CA2465247C - Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases - Google Patents

Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases Download PDF

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Publication number
CA2465247C
CA2465247C CA2465247A CA2465247A CA2465247C CA 2465247 C CA2465247 C CA 2465247C CA 2465247 A CA2465247 A CA 2465247A CA 2465247 A CA2465247 A CA 2465247A CA 2465247 C CA2465247 C CA 2465247C
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Canada
Prior art keywords
benzoimidazol
pyrazol
carboxylic acid
dimethyl
amide
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Expired - Fee Related
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CA2465247A
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English (en)
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CA2465247A1 (fr
Inventor
Michael Louis Edwards
Paul Joseph Cox
Shelley Amendola
Stephanie Daniele Deprets
Timothy Alan Gillespy
Christopher David Edlin
Andrew David Morley
Charles J. Gardner
Brian Pedgrift
Herve Bouchard
Didier Babin
Laurence Gauzy
Alain Le Brun
Tahir Nedeem Majid
John C. Reader
Lloyd J. Payne
Nawaz M. Khan
Michael Cherry
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Aventis Pharmaceuticals Inc
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Aventis Pharmaceuticals Inc
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Priority claimed from FR0113868A external-priority patent/FR2831537B1/fr
Priority claimed from GB0206893A external-priority patent/GB0206893D0/en
Priority claimed from GB0206895A external-priority patent/GB0206895D0/en
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of CA2465247A1 publication Critical patent/CA2465247A1/fr
Application granted granted Critical
Publication of CA2465247C publication Critical patent/CA2465247C/fr
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

L'invention concerne des composés physiologiquement actifs représentés par la formule générale (Ix), des compositions qui renferment ces composés, leurs promédicaments, des sels ou solvates de ces composés acceptables sur le plan pharmaceutique et leurs promédicaments, ainsi que de nouveaux médicaments entrant dans le champ d'application de la formule (Ix) et des procédés pour leur préparation. Ces composés et compositions possèdent des propriétés pharmaceutiques intéressantes, notamment la capacité d'inhiber les kinases.
CA2465247A 2001-10-26 2002-10-24 Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases Expired - Fee Related CA2465247C (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
FR0113868A FR2831537B1 (fr) 2001-10-26 2001-10-26 Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation
FR01/13868 2001-10-26
GB0206893A GB0206893D0 (en) 2002-03-22 2002-03-22 Chemical compounds
GB0206895A GB0206895D0 (en) 2002-03-22 2002-03-22 Chemical compounds
GB0206893.0 2002-03-22
GB0206895.5 2002-03-22
US39506002P 2002-07-11 2002-07-11
US39515102P 2002-07-11 2002-07-11
US60/395,060 2002-07-11
US60/395,151 2002-07-11
PCT/GB2002/004763 WO2003035065A1 (fr) 2001-10-26 2002-10-24 Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases

Publications (2)

Publication Number Publication Date
CA2465247A1 CA2465247A1 (fr) 2003-05-01
CA2465247C true CA2465247C (fr) 2010-05-18

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CA2465247A Expired - Fee Related CA2465247C (fr) 2001-10-26 2002-10-24 Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases

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EP (1) EP1441725A1 (fr)
JP (1) JP5039268B2 (fr)
AU (1) AU2002334217B2 (fr)
BR (1) BR0213562A (fr)
CA (1) CA2465247C (fr)
IL (1) IL161576A0 (fr)
MX (1) MXPA04003954A (fr)
UY (1) UY27516A1 (fr)
WO (1) WO2003035065A1 (fr)

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AU2003246972A1 (en) 2002-08-06 2004-02-23 Astrazeneca Ab Condensed pyridines and pyrimidines with tie2 (tek) activity
US7309701B2 (en) 2002-11-19 2007-12-18 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
US7462613B2 (en) 2002-11-19 2008-12-09 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
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GB0315657D0 (en) * 2003-07-03 2003-08-13 Astex Technology Ltd Pharmaceutical compounds
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EP1441725A1 (fr) 2004-08-04
CA2465247A1 (fr) 2003-05-01
MXPA04003954A (es) 2004-11-29
WO2003035065A1 (fr) 2003-05-01
AU2002334217B2 (en) 2008-07-03
JP5039268B2 (ja) 2012-10-03
UY27516A1 (es) 2003-04-30

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