CA2484398C - Method for reducing pain using oncolytic viruses - Google Patents

Method for reducing pain using oncolytic viruses Download PDF

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Publication number
CA2484398C
CA2484398C CA2484398A CA2484398A CA2484398C CA 2484398 C CA2484398 C CA 2484398C CA 2484398 A CA2484398 A CA 2484398A CA 2484398 A CA2484398 A CA 2484398A CA 2484398 C CA2484398 C CA 2484398C
Authority
CA
Canada
Prior art keywords
reovirus
virus
pain
analgesic
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2484398A
Other languages
English (en)
French (fr)
Other versions
CA2484398A1 (en
Inventor
Donald Morris
Matthew C. Coffey
Bradley G. Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncolytics Biotech Inc
Original Assignee
Oncolytics Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncolytics Biotech Inc filed Critical Oncolytics Biotech Inc
Publication of CA2484398A1 publication Critical patent/CA2484398A1/en
Application granted granted Critical
Publication of CA2484398C publication Critical patent/CA2484398C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/765Reovirus; Rotavirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011Details
    • C12N2720/12011Reoviridae
    • C12N2720/12211Orthoreovirus, e.g. mammalian orthoreovirus
    • C12N2720/12232Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2484398A 2002-05-09 2003-05-07 Method for reducing pain using oncolytic viruses Expired - Lifetime CA2484398C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37867502P 2002-05-09 2002-05-09
US60/378,675 2002-05-09
US44317703P 2003-01-29 2003-01-29
US60/443,177 2003-01-29
PCT/CA2003/000674 WO2003094938A1 (en) 2002-05-09 2003-05-07 Method for reducing pain using oncolytic viruses

Publications (2)

Publication Number Publication Date
CA2484398A1 CA2484398A1 (en) 2003-11-20
CA2484398C true CA2484398C (en) 2014-01-21

Family

ID=29423642

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2484398A Expired - Lifetime CA2484398C (en) 2002-05-09 2003-05-07 Method for reducing pain using oncolytic viruses

Country Status (19)

Country Link
US (2) US20040091458A1 (enExample)
EP (1) EP1505992B1 (enExample)
JP (1) JP5241059B2 (enExample)
AR (1) AR039986A1 (enExample)
AT (1) ATE404213T1 (enExample)
AU (1) AU2003229431B8 (enExample)
BR (1) BR0309825A (enExample)
CA (1) CA2484398C (enExample)
DE (2) DE03722131T1 (enExample)
DK (1) DK1505992T3 (enExample)
ES (1) ES2239928T3 (enExample)
IL (1) IL164695A (enExample)
MX (1) MXPA04011007A (enExample)
NZ (1) NZ536102A (enExample)
PT (1) PT1505992E (enExample)
SI (1) SI1505992T1 (enExample)
TR (1) TR200501460T3 (enExample)
TW (1) TWI316405B (enExample)
WO (1) WO2003094938A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
AU2002953436A0 (en) 2002-12-18 2003-01-09 The University Of Newcastle Research Associates Limited A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
US10260049B2 (en) 2005-08-01 2019-04-16 Virocure, Inc. Attenuated reovirus
US10668119B2 (en) 2005-08-01 2020-06-02 Virocure, Inc. Attenuated reovirus
US10369171B2 (en) 2007-03-13 2019-08-06 Virocure, Inc. Attenuated reoviruses for selection of cell populations
WO2008144067A1 (en) * 2007-05-21 2008-11-27 Board Of Regents, University Of Texas System Methods and compositions for treatment of cancer using oncolytic rsv activity
US8450106B2 (en) * 2007-10-17 2013-05-28 The Ohio State University Research Foundation Oncolytic virus
MX339014B (es) * 2008-05-27 2016-05-09 Oncolytics Biotech Inc Modulacion de presion intersticial y suministro y distribucion viral oncolitica.
KR20100054358A (ko) * 2008-11-14 2010-05-25 김재은 스틱 연고
AU2010242748B2 (en) * 2009-05-01 2015-07-23 Adare Pharmaceuticals, Inc. Orally disintegrating tablet compositions comprising combinations of high and low-dose drugs
EP2383577A1 (en) * 2010-04-30 2011-11-02 Deutsches Krebsforschungszentrum Diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy
CA2990133A1 (en) 2015-06-19 2017-03-09 Sillajen, Inc. Compositions and methods for viral embolization
AU2017221592A1 (en) 2016-02-16 2018-10-04 Osaka University Pharmaceutical composition for use in treating fibrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US6136307A (en) * 1997-08-13 2000-10-24 Oncolytics Biotech Inc. Reovirus for the treatment of cellular proliferative disorders
US6110461A (en) * 1997-08-13 2000-08-29 Oncolytics Biotech Inc. Reovirus for the treatment of neoplasia
NZ518945A (en) * 1997-10-09 2007-03-30 Wellstat Biologics Corp Treatment of neoplasms with viruses
US6428968B1 (en) * 1999-03-15 2002-08-06 The Trustees Of The University Of Pennsylvania Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject
TWI289158B (en) * 2000-08-10 2007-11-01 Oncolytics Biotech Inc Method of producing infectious reovirus

Also Published As

Publication number Publication date
EP1505992A1 (en) 2005-02-16
NZ536102A (en) 2008-01-31
BR0309825A (pt) 2005-03-01
DE03722131T1 (de) 2005-09-15
ATE404213T1 (de) 2008-08-15
AU2003229431B8 (en) 2009-07-02
AU2003229431A1 (en) 2003-11-11
US20040091458A1 (en) 2004-05-13
EP1505992B1 (en) 2008-08-13
JP2005526124A (ja) 2005-09-02
PT1505992E (pt) 2008-10-06
AR039986A1 (es) 2005-03-09
WO2003094938A1 (en) 2003-11-20
DE60322885D1 (de) 2008-09-25
ES2239928T1 (es) 2005-10-16
IL164695A0 (en) 2005-12-18
IL164695A (en) 2010-12-30
SI1505992T1 (sl) 2009-02-28
HK1070565A1 (en) 2005-06-24
TW200402305A (en) 2004-02-16
JP5241059B2 (ja) 2013-07-17
CA2484398A1 (en) 2003-11-20
AU2003229431B2 (en) 2008-01-17
TWI316405B (en) 2009-11-01
DK1505992T3 (da) 2008-10-06
TR200501460T3 (tr) 2005-06-21
US20080081032A1 (en) 2008-04-03
ES2239928T3 (es) 2009-02-16
MXPA04011007A (es) 2005-02-14

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Effective date: 20230508