CA2459348C - Anticorps au recepteur p2x7 non fonctionnel, diagnostic et traitement de cancers et d'autres conditions - Google Patents

Anticorps au recepteur p2x7 non fonctionnel, diagnostic et traitement de cancers et d'autres conditions Download PDF

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Publication number
CA2459348C
CA2459348C CA2459348A CA2459348A CA2459348C CA 2459348 C CA2459348 C CA 2459348C CA 2459348 A CA2459348 A CA 2459348A CA 2459348 A CA2459348 A CA 2459348A CA 2459348 C CA2459348 C CA 2459348C
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CA
Canada
Prior art keywords
functional
receptors
antibody
cells
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2459348A
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English (en)
Other versions
CA2459348A1 (fr
Inventor
Angus Gidley-Baird
Julian Alexander Barden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosceptre International Ltd
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Biosceptre International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR7431A external-priority patent/AUPR743101A0/en
Priority claimed from AUPR7430A external-priority patent/AUPR743001A0/en
Priority claimed from PCT/AU2002/000061 external-priority patent/WO2002057306A1/fr
Application filed by Biosceptre International Ltd filed Critical Biosceptre International Ltd
Publication of CA2459348A1 publication Critical patent/CA2459348A1/fr
Application granted granted Critical
Publication of CA2459348C publication Critical patent/CA2459348C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

La présente invention concerne une grande variété de maladies et de conditions, y compris les cancers. L'invention propose une sonde destinée à la détection d'une telle maladie ou condition. La sonde est capable de distinguer entre des récepteurs fonctionnels de P2X¿7? et de récepteurs non fonctionnels de P2X¿7?. La sonde peut établir cette distinction de diverse manières, dont une consiste en la détection d'une modification par rapport à la liaison de l'adénosine triphosphate (ATP) aux récepteurs. L'invention propose également un procédé permettant la détection de la maladie ou condition, utilisant la sonde. L'invention concerne en outre un traitement de la maladie ou condition, au moyen d'un anticorps, ou d'un épitope capable de générer l'anticorps, pouvant établir la distinction entre les récepteurs fonctionnels et non fonctionnels de P2X¿7?. Enfin, l'invention concerne des procédés de traitement, des compositions pharmaceutiques et l'utilisation de la sonde et de l'anticorps
CA2459348A 2001-09-03 2002-09-03 Anticorps au recepteur p2x7 non fonctionnel, diagnostic et traitement de cancers et d'autres conditions Expired - Lifetime CA2459348C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
AUPR7431 2001-09-03
AUPR7430 2001-09-03
AUPR7431A AUPR743101A0 (en) 2001-09-03 2001-09-03 A cancer therapeutic
AUPR7430A AUPR743001A0 (en) 2001-09-03 2001-09-03 Diagnosis and treatment of irritable bowel syndrome
AUPCT/AU02/00061 2002-01-17
PCT/AU2002/000061 WO2002057306A1 (fr) 2001-01-17 2002-01-17 Anticorps du recepteur p2x7 non fonctionnel, diagnostic et traitement de cancers et autres etats pathologiques
PCT/AU2002/001204 WO2003020762A1 (fr) 2001-09-03 2002-09-03 Anticorps au recepteur p2x7 non fonctionnel, diagnostic et traitement de cancers et d'autres conditions

Publications (2)

Publication Number Publication Date
CA2459348A1 CA2459348A1 (fr) 2003-03-13
CA2459348C true CA2459348C (fr) 2013-06-18

Family

ID=41706691

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2459348A Expired - Lifetime CA2459348C (fr) 2001-09-03 2002-09-03 Anticorps au recepteur p2x7 non fonctionnel, diagnostic et traitement de cancers et d'autres conditions

Country Status (9)

