CA2457631C - A method of reducing space charge in a linear ion trap mass spectrometer - Google Patents

A method of reducing space charge in a linear ion trap mass spectrometer Download PDF

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Publication number
CA2457631C
CA2457631C CA2457631A CA2457631A CA2457631C CA 2457631 C CA2457631 C CA 2457631C CA 2457631 A CA2457631 A CA 2457631A CA 2457631 A CA2457631 A CA 2457631A CA 2457631 C CA2457631 C CA 2457631C
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CA
Canada
Prior art keywords
mass spectrometer
ion
ion trap
ions
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2457631A
Other languages
English (en)
French (fr)
Other versions
CA2457631A1 (en
Inventor
James W. Hager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems Canada Ltd
Nordion Inc
Original Assignee
MDS Inc
Applied Biosystems Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MDS Inc, Applied Biosystems Canada Ltd filed Critical MDS Inc
Publication of CA2457631A1 publication Critical patent/CA2457631A1/en
Application granted granted Critical
Publication of CA2457631C publication Critical patent/CA2457631C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/4265—Controlling the number of trapped ions; preventing space charge effects
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S430/00—Radiation imagery chemistry: process, composition, or product thereof
    • Y10S430/143—Electron beam

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CA2457631A 2001-08-30 2002-08-14 A method of reducing space charge in a linear ion trap mass spectrometer Expired - Fee Related CA2457631C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31571501P 2001-08-30 2001-08-30
US60/315,715 2001-08-30
PCT/CA2002/001257 WO2003019614A2 (en) 2001-08-30 2002-08-14 A method of reducing space charge in a linear ion trap mass spectrometer

Publications (2)

Publication Number Publication Date
CA2457631A1 CA2457631A1 (en) 2003-03-06
CA2457631C true CA2457631C (en) 2010-04-27

Family

ID=23225723

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2457631A Expired - Fee Related CA2457631C (en) 2001-08-30 2002-08-14 A method of reducing space charge in a linear ion trap mass spectrometer

Country Status (8)

Country Link
US (2) US20040238737A1 (enExample)
EP (1) EP1421600B1 (enExample)
JP (1) JP4303108B2 (enExample)
AT (1) ATE298463T1 (enExample)
AU (1) AU2002322895A1 (enExample)
CA (1) CA2457631C (enExample)
DE (1) DE60204785T2 (enExample)
WO (1) WO2003019614A2 (enExample)

