CA2489259C - Polymeric micelle complexes of low molecular weight antitumor agents and styrene maleic acid copolymers - Google Patents
Polymeric micelle complexes of low molecular weight antitumor agents and styrene maleic acid copolymers Download PDFInfo
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- CA2489259C CA2489259C CA2489259A CA2489259A CA2489259C CA 2489259 C CA2489259 C CA 2489259C CA 2489259 A CA2489259 A CA 2489259A CA 2489259 A CA2489259 A CA 2489259A CA 2489259 C CA2489259 C CA 2489259C
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- pirarubicin
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- 238000000746 purification Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 125000004151 quinonyl group Chemical group 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003147852 | 2003-05-26 | ||
| JP2003-147852 | 2003-05-26 | ||
| PCT/JP2004/000993 WO2004103409A1 (ja) | 2003-05-26 | 2004-02-02 | 抗腫瘍剤及びその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2489259A1 CA2489259A1 (en) | 2004-12-02 |
| CA2489259C true CA2489259C (en) | 2011-08-30 |
Family
ID=33475378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2489259A Expired - Fee Related CA2489259C (en) | 2003-05-26 | 2004-02-02 | Polymeric micelle complexes of low molecular weight antitumor agents and styrene maleic acid copolymers |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7682630B2 (enExample) |
| EP (1) | EP1627645B1 (enExample) |
| JP (1) | JP4669393B2 (enExample) |
| CN (1) | CN1697663A (enExample) |
| AU (1) | AU2004241830B9 (enExample) |
| CA (1) | CA2489259C (enExample) |
| ES (1) | ES2642179T3 (enExample) |
| HU (1) | HUE035003T2 (enExample) |
| PT (1) | PT1627645T (enExample) |
| TW (1) | TW200505414A (enExample) |
| WO (1) | WO2004103409A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006238072A1 (en) * | 2005-04-18 | 2006-10-26 | Hiroshi Maeda | Polymeric pharmaceutical agent for treatment of cancer and process for production of the same |
| EP1926492B1 (en) * | 2005-09-12 | 2010-10-13 | BENDALE. N, Yogesh | Novel bio platinum, process for preparation, method of administration for anti-tumour treatment |
| FR2922452B1 (fr) * | 2007-10-19 | 2010-01-22 | Coatex Sas | Formulations de composes organoplatiniques en presence de polymeres associatifs, produits obtenus et leurs utilisations |
| JP2010013411A (ja) * | 2008-07-05 | 2010-01-21 | Hiroshi Maeda | 抗炎症剤 |
| ES2627026T3 (es) | 2011-09-05 | 2017-07-26 | Hiroshi Maeda | Sonda molecular fluorescente de tipo polímero |
| JP6083738B2 (ja) * | 2013-03-06 | 2017-02-22 | 公立大学法人大阪市立大学 | ホウ素中性子捕捉療法用組成物およびその製造方法 |
| WO2015088990A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3367921D1 (en) * | 1982-02-27 | 1987-01-15 | Kuraray Co | Neocarzinostatin complexes, a method for producing the same, and an antitumor agent containing said complexes as an active component |
| JPS58149903A (ja) * | 1982-02-27 | 1983-09-06 | Kuraray Co Ltd | ネオカルチノスタチン複合体の製造法 |
| JPS6075499A (ja) * | 1983-08-08 | 1985-04-27 | Kuraray Co Ltd | ネオカルチノスタチン誘導体及びその製造法 |
| JP2556865B2 (ja) * | 1986-09-19 | 1996-11-27 | 山之内製薬株式会社 | ネオカルチノスタチン誘導体の非注射投与用組成物 |
| US5281710A (en) * | 1990-08-01 | 1994-01-25 | The Scripps Research Institute | Dynemicin analogs: synthesis, methods of preparation and use |
| EP0914116B1 (en) * | 1996-05-22 | 2000-10-11 | Protarga Inc. | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
| GB0001481D0 (en) * | 2000-01-21 | 2000-03-15 | Theryte Ltd | System for delivering a medicament |
| KR100446101B1 (ko) | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
-
2004
- 2004-02-02 ES ES04707295.4T patent/ES2642179T3/es not_active Expired - Lifetime
- 2004-02-02 AU AU2004241830A patent/AU2004241830B9/en not_active Expired
- 2004-02-02 CN CNA2004800006708A patent/CN1697663A/zh active Pending
- 2004-02-02 PT PT47072954T patent/PT1627645T/pt unknown
- 2004-02-02 HU HUE04707295A patent/HUE035003T2/en unknown
- 2004-02-02 WO PCT/JP2004/000993 patent/WO2004103409A1/ja not_active Ceased
- 2004-02-02 EP EP04707295.4A patent/EP1627645B1/en not_active Expired - Lifetime
- 2004-02-02 CA CA2489259A patent/CA2489259C/en not_active Expired - Fee Related
- 2004-02-02 US US10/514,892 patent/US7682630B2/en not_active Expired - Fee Related
- 2004-02-02 JP JP2005506303A patent/JP4669393B2/ja not_active Expired - Fee Related
- 2004-03-15 TW TW093106868A patent/TW200505414A/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI332834B (enExample) | 2010-11-11 |
| JP4669393B2 (ja) | 2011-04-13 |
| CN1697663A (zh) | 2005-11-16 |
| WO2004103409A1 (ja) | 2004-12-02 |
| EP1627645A4 (en) | 2008-12-24 |
| TW200505414A (en) | 2005-02-16 |
| ES2642179T3 (es) | 2017-11-15 |
| AU2004241830B9 (en) | 2010-04-22 |
| JPWO2004103409A1 (ja) | 2006-07-20 |
| US7682630B2 (en) | 2010-03-23 |
| EP1627645B1 (en) | 2017-08-23 |
| AU2004241830B2 (en) | 2010-02-25 |
| HUE035003T2 (en) | 2018-05-02 |
| EP1627645A1 (en) | 2006-02-22 |
| US20050208136A1 (en) | 2005-09-22 |
| PT1627645T (pt) | 2017-11-23 |
| AU2004241830A1 (en) | 2004-12-02 |
| CA2489259A1 (en) | 2004-12-02 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20210202 |