) 2004-03-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued