CA2484769A1 - Spectrometre de masse - Google Patents
Spectrometre de masse Download PDFInfo
- Publication number
- CA2484769A1 CA2484769A1 CA 2484769 CA2484769A CA2484769A1 CA 2484769 A1 CA2484769 A1 CA 2484769A1 CA 2484769 CA2484769 CA 2484769 CA 2484769 A CA2484769 A CA 2484769A CA 2484769 A1 CA2484769 A1 CA 2484769A1
- Authority
- CA
- Canada
- Prior art keywords
- mass
- ion
- potential
- flight
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 893
- 239000012634 fragment Substances 0.000 claims abstract description 302
- 238000000034 method Methods 0.000 claims abstract description 107
- 230000003595 spectral effect Effects 0.000 claims abstract description 83
- 230000005684 electric field Effects 0.000 claims description 86
- 238000001819 mass spectrum Methods 0.000 claims description 72
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 14
- 238000011144 upstream manufacturing Methods 0.000 claims description 9
- 238000003795 desorption Methods 0.000 claims description 6
- 238000010265 fast atom bombardment Methods 0.000 claims description 6
- 238000009616 inductively coupled plasma Methods 0.000 claims description 6
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 5
- 238000001698 laser desorption ionisation Methods 0.000 claims description 5
- 238000004949 mass spectrometry Methods 0.000 claims description 5
- 238000000451 chemical ionisation Methods 0.000 claims description 4
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 3
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims description 3
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 2
- 238000001228 spectrum Methods 0.000 description 43
- 238000013467 fragmentation Methods 0.000 description 31
- 238000006062 fragmentation reaction Methods 0.000 description 31
- 108090000765 processed proteins & peptides Proteins 0.000 description 27
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 24
- 241000894007 species Species 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 8
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 7
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 7
- 229960000258 corticotropin Drugs 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 5
- 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 description 4
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 description 4
- 101000780443 Homo sapiens Alcohol dehydrogenase 1A Proteins 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- FQVLRGLGWNWPSS-BXBUPLCLSA-N (4r,7s,10s,13s,16r)-16-acetamido-13-(1h-imidazol-5-ylmethyl)-10-methyl-6,9,12,15-tetraoxo-7-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide Chemical compound N1C(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CC1=CN=CN1 FQVLRGLGWNWPSS-BXBUPLCLSA-N 0.000 description 3
- 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 description 3
- 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000002542 parent ion scan Methods 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 102000015427 Angiotensins Human genes 0.000 description 1
- 108010064733 Angiotensins Proteins 0.000 description 1
- 241000370685 Arge Species 0.000 description 1
- 240000008100 Brassica rapa Species 0.000 description 1
- 241000448280 Elates Species 0.000 description 1
- 244000287680 Garcinia dulcis Species 0.000 description 1
- 101150072835 MPST gene Proteins 0.000 description 1
- 241000353097 Molva molva Species 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- WOZQBERUBLYCEG-UHFFFAOYSA-N SWEP Chemical compound COC(=O)NC1=CC=C(Cl)C(Cl)=C1 WOZQBERUBLYCEG-UHFFFAOYSA-N 0.000 description 1
- 102400000096 Substance P Human genes 0.000 description 1
- 101800003906 Substance P Proteins 0.000 description 1
- 241000962283 Turdus iliacus Species 0.000 description 1
- RRZFQNYMUQPMHE-HYEGCIPRSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate;(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C.CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 RRZFQNYMUQPMHE-HYEGCIPRSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000003323 beak Anatomy 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- KAATUXNTWXVJKI-UHFFFAOYSA-N cypermethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-UHFFFAOYSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000010006 flight Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000000955 peptide mass fingerprinting Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 238000001004 secondary ion mass spectrometry Methods 0.000 description 1
- 239000011163 secondary particle Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/405—Time-of-flight spectrometers characterised by the reflectron, e.g. curved field, electrode shapes
