CA2486345A1 - Proteines avec domaines de repetition de bacterie, type ig (big), dans l'espece leptospira - Google Patents
Proteines avec domaines de repetition de bacterie, type ig (big), dans l'espece leptospira Download PDFInfo
- Publication number
- CA2486345A1 CA2486345A1 CA002486345A CA2486345A CA2486345A1 CA 2486345 A1 CA2486345 A1 CA 2486345A1 CA 002486345 A CA002486345 A CA 002486345A CA 2486345 A CA2486345 A CA 2486345A CA 2486345 A1 CA2486345 A1 CA 2486345A1
- Authority
- CA
- Canada
- Prior art keywords
- functionally equivalent
- equivalent sequences
- polypeptides
- seq
- bigl1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000589902 Leptospira Species 0.000 title claims abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000003252 repetitive effect Effects 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 claims abstract 2
- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 102000040430 polynucleotide Human genes 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 10
- 230000001717 pathogenic effect Effects 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 241000589970 Spirochaetales Species 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 210000003850 cellular structure Anatomy 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 2
- 241000589968 Borrelia Species 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 241000589886 Treponema Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
Abstract
L'invention porte sur trois molécules d'ADN isolées qui codent pour les protéines BigL1, BigL2 et BigL3 dans la bactérie Leptospira, ces protéines ayant des domaines de répétition de bactérie, type Ig, et sur leur utilisation dans des applications diagnostiques, thérapeutiques et de vaccination. Selon cette invention, les molécules isolées codant pour les protéines BigL1, BigL2 et BigL3 sont utilisées dans le diagnostic et la prévention d'infection par l'espèce Leptospira qui est capable de générer des maladies chez l'homme et autres mammifères, y compris celles à caractère vétérinaire.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/147,299 US20040058323A1 (en) | 2002-05-17 | 2002-05-17 | Proteins with repetitive bacterial-Ig-like (big) domains present in leptospira species |
US10/147,299 | 2002-05-17 | ||
PCT/BR2002/000072 WO2003098214A1 (fr) | 2002-05-17 | 2002-05-20 | Proteines avec domaines de repetition de bacterie, type ig (big), dans l'espece leptospira |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2486345A1 true CA2486345A1 (fr) | 2003-11-27 |
CA2486345C CA2486345C (fr) | 2012-08-14 |
Family
ID=34195214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2486345A Expired - Fee Related CA2486345C (fr) | 2002-05-17 | 2002-05-20 | Proteines avec domaines de repetition de bacterie, type ig (big), dans l'espece leptospira |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1514104B1 (fr) |
AU (1) | AU2002308453B2 (fr) |
CA (1) | CA2486345C (fr) |
DE (1) | DE60222812T2 (fr) |
WO (1) | WO2003098214A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2501939C (fr) | 2002-10-10 | 2013-10-08 | Cornell Research Foundation, Inc. | Nouvelles proteines immunogenes de leptospira |
US20050089533A1 (en) * | 2003-01-29 | 2005-04-28 | Joseph Frantz | Canine vaccines against Bordetella bronchiseptica |
BRPI0505529A (pt) | 2005-12-19 | 2007-09-25 | Fundacao Oswaldo Cruz | proteìnas liga e ligb (leptospiral ig-like(lig) domains) para vacinação e diagnóstico |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091301A (en) * | 1989-03-22 | 1992-02-25 | The Unites States Of America As Represented By The Secretary Of Agriculture | Diagnostic and epidemiological nucleic acid probe for bovine leptospirosis |
IL121820A0 (en) * | 1996-01-22 | 1998-02-22 | Univ California | Leptospiral outer membrane proteins |
-
2002
- 2002-05-20 AU AU2002308453A patent/AU2002308453B2/en not_active Ceased
- 2002-05-20 EP EP02807433A patent/EP1514104B1/fr not_active Expired - Lifetime
- 2002-05-20 CA CA2486345A patent/CA2486345C/fr not_active Expired - Fee Related
- 2002-05-20 DE DE60222812T patent/DE60222812T2/de not_active Expired - Lifetime
- 2002-05-20 WO PCT/BR2002/000072 patent/WO2003098214A1/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1514104A1 (fr) | 2005-03-16 |
DE60222812T2 (de) | 2008-08-28 |
AU2002308453B2 (en) | 2009-12-03 |
WO2003098214A1 (fr) | 2003-11-27 |
DE60222812D1 (de) | 2007-11-15 |
EP1514104A4 (fr) | 2005-12-07 |
EP1514104B1 (fr) | 2007-10-03 |
CA2486345C (fr) | 2012-08-14 |
AU2002308453A1 (en) | 2003-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDC | Discontinued application reinstated | ||
MKLA | Lapsed |
Effective date: 20200831 |