CA2488348A1

CA2488348A1 - Long lasting natriuretic peptide derivatives

Long lasting natriuretic peptide derivatives Download PDF

Info

Publication number: CA2488348A1
Authority: CA; Canada
Prior art keywords: fmoc; arg; ser; gly; absent
Prior art date: 2002-07-31
Legal status : Abandoned

Application number

CA002488348A

Other languages

English (en)

French (fr)

Inventor

Dominique P. Bridon

Peter Bakis

Julie Carette

Roger Leger

Martin Robitaille

France Leclaire

Current Assignee

ConjuChem Biotechnologies Inc

Original Assignee

Individual

Priority date

2002-07-31

Filing date

2003-07-29

Publication date

2004-02-05

2003-07-29 Application filed by Individual filed Critical Individual

2004-02-05 Publication of CA2488348A1 publication Critical patent/CA2488348A1/en

Status Abandoned legal-status Critical Current

Links

108020001621 Natriuretic Peptide Proteins 0.000 title claims abstract description 204
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239000000692 natriuretic peptide Substances 0.000 title claims abstract description 114
230000005923 long-lasting effect Effects 0.000 title abstract description 5
238000000034 method Methods 0.000 claims abstract description 51
239000012503 blood component Substances 0.000 claims abstract description 47
206010019280 Heart failures Diseases 0.000 claims abstract description 33
206010007559 Cardiac failure congestive Diseases 0.000 claims abstract description 27
238000001727 in vivo Methods 0.000 claims abstract description 13
-1 methyl amino, hydroxyl ethyl Chemical group 0.000 claims description 261
108090000765 processed proteins & peptides Proteins 0.000 claims description 148
150000001413 amino acids Chemical class 0.000 claims description 112
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims description 89
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KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 63
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical group NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims description 62
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical group OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims description 52
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CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 44
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical group OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 43
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208000006673 asthma Diseases 0.000 claims description 8
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