CA2474031C - Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c - Google Patents

Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c Download PDF

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Publication number
CA2474031C
CA2474031C CA2474031A CA2474031A CA2474031C CA 2474031 C CA2474031 C CA 2474031C CA 2474031 A CA2474031 A CA 2474031A CA 2474031 A CA2474031 A CA 2474031A CA 2474031 C CA2474031 C CA 2474031C
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CA
Canada
Prior art keywords
compound
formula
hcv
butyl
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2474031A
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English (en)
Other versions
CA2474031A1 (fr
Inventor
Montse Llinas-Brunet
Murray D. Bailey
Elise Ghiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002369970A external-priority patent/CA2369970A1/fr
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to CA2474031A priority Critical patent/CA2474031C/fr
Publication of CA2474031A1 publication Critical patent/CA2474031A1/fr
Application granted granted Critical
Publication of CA2474031C publication Critical patent/CA2474031C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés représentés par la formule (I). Dans la formule, R?1¿ représente un dérivé hydroxyle ou sulfonamide; R?2¿ représente t-butyle ou CH¿2?-C(CH¿3?)¿3? ou CH¿2?-cyclopentyle; R¿3? représente t-butyle ou cyclohexyle et R?4¿ représente cyclobutyle, cyclopentyle ou cyclohexyle. Ces composés ou un sel pharmaceutiquement acceptable de ces derniers sont utiles en tant qu'inhibiteurs de la protéase de protéines non structurelles NS3 du virus de l'hépatite C (VHC). Formule (I)
CA2474031A 2002-02-01 2003-01-24 Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c Expired - Fee Related CA2474031C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2474031A CA2474031C (fr) 2002-02-01 2003-01-24 Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA002369970A CA2369970A1 (fr) 2002-02-01 2002-02-01 Tri-peptides inhibiteur de l'hepatite c
CA2,369,970 2002-02-01
PCT/CA2003/000091 WO2003064416A1 (fr) 2002-02-01 2003-01-24 Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c
CA2474031A CA2474031C (fr) 2002-02-01 2003-01-24 Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c

Publications (2)

Publication Number Publication Date
CA2474031A1 CA2474031A1 (fr) 2003-08-07
CA2474031C true CA2474031C (fr) 2010-08-24

Family

ID=32991606

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2474031A Expired - Fee Related CA2474031C (fr) 2002-02-01 2003-01-24 Tripeptides heterocycliques utiles en tant qu'inhibiteurs de l'hepatite c

Country Status (1)

Country Link
CA (1) CA2474031C (fr)

Also Published As

Publication number Publication date
CA2474031A1 (fr) 2003-08-07

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20150126