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0324054A GB0324054D0 (en) | 2003-10-14 | 2003-10-14 | Mass spectrometer |
| GBGB0324054.6 | 2003-10-14 | ||
| GB0404186A GB0404186D0 (en) | 2004-02-25 | 2004-02-25 | Mass spectrometer |
| GBGB0404186.9 | 2004-02-25 | ||
| GB0406601A GB0406601D0 (en) | 2003-10-14 | 2004-03-24 | Mass spectrometer |
| GBGB0406601.5 | 2004-03-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2484769A1 true CA2484769A1 (fr) | 2005-04-14 |
| CA2484769C CA2484769C (fr) | 2013-06-04 |
Family
ID=33479449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2484769A Expired - Fee Related CA2484769C (fr) | 2003-10-14 | 2004-10-14 | Spectrometre de masse |
| CA 2484755 Withdrawn CA2484755A1 (fr) | 2003-10-14 | 2004-10-14 | Spectrometre de masse |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2484755 Withdrawn CA2484755A1 (fr) | 2003-10-14 | 2004-10-14 | Spectrometre de masse |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4928724B2 (fr) |
| CA (2) | CA2484769C (fr) |
| DE (2) | DE102004049918B4 (fr) |
| GB (1) | GB2407206C (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024054960A1 (fr) * | 2022-09-09 | 2024-03-14 | The Trustees Of Indiana University | Procédé de commande d'un dispositif multipolaire pour réduire l'omission de sortie de particules chargées à partir d'une analyse en aval |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2470599B (en) * | 2009-05-29 | 2014-04-02 | Thermo Fisher Scient Bremen | Charged particle analysers and methods of separating charged particles |
| GB201208961D0 (en) * | 2012-05-18 | 2012-07-04 | Micromass Ltd | 2 dimensional MSMS |
| US11244817B2 (en) * | 2018-05-31 | 2022-02-08 | Shimadzu Corporation | Analytical device, analysis method and program |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3920566A1 (de) * | 1989-06-23 | 1991-01-10 | Bruker Franzen Analytik Gmbh | Ms-ms-flugzeit-massenspektrometer |
| US5160840A (en) * | 1991-10-25 | 1992-11-03 | Vestal Marvin L | Time-of-flight analyzer and method |
| US5464985A (en) * | 1993-10-01 | 1995-11-07 | The Johns Hopkins University | Non-linear field reflectron |
| DE19544808C2 (de) * | 1995-12-01 | 2000-05-11 | Bruker Daltonik Gmbh | Verfahren zur Untersuchung der Struktur von Ionen in einem Flugzeitmassenspektrometer |
| US5814813A (en) * | 1996-07-08 | 1998-09-29 | The Johns Hopkins University | End cap reflection for a time-of-flight mass spectrometer and method of using the same |
| JP3785695B2 (ja) * | 1996-09-11 | 2006-06-14 | 株式会社島津製作所 | ペプチドのアミノ酸配列決定方法 |
| WO1999027560A2 (fr) * | 1997-11-24 | 1999-06-03 | The Johns-Hopkins University | Procede et appareil permettant de corriger la vitesse initiale d'ions dans un spectrometre de masse a temps de vol a reflectron |
| JP3472130B2 (ja) * | 1998-03-27 | 2003-12-02 | 日本電子株式会社 | 飛行時間質量分析計 |
| AUPQ213199A0 (en) * | 1999-08-10 | 1999-09-02 | Gbc Scientific Equipment Pty Ltd | A time of flight mass spectrometer including an orthogonal accelerator |
| US6841773B2 (en) * | 2000-05-30 | 2005-01-11 | The Johns Hopkins University | Portable time-of-flight mass spectrometer system |
| GB0021901D0 (en) * | 2000-09-06 | 2000-10-25 | Kratos Analytical Ltd | Calibration method |
| US7074570B2 (en) * | 2001-05-23 | 2006-07-11 | Ge Healthcare Bio-Sciences Ab | Peptide fragmentation |
-
2004
- 2004-10-13 DE DE200410049918 patent/DE102004049918B4/de not_active Expired - Fee Related
- 2004-10-13 JP JP2004299297A patent/JP4928724B2/ja not_active Expired - Fee Related
- 2004-10-13 DE DE200420015862 patent/DE202004015862U1/de not_active Expired - Lifetime
- 2004-10-13 GB GB0422770A patent/GB2407206C/en not_active Expired - Fee Related
- 2004-10-14 CA CA2484769A patent/CA2484769C/fr not_active Expired - Fee Related
- 2004-10-14 CA CA 2484755 patent/CA2484755A1/fr not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024054960A1 (fr) * | 2022-09-09 | 2024-03-14 | The Trustees Of Indiana University | Procédé de commande d'un dispositif multipolaire pour réduire l'omission de sortie de particules chargées à partir d'une analyse en aval |
Also Published As
| Publication number | Publication date |
|---|---|
| DE102004049918B4 (de) | 2010-11-25 |
| JP2005166639A (ja) | 2005-06-23 |
| DE102004049918A1 (de) | 2005-06-02 |
| CA2484769C (fr) | 2013-06-04 |
| GB0422770D0 (en) | 2004-11-17 |
| GB2407206A (en) | 2005-04-20 |
| JP4928724B2 (ja) | 2012-05-09 |
| CA2484755A1 (fr) | 2005-04-14 |
| GB2407206C (en) | 2007-02-27 |
| DE202004015862U1 (de) | 2005-02-24 |
| GB2407206B (en) | 2005-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20201014 |