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US6720554B2 (en) * 2000-07-21 2004-04-13 Mds Inc. Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
CA2457631C (en) * 2001-08-30 2010-04-27 Mds Inc., Doing Business As Mds Sciex A method of reducing space charge in a linear ion trap mass spectrometer
US7045797B2 (en) * 2002-08-05 2006-05-16 The University Of British Columbia Axial ejection with improved geometry for generating a two-dimensional substantially quadrupole field
US6897438B2 (en) * 2002-08-05 2005-05-24 University Of British Columbia Geometry for generating a two-dimensional substantially quadrupole field
EP1586104A2 (en) * 2003-01-24 2005-10-19 Thermo Finnigan LLC Controlling ion populations in a mass analyzer
GB0312940D0 (en) * 2003-06-05 2003-07-09 Shimadzu Res Lab Europe Ltd A method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis
JP5027507B2 (ja) * 2003-09-25 2012-09-19 エムディーエス インコーポレイテッド ドゥーイング ビジネス アズ エムディーエス サイエックス 選択された六重極成分を有する２次元の実質的四重極電場を提供するための方法及び装置
DE102004001514A1 (de) * 2004-01-09 2005-08-04 Marcus Dr.-Ing. Gohl Verfahren und Vorrichtung zur Bestimmung des Schmierölgehalts in einem Abgasgemisch
EP1889282A4 (en) * 2005-05-18 2011-01-19 Mds Inc Dba Mds Sciex METHOD AND DEVICE FOR MASS-ACTIVE AXIAL TRANSPORT USING FOUR-POINT DC-DC
GB0511083D0 (en) 2005-05-31 2005-07-06 Thermo Finnigan Llc Multiple ion injection in mass spectrometry
DE102005025498B4 (de) * 2005-06-03 2008-12-24 Bruker Daltonik Gmbh Füllstandsregelung in Ionenzyklotronresonanz- Massenspetrometern
JP4636943B2 (ja) * 2005-06-06 2011-02-23 株式会社日立ハイテクノロジーズ 質量分析装置
JP4369454B2 (ja) 2006-09-04 2009-11-18 株式会社日立ハイテクノロジーズ イオントラップ質量分析方法
US7633059B2 (en) 2006-10-13 2009-12-15 Agilent Technologies, Inc. Mass spectrometry system having ion deflector
GB0624679D0 (en) * 2006-12-11 2007-01-17 Shimadzu Corp A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
US7629575B2 (en) * 2007-12-19 2009-12-08 Varian, Inc. Charge control for ionic charge accumulation devices
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
US8822916B2 (en) 2008-06-09 2014-09-02 Dh Technologies Development Pte. Ltd. Method of operating tandem ion traps
US8766170B2 (en) * 2008-06-09 2014-07-01 Dh Technologies Development Pte. Ltd. Method of operating tandem ion traps
CA2720249C (en) * 2008-06-09 2015-12-08 Dh Technologies Development Pte. Ltd. A multipole ion guide for providing an axial electric field whose strength increases with radial position, and a method of operating a multipole ion guide having such an axial electric field
GB0810599D0 (en) 2008-06-10 2008-07-16 Micromass Ltd Mass spectrometer
US20100096544A1 (en) * 2008-10-16 2010-04-22 Battelle Memorial Institute Surface Sampling Probe for Field Portable Surface Sampling Mass Spectrometer
GB0900917D0 (en) 2009-01-20 2009-03-04 Micromass Ltd Mass spectrometer
US20100237236A1 (en) * 2009-03-20 2010-09-23 Applera Corporation Method Of Processing Multiple Precursor Ions In A Tandem Mass Spectrometer
CN102422129B (zh) * 2009-05-11 2015-03-25 萨莫芬尼根有限责任公司 在具有质量选择性传送光学器件的质谱仪中的离子布居控制
GB2511582B (en) * 2011-05-20 2016-02-10 Thermo Fisher Scient Bremen Method and apparatus for mass analysis
US9318310B2 (en) * 2011-07-11 2016-04-19 Dh Technologies Development Pte. Ltd. Method to control space charge in a mass spectrometer
EP2786399B1 (en) * 2011-11-29 2019-10-09 Thermo Finnigan LLC Method for automated checking and adjustment of mass spectrometer calibration
EP2795665A4 (en) 2011-12-23 2015-08-12 Dh Technologies Dev Pte Ltd METHOD AND SYSTEM FOR QUANTITATIVE AND QUALITATIVE ANALYSIS USING MASS SPECTROMETRY
US8759752B2 (en) 2012-03-12 2014-06-24 Thermo Finnigan Llc Corrected mass analyte values in a mass spectrum
WO2014140622A1 (en) 2013-03-14 2014-09-18 Micromass Uk Limited Improved method of data dependent control
US8969794B2 (en) * 2013-03-15 2015-03-03 1St Detect Corporation Mass dependent automatic gain control for mass spectrometer
GB201307404D0 (en) * 2013-04-24 2013-06-05 Micromass Ltd Improved ion mobility spectrometer
US10088451B2 (en) 2013-04-24 2018-10-02 Micromass Uk Limited Ion mobility spectrometer
GB201316164D0 (en) 2013-09-11 2013-10-23 Thermo Fisher Scient Bremen Targeted mass analysis
EP3321953B1 (en) 2016-11-10 2019-06-26 Thermo Finnigan LLC Systems and methods for scaling injection waveform amplitude during ion isolation
US10128099B1 (en) * 2017-07-20 2018-11-13 Thermo Finnigan Llc Systems and methods for regulating the ion population in an ion trap for MSn scans
EP3918629A1 (en) * 2019-02-01 2021-12-08 DH Technologies Development Pte. Ltd. Auto gain control for optimum ion trap filling
GB201906546D0 (en) 2019-05-09 2019-06-26 Thermo Fisher Scient Bremen Gmbh Charge detection for ion current control

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IT528250A (enExample) * 1953-12-24
US5107109A (en) * 1986-03-07 1992-04-21 Finnigan Corporation Method of increasing the dynamic range and sensitivity of a quadrupole ion trap mass spectrometer
US4755670A (en) * 1986-10-01 1988-07-05 Finnigan Corporation Fourtier transform quadrupole mass spectrometer and method
US5179278A (en) * 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
DE4326549C1 (de) * 1993-08-07 1994-08-25 Bruker Franzen Analytik Gmbh Verfahren für eine Regelung der Raumladung in Ionenfallen
US6011259A (en) * 1995-08-10 2000-01-04 Analytica Of Branford, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSN analysis
US5420425A (en) * 1994-05-27 1995-05-30 Finnigan Corporation Ion trap mass spectrometer system and method
US5572022A (en) * 1995-03-03 1996-11-05 Finnigan Corporation Method and apparatus of increasing dynamic range and sensitivity of a mass spectrometer
US6177668B1 (en) * 1996-06-06 2001-01-23 Mds Inc. Axial ejection in a multipole mass spectrometer
CA2457631C (en) * 2001-08-30 2010-04-27 Mds Inc., Doing Business As Mds Sciex A method of reducing space charge in a linear ion trap mass spectrometer

Also Published As

Publication number Publication date
AU2002322895A1 (en) 2003-03-10
EP1421600A2 (en) 2004-05-26
WO2003019614A3 (en) 2003-06-19
JP4303108B2 (ja) 2009-07-29
US6627876B2 (en) 2003-09-30
ATE298463T1 (de) 2005-07-15
DE60204785T2 (de) 2006-05-04
US20030042415A1 (en) 2003-03-06
US20040238737A1 (en) 2004-12-02
WO2003019614A2 (en) 2003-03-06
DE60204785D1 (de) 2005-07-28
CA2457631A1 (en) 2003-03-06
JP2005500662A (ja) 2005-01-06
EP1421600B1 (en) 2005-06-22

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Effective date: 20200831