CA2474031A1 - Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c - Google Patents
Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c Download PDFInfo
- Publication number
- CA2474031A1 CA2474031A1 CA002474031A CA2474031A CA2474031A1 CA 2474031 A1 CA2474031 A1 CA 2474031A1 CA 002474031 A CA002474031 A CA 002474031A CA 2474031 A CA2474031 A CA 2474031A CA 2474031 A1 CA2474031 A1 CA 2474031A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- butyl
- hydroxy
- cyclopentyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés représentés par la formule (I). Dans la formule, R?1¿ représente un dérivé hydroxyle ou sulfonamide; R?2¿ représente t-butyle ou CH¿2?-C(CH¿3?)¿3? ou CH¿2?-cyclopentyle; R¿3? représente t-butyle ou cyclohexyle et R?4¿ représente cyclobutyle, cyclopentyle ou cyclohexyle. Ces composés ou un sel pharmaceutiquement acceptable de ces derniers sont utiles en tant qu'inhibiteurs de la protéase de protéines non structurelles NS3 du virus de l'hépatite C (VHC). Formule (I)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2474031A CA2474031C (fr) | 2002-02-01 | 2003-01-24 | Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002369970A CA2369970A1 (fr) | 2002-02-01 | 2002-02-01 | Tri-peptides inhibiteur de l'hepatite c |
CA2,369,970 | 2002-02-01 | ||
PCT/CA2003/000091 WO2003064416A1 (fr) | 2002-02-01 | 2003-01-24 | Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c |
CA2474031A CA2474031C (fr) | 2002-02-01 | 2003-01-24 | Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2474031A1 true CA2474031A1 (fr) | 2003-08-07 |
CA2474031C CA2474031C (fr) | 2010-08-24 |
Family
ID=32991606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2474031A Expired - Fee Related CA2474031C (fr) | 2002-02-01 | 2003-01-24 | Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2474031C (fr) |
-
2003
- 2003-01-24 CA CA2474031A patent/CA2474031C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2474031C (fr) | 2010-08-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150126 |