CA2455951A1 - Bi-directional synthesis of oligoguanidine transport agents - Google Patents

Bi-directional synthesis of oligoguanidine transport agents Download PDF

Info

Publication number
CA2455951A1
CA2455951A1 CA002455951A CA2455951A CA2455951A1 CA 2455951 A1 CA2455951 A1 CA 2455951A1 CA 002455951 A CA002455951 A CA 002455951A CA 2455951 A CA2455951 A CA 2455951A CA 2455951 A1 CA2455951 A1 CA 2455951A1
Authority
CA
Canada
Prior art keywords
compound
arginine
oligoguanidine
group
ornithine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002455951A
Other languages
English (en)
French (fr)
Inventor
Paul A. Wender
Christopher L. Vandeusen
Kanaka Pattabiraman
Erin T. Pelkey
Theodore C. Jessop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2455951A1 publication Critical patent/CA2455951A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA002455951A 2001-08-03 2002-08-02 Bi-directional synthesis of oligoguanidine transport agents Abandoned CA2455951A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31030501P 2001-08-03 2001-08-03
US60/310,305 2001-08-03
PCT/US2002/024645 WO2003014076A2 (en) 2001-08-03 2002-08-02 Bi-directional synthesis of oligoguanidine transport agents

Publications (1)

Publication Number Publication Date
CA2455951A1 true CA2455951A1 (en) 2003-02-20

Family

ID=23201904

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002455951A Abandoned CA2455951A1 (en) 2001-08-03 2002-08-02 Bi-directional synthesis of oligoguanidine transport agents

Country Status (6)

Country Link
US (1) US7067698B2 (cg-RX-API-DMAC10.html)
EP (1) EP1419172A4 (cg-RX-API-DMAC10.html)
JP (1) JP2004537596A (cg-RX-API-DMAC10.html)
CA (1) CA2455951A1 (cg-RX-API-DMAC10.html)
MX (1) MXPA04001142A (cg-RX-API-DMAC10.html)
WO (1) WO2003014076A2 (cg-RX-API-DMAC10.html)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10456443B2 (en) 2014-08-27 2019-10-29 Ohio State Innovation Foundation Peptidyl calcineurin inhibitors
US10626147B2 (en) 2014-05-21 2020-04-21 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US11168310B2 (en) 2018-02-22 2021-11-09 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
US11576946B2 (en) 2018-01-29 2023-02-14 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction
US11987647B2 (en) 2018-05-09 2024-05-21 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with one or more hydrophobic residues
US12281181B2 (en) 2017-10-04 2025-04-22 Ohio State Innovation Foundation Bicyclic peptidyl inhibitors
US12496350B2 (en) 2018-01-29 2025-12-16 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of CAL-PDZ binding domain

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007038169A2 (en) * 2005-09-23 2007-04-05 Nitto Denko Corporation Multi-valent guanidinium compounds for molecular translocation across cellular membranes and epithelial tissues
WO2007038172A2 (en) * 2005-09-23 2007-04-05 Nitto Denko Corporation Guanidinium carriers
US7700565B2 (en) * 2005-09-23 2010-04-20 Nitto Denko Corporation Peptide nucleic acid based guanidinium compounds
US20100062465A1 (en) * 2006-04-21 2010-03-11 Ronen Sabrina M Detection of Histone Deacetylase Inhibition
US8624006B2 (en) 2007-04-09 2014-01-07 The Regents Of The University Of California One-pot synthesis of alpha/beta-O-glycolipids
AU2021386370A1 (en) 2020-11-24 2023-06-22 Lyell Immunopharma, Inc. Methods for making, compositions comprising, and methods of using rejuvenated t cells