Country Link
JP (1) JP4467973B2 (fr)
CN (2) CN100497386C (fr)
AU (1) AU2002322192B2 (fr)
CA (1) CA2459348C (fr)
MY (1) MY142283A (fr)
NZ (2) NZ549019A (fr)
TW (1) TWI329648B (fr)
WO (1) WO2003020762A1 (fr)
ZA (1) ZA200402630B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1360203E (pt) 2001-01-17 2009-04-03 Intreat Pty Ltd Anticorpos de receptor p2x7 não funcional para diagnóstico e tratamento de cancros e outros estados
AU2003298003A1 (en) * 2002-12-05 2004-06-30 Kla-Tencor Technologies Corporation Apparatus and methods for detecting overlay errors using scatterometry
WO2004090097A2 (fr) 2003-04-03 2004-10-21 Bristol-Myers Squibb Company Polynucleotide codant un nouveau variant d'epissage p2x7 humain appele hbmyp2x7v
US8124730B1 (en) 2004-04-02 2012-02-28 Bristol-Myers Squibb Company Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v
US7767789B2 (en) * 2005-06-02 2010-08-03 University Hopitals of Cleveland Truncated proteins as cancer markers
WO2008043146A1 (fr) * 2006-10-10 2008-04-17 Biosceptre International Limited Anticorps contre le récepteur p2x7 non fonctionnel
AU2007306924A1 (en) * 2006-10-10 2008-04-17 Biosceptre International Limited Hybridomas producing antibodies against non functional P2X7 receptor
CA2737126C (fr) * 2007-09-14 2018-05-01 Biosceptre International Limited Nouveaux epitopes p2x7
AU2013238152B2 (en) * 2007-09-14 2015-09-24 Biosceptre International Limited Purinergic (P2X) receptors in extra-cellular body fluid
US8293491B2 (en) 2007-09-14 2012-10-23 Biosceptre International Limited Purinergic (P2X) receptors in extra-cellular body fluid
AU2009266430B2 (en) 2008-07-04 2014-08-14 Biosceptre International Limited Anti- P2X7 peptides and epitopes
CN101469352B (zh) * 2008-08-29 2011-12-21 苏州福英基因科技有限公司 一种早期子宫癌原位杂交检测试剂盒
EP2966090B1 (fr) 2009-08-20 2018-10-10 Biosceptre (Aust) Pty Ltd Anticorps du récepteur anti p2x7 et fragments de ceux-ci
WO2011075789A1 (fr) 2009-12-24 2011-06-30 Biosceptre International Limited Anticorps dirigés contre des récepteurs p2x7 oligomères non fonctionnels
CN106310245A (zh) 2010-09-10 2017-01-11 生物权威(澳大利亚)有限责任公司 陪伴动物治疗
AU2012278921B2 (en) * 2011-07-01 2016-11-10 Biosceptre International Limited Combination therapy
EP2990800A1 (fr) * 2014-08-29 2016-03-02 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol Neprilysin comme marqueur pronostique pour l'insuffisance cardiaque
EP3347474B1 (fr) 2015-09-11 2020-11-04 Biosceptre (UK) Limited Récepteurs d'antigènes chimériques et leurs utilisations
AU2017346936B2 (en) * 2016-10-21 2022-10-06 Biosceptre (Aust) Pty Ltd Cytotoxic particles
CN110054691B (zh) * 2019-05-09 2021-09-07 潍坊医学院 一种抗人p2rx7单克隆抗体的杂交瘤细胞系

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133434A (en) * 1997-04-28 2000-10-17 Glaxo Group Limited Purinergic receptor
PT1360203E (pt) * 2001-01-17 2009-04-03 Intreat Pty Ltd Anticorpos de receptor p2x7 não funcional para diagnóstico e tratamento de cancros e outros estados

Also Published As

Publication number Publication date
WO2003020762A1 (fr) 2003-03-13
NZ549019A (en) 2008-05-30
CN100497386C (zh) 2009-06-10
CA2459348A1 (fr) 2003-03-13
NZ565994A (en) 2010-02-26
JP2005513416A (ja) 2005-05-12
CN1625565A (zh) 2005-06-08
AU2002322192B2 (en) 2008-05-01
MY142283A (en) 2010-11-15
ZA200402630B (en) 2005-06-29
JP4467973B2 (ja) 2010-05-26
CN101445555B (zh) 2013-07-03
TWI329648B (en) 2010-09-01
CN101445555A (zh) 2009-06-03

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US10450380B2 (en) Polypeptide immunogen for generating an antibody to non-functional P2X7 receptor
CA2459348C (fr) Anticorps au recepteur p2x7 non fonctionnel, diagnostic et traitement de cancers et d'autres conditions
AU2002322192A1 (en) Antibodies to non-functional P2X7receptor, diagnosis and treatment of cancers and other conditions
Barden et al. Antibodies to non-functional P2X7 receptor
Barden et al. Non-functional P2X 7 receptor

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