CA2451454A1 - Therapeutic polypeptides, nucleic acids encoding same, and methods of use - Google Patents

Therapeutic polypeptides, nucleic acids encoding same, and methods of use Download PDF

Info

Publication number
CA2451454A1
CA2451454A1 CA002451454A CA2451454A CA2451454A1 CA 2451454 A1 CA2451454 A1 CA 2451454A1 CA 002451454 A CA002451454 A CA 002451454A CA 2451454 A CA2451454 A CA 2451454A CA 2451454 A1 CA2451454 A1 CA 2451454A1
Authority
CA
Canada
Prior art keywords
novx
polypeptide
protein
nucleic acid
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002451454A
Other languages
English (en)
French (fr)
Inventor
Mei Zhong
Li Li
Linda Gorman
Kimberly A. Spytek
Ramesh Kekuda
Raymond J. Taupier, Jr.
David W. Anderson
Corine A. M. Vernet
Elina Catterton
Charles E. Miller
Suresh G. Shenoy
Meera Patturajan
Carol E. A. Pena
Velizar T. Tchernev
Muralidhara Padigaru
Vladimir Y. Gusev
Uriel M. Malyankar
Catherine E. Burgess
Valerie L. Gerlach
Stacie J. Casman
Daniel K. Rieger
William M. Grosse
Glennda Smithson
John A. Peyman
Gary Starling
Mark E. Rothenberg
William J. Larochelle
Richard A. Shimkets
Julie Crabtree
Luca Rastelli
Edward Z. Voss
Ferenc L. Boldog
Shlomit R. Edinger
Isabelle Millet
John R. Macdougall
Karen Ellerman
Andrei Chapoval
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
CuraGen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CuraGen Corp filed Critical CuraGen Corp
Publication of CA2451454A1 publication Critical patent/CA2451454A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
CA002451454A 2001-09-07 2002-09-09 Therapeutic polypeptides, nucleic acids encoding same, and methods of use Abandoned CA2451454A1 (en)

Applications Claiming Priority (51)

Application Number Priority Date Filing Date Title
US31813001P 2001-09-07 2001-09-07
US31821901P 2001-09-07 2001-09-07
US31812001P 2001-09-07 2001-09-07
US60/318,130 2001-09-07
US60/318,219 2001-09-07
US60/318,120 2001-09-07
US31843001P 2001-09-10 2001-09-10
US60/318,430 2001-09-10
US31876501P 2001-09-12 2001-09-12
US60/318,765 2001-09-12
US32281601P 2001-09-17 2001-09-17
US32278101P 2001-09-17 2001-09-17
US60/322,816 2001-09-17
US60/322,781 2001-09-17
US32351901P 2001-09-19 2001-09-19
US60/323,519 2001-09-19
US32363101P 2001-09-20 2001-09-20
US32363601P 2001-09-20 2001-09-20
US60/323,631 2001-09-20
US60/323,636 2001-09-20
US32496901P 2001-09-25 2001-09-25
US32509101P 2001-09-25 2001-09-25
US60/325,091 2001-09-25
US60/324,969 2001-09-25
US32499001P 2001-09-26 2001-09-26
US60/324,990 2001-09-26
US35730302P 2002-02-15 2002-02-15
US60/357,303 2002-02-15
US36097302P 2002-02-28 2002-02-28
US60/360,973 2002-02-28
US36613102P 2002-03-20 2002-03-20
US60/366,131 2002-03-20
US36775302P 2002-03-25 2002-03-25
US60/367,753 2002-03-25
US36947902P 2002-04-02 2002-04-02
US60/369,479 2002-04-02
US37953202P 2002-05-10 2002-05-10
US60/379,532 2002-05-10
US38167202P 2002-05-17 2002-05-17
US38166402P 2002-05-17 2002-05-17
US60/381,672 2002-05-17
US60/381,664 2002-05-17
US38365102P 2002-05-28 2002-05-28
US60/383,651 2002-05-28
US38401202P 2002-05-29 2002-05-29
US60/384,012 2002-05-29
US39015502P 2002-06-19 2002-06-19
US60/390,155 2002-06-19
US10/236,392 US20040067490A1 (en) 2001-09-07 2002-09-06 Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US10/236,392 2002-09-06
PCT/US2002/028596 WO2003023008A2 (en) 2001-09-07 2002-09-09 Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publications (1)

Publication Number Publication Date
CA2451454A1 true CA2451454A1 (en) 2003-03-20

Family

ID=32046248

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002451454A Abandoned CA2451454A1 (en) 2001-09-07 2002-09-09 Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Country Status (5)

Country Link
US (1) US20040067490A1 (ja)
EP (1) EP1576086A2 (ja)
JP (1) JP2005512515A (ja)
CA (1) CA2451454A1 (ja)
WO (1) WO2003023008A2 (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1218406A1 (en) * 1999-08-11 2002-07-03 Curagen Corporation Nucleic acids and secreted polypeptides encoded thereby
US20020159961A1 (en) 2001-02-13 2002-10-31 Ajinomoto Co. Inc. Gelling agent for oil
US20030077775A1 (en) * 2001-10-17 2003-04-24 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
JP3955885B2 (ja) * 2002-12-29 2007-08-08 日産化学工業株式会社 アディポネクチン受容体及びそれをコードする遺伝子
PL1606409T3 (pl) 2003-03-19 2011-02-28 Biogen Ma Inc Białko wiążące receptor Nogo
WO2004094608A2 (en) * 2003-04-18 2004-11-04 Curagen Corporation Human procolipase like nucleic acids and polypeptides and their methods of use threof
ES2347562T3 (es) 2003-09-27 2010-11-02 Siemens Healthcare Diagnostics Inc. Disagnosticos y terapias para enfermedades asociados con receptor emparejado de proteina g adipor1 (adipor1).
JP4960865B2 (ja) * 2004-06-24 2012-06-27 バイオジェン・アイデック・エムエイ・インコーポレイテッド 脱髄に関連する状態の処置
SI1904104T1 (sl) 2005-07-08 2013-12-31 Biogen Idec Ma Inc. Protitelesa SP35 in njihova uporaba
US8093017B2 (en) 2005-12-07 2012-01-10 Siemens Heathcare Diagnostics Inc. Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics
US8128926B2 (en) 2007-01-09 2012-03-06 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
US20080233117A1 (en) * 2007-01-22 2008-09-25 Mayo Foundation For Medical Education And Research Reducing tumor growth
EP2205071B1 (en) * 2007-10-11 2015-07-22 Biogen MA Inc. Lingo-1 antagonists and trkb agonists for use in the treatment of glaucoma
CN101918540B (zh) * 2007-11-08 2016-05-11 比奥根Ma公司 Lingo-4拮抗剂在治疗涉及脱髓鞘的疾患中的应用
CN101932728B (zh) 2007-11-30 2013-06-19 西门子医疗保健诊断公司 脂连蛋白受体片段和使用方法
KR101766627B1 (ko) 2008-03-19 2017-08-08 차이나 신테틱 러버 코포레이션 간세포 암종의 진단 및 치료를 위한 방법 및 제제
WO2010123720A1 (en) 2009-04-23 2010-10-28 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
CA2729961C (en) * 2008-07-09 2018-05-01 Biogen Idec Ma Inc. Li113, li62 variant co2, anti-lingo antibodies
DK2346904T3 (en) 2008-10-29 2017-06-12 China Synthetic Rubber Corp METHODS AND METHODS OF DIAGNOSIS AND TREATMENT OF HEPATOCELLULAR CARCINOM
PE20150091A1 (es) 2012-02-24 2015-02-16 Stem Centrx Inc Anticuerpos anti-sez6 y metodos de empleo
MX2014013950A (es) 2012-05-14 2015-02-17 Biogen Idec Inc Antagonistas de proteina que interactua con el receptor nogo 2 que contiene repeticion rica en leucina y dominio de inmunoglobulina (lingo-2) para el tratamiento de afecciones que involucran neuronas motoras.
EP3892294A1 (en) * 2013-08-28 2021-10-13 AbbVie Stemcentrx LLC Site-specific antibody conjugation methods and compositions
JP2016538318A (ja) 2013-08-28 2016-12-08 ステムセントリックス， インコーポレイテッド 新規ｓｅｚ６モジュレーターおよび使用方法
US9493552B2 (en) 2013-11-15 2016-11-15 China Synthetic Rubber Corporation Therapeutic biologic for treatment of hepatocellular carcinoma
US10308721B2 (en) 2014-02-21 2019-06-04 Abbvie Stemcentrx Llc Anti-DLL3 antibodies and drug conjugates for use in melanoma
CA2973266A1 (en) 2015-01-08 2016-07-14 Biogen Ma Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders
CA3108731A1 (en) * 2018-08-03 2020-02-06 Scripps Health Detection and isolation of myeloid-derived suppressor cell subpopulations
CN110208276B (zh) * 2019-07-02 2023-03-31 广州越监工程质量安全检测中心有限公司 一种结构砼表观缺陷测定仪及其检测设备

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4870009A (en) * 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) * 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5080891A (en) * 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5639660A (en) * 1988-02-24 1997-06-17 Hoffmann-La Roche Inc. Polypeptide and DNA sequence corresponding to the human receptor with high affinity for IgE
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5272057A (en) * 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5459039A (en) * 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5622930A (en) * 1989-10-27 1997-04-22 Clb C1 inhibitor muteins and uses thereof
JP3068180B2 (ja) * 1990-01-12 2000-07-24 アブジェニックス インコーポレイテッド 異種抗体の生成
US5661016A (en) * 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) * 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) * 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ATE158021T1 (de) * 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5633425A (en) * 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5527679A (en) * 1991-05-01 1996-06-18 Dana Farber Cancer Institute β5 protein and DNA encoding the same
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5233409A (en) * 1992-02-25 1993-08-03 Schwab Karl W Color analysis of organic constituents in sedimentary rocks for thermal maturity
AU5294993A (en) * 1992-10-01 1994-04-26 Board Of Regents, The University Of Texas System Epidermal surface antigen and uses thereof
EP0657811B1 (en) * 1993-12-09 1998-09-02 STMicroelectronics S.r.l. Integrated circuitry for checking the utilization rate of redundancy memory elements in a semiconductor memory device
US5635360A (en) * 1995-03-15 1997-06-03 Becton, Dickinson And Company Immunoassay for human restrictin
US5736866A (en) * 1995-11-13 1998-04-07 Kabushiki Kaisha Toshiba Active pull-down circuit for ECL using a capacitive coupled circuit
US6083693A (en) * 1996-06-14 2000-07-04 Curagen Corporation Identification and comparison of protein-protein interactions that occur in populations
US5916771A (en) * 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
US6326472B1 (en) * 1997-10-15 2001-12-04 Schering Corporation Human receptor proteins; related reagents and methods
EP1218406A1 (en) * 1999-08-11 2002-07-03 Curagen Corporation Nucleic acids and secreted polypeptides encoded thereby
US20030211991A1 (en) * 2001-04-17 2003-11-13 Su Eric Wen Human sez6 nucleic acids and polypeptides

Also Published As

Publication number Publication date
EP1576086A2 (en) 2005-09-21
WO2003023008A8 (en) 2005-10-27
WO2003023008A2 (en) 2003-03-20
US20040067490A1 (en) 2004-04-08
JP2005512515A (ja) 2005-05-12

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