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694086A (en) * 1983-10-05 1987-09-15 Toray Industries, Inc. Guanidine derivatives
EP0684958B1 (en) * 1993-02-17 1998-06-10 Btg International Limited Polymers containing guanidino groups for use in therapy
US5627194A (en) * 1993-11-17 1997-05-06 Allelix Biopharmaceuticals Inc. Anti-viral guanidino-substituted compounds
US5925552A (en) * 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
EP0941122B1 (en) * 1996-08-13 2003-10-29 Chiron Corporation Compositions for polynucleotide delivery
TW499412B (en) * 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
WO1998036743A1 (en) * 1997-02-21 1998-08-27 Cypros Pharmaceutical Corporation Neuroprotective poly-guanidino compounds which block presynaptic n and p/q calcium channels
ES2210761T3 (es) * 1997-05-21 2004-07-01 The Board Of Trustees Of The Leland Stanford Junior University Composicion y procedimiento para mejorar el transporte a traves de las membranas biologicas.
US6072075A (en) * 1997-05-22 2000-06-06 The Regents Of The University Of California Guanidinylation reagents
US6623576B2 (en) * 1998-10-28 2003-09-23 Basf Aktiengesellschaft Continuous manufacture of superabsorbent/ion exchange sheet material
US6222091B1 (en) * 1997-11-19 2001-04-24 Basf Aktiengesellschaft Multicomponent superabsorbent gel particles
US6767904B2 (en) * 1998-03-06 2004-07-27 Bringham Young University Steroid derived antibiotics
US6350738B1 (en) * 1998-03-06 2002-02-26 Brigham Young University Steroid derived antibiotics
US6605115B1 (en) 1999-06-05 2003-08-12 Board Of Trustees Of The Leland Stanford Junior University Method and composition for inhibiting cardiovascular cell proliferation
WO2001013957A2 (en) 1999-08-24 2001-03-01 Cellgate, Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10626147B2 (en) 2014-05-21 2020-04-21 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US11225506B2 (en) 2014-05-21 2022-01-18 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10456443B2 (en) 2014-08-27 2019-10-29 Ohio State Innovation Foundation Peptidyl calcineurin inhibitors
US12281181B2 (en) 2017-10-04 2025-04-22 Ohio State Innovation Foundation Bicyclic peptidyl inhibitors
US11576946B2 (en) 2018-01-29 2023-02-14 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction
US12329799B2 (en) 2018-01-29 2025-06-17 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction
US12496350B2 (en) 2018-01-29 2025-12-16 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of CAL-PDZ binding domain
US11168310B2 (en) 2018-02-22 2021-11-09 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
US11987821B2 (en) 2018-02-22 2024-05-21 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
US12698482B2 (en) 2018-02-22 2026-08-04 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
US11987647B2 (en) 2018-05-09 2024-05-21 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with one or more hydrophobic residues

Also Published As

Publication number Publication date
WO2003014076A2 (en) 2003-02-20
EP1419172A4 (en) 2007-10-03
EP1419172A2 (en) 2004-05-19
JP2004537596A (ja) 2004-12-16
WO2003014076A3 (en) 2003-10-09
US7067698B2 (en) 2006-06-27
US20030073807A1 (en) 2003-04-17
MXPA04001142A (es) 2004-09-13

Similar Documents

Publication Publication Date Title
US10407468B2 (en) Methods for synthesizing α4β7 peptide antagonists
JP6334399B2 (ja) 自己組織化ペプチド誘導体の製造方法
US7067698B2 (en) Bi-directional synthesis of oligoguanidine transport agents
JP6011528B2 (ja) ペプチドの製造方法
JP6703669B2 (ja) リュープロレリンの製造方法
JP5171613B2 (ja) ペプチドの製造方法
US20220220151A1 (en) Method for preparing peptides
CA2761469A1 (en) Lysine compounds and their use in site- and chemoselective modification of peptides and proteins
JPH0354957B2 (cg-RX-API-DMAC10.html)
JP2003073396A (ja) ペプチドの製造方法
US20100222548A1 (en) Method for producing condensation products from n-substituted glycine derivatives(peptoids) by sequential ugi-multicomponent reactions
WO2010009196A1 (en) Synthesis of bis-peptides oligomers comprising at least one n-substituted diketopiperazine as structural moiety
WO2021177336A1 (ja) ペプチド及び細胞膜透過剤
US20060264608A1 (en) Bi-directional synthesis of oligoguanidine transport agents
AU2002321897A1 (en) Bi-directional synthesis of oligoguanidine transport agents
JP7688397B2 (ja) ペプチドの製造方法
EP2607373A1 (en) Liquid phase synthesis of self-assembling peptides to be linked to polymers or to other bioactive and/or self-assembling peptides
Demin et al. Synthesis of glutaryl-containing derivatives of GRGD and KRGD peptides
WO2000005243A2 (en) Resin derivatization method and uses thereof
Fajar et al. The c (RGDfK) synthesis on a solid‐phase utilizing a removable methyl ester group by lithium hydroxide
US5942601A (en) Peptide synthesis with sulfonyl protecting groups
Ang et al. Solid-phase synthesis of a library of C-terminal agmatine dipeptides using a backbone amide linker (BAL) strategy
RU2777327C1 (ru) Способ синтеза пептидов
US20060154325A1 (en) Synthesis of epoxide based inhibitors of cysteine proteases
Li et al. A facile synthesis of amides from 9-fluorenylmethyl carbamates and acid derivatives

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued