CA2451201A1 - Microfabricated two-pin liquid sample dispensing system - Google Patents

Microfabricated two-pin liquid sample dispensing system Download PDF

Info

Publication number
CA2451201A1
CA2451201A1 CA002451201A CA2451201A CA2451201A1 CA 2451201 A1 CA2451201 A1 CA 2451201A1 CA 002451201 A CA002451201 A CA 002451201A CA 2451201 A CA2451201 A CA 2451201A CA 2451201 A1 CA2451201 A1 CA 2451201A1
Authority
CA
Canada
Prior art keywords
liquid sample
pin
tip
dispensing system
sample dispensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002451201A
Other languages
English (en)
French (fr)
Inventor
John Gilbert
John Harley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytonome Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/027,922 external-priority patent/US20030077570A1/en
Priority claimed from US10/027,171 external-priority patent/US7041257B2/en
Priority claimed from US10/027,484 external-priority patent/US20030015425A1/en
Priority claimed from US10/028,852 external-priority patent/US7179423B2/en
Priority claimed from US10/029,108 external-priority patent/US6808683B2/en
Priority claimed from US10/027,516 external-priority patent/US20020197733A1/en
Application filed by Individual filed Critical Individual
Publication of CA2451201A1 publication Critical patent/CA2451201A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B01L3/0248—Prongs, quill pen type dispenser
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
CA002451201A 2001-06-20 2002-06-20 Microfabricated two-pin liquid sample dispensing system Abandoned CA2451201A1 (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US29951501P 2001-06-20 2001-06-20
US60/299,515 2001-06-20
US32500101P 2001-09-25 2001-09-25
US60/325,001 2001-09-25
US10/028,852 2001-12-21
US10/029,108 2001-12-21
US10/027,516 2001-12-21
US10/027,171 2001-12-21
US10/027,922 US20030077570A1 (en) 2001-09-20 2001-12-21 Small molecule substrate based enzyme activity assays
US10/027,171 US7041257B2 (en) 2001-09-25 2001-12-21 Microfabricated two-pin liquid sample dispensing system
US10/027,484 US20030015425A1 (en) 2001-06-20 2001-12-21 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US10/027,922 2001-12-21
US10/028,852 US7179423B2 (en) 2001-06-20 2001-12-21 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US10/027,484 2001-12-21
US10/029,108 US6808683B2 (en) 2001-09-25 2001-12-21 Droplet dispensing system
US10/027,516 US20020197733A1 (en) 2001-06-20 2001-12-21 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
PCT/US2002/019924 WO2003000422A1 (en) 2001-06-20 2002-06-20 Microfabricated two-pin liquid sample dispensing system

Publications (1)

Publication Number Publication Date
CA2451201A1 true CA2451201A1 (en) 2003-01-03

Family

ID=27574128

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002451201A Abandoned CA2451201A1 (en) 2001-06-20 2002-06-20 Microfabricated two-pin liquid sample dispensing system

Country Status (4)

Country Link
EP (1) EP1412087A4 (ja)
JP (1) JP2005502448A (ja)
CA (1) CA2451201A1 (ja)
WO (1) WO2003000422A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153699B2 (en) * 2001-12-21 2006-12-26 Cytonome, Inc. Microfabricated two-pin system for biomolecule crystallization
US7258839B2 (en) * 2001-12-21 2007-08-21 Cytonome, Inc. Temperature controlled microfabricated two-pin liquid sample dispensing system
JP4624133B2 (ja) * 2004-03-29 2011-02-02 京セラ株式会社 液体印刷ピン
WO2013138724A2 (en) * 2012-03-16 2013-09-19 Life Technologies Corporation Systems and methods for loading liquid samples
EP3502650B1 (en) * 2017-12-22 2023-07-19 Universiteit Maastricht Method of and apparatus for applying liquid to a substrate
JP7475953B2 (ja) 2020-05-01 2024-04-30 キヤノンメディカルシステムズ株式会社 自動分析装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2193480A5 (ja) * 1972-07-19 1974-02-15 Nickel Le
US4116069A (en) * 1976-07-16 1978-09-26 Georgy Mikhailovich Lezgintsev Device for taking bottom soil samples from deep water basins
US4659677A (en) * 1983-05-26 1987-04-21 Eastman Kodak Company Method providing liquid mixing outside containers
RU2041263C1 (ru) * 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
US5356052A (en) * 1993-10-13 1994-10-18 Healthstar Inc. BFS metered drop bottle
US6024925A (en) * 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5882930A (en) * 1997-11-10 1999-03-16 Hyseq, Inc. Reagent transfer device
US5957167A (en) * 1997-12-18 1999-09-28 Pharmacopeia, Inc. Article for dispensing small volumes of liquid
US6309891B1 (en) * 1998-09-09 2001-10-30 Incyte Genomics, Inc. Capillary printing systems
US6387330B1 (en) * 2000-04-12 2002-05-14 George Steven Bova Method and apparatus for storing and dispensing reagents
US6610253B2 (en) * 2000-05-31 2003-08-26 Autosplice, Inc. Liquid pin transfer assembly with common pin bias
JP2002001092A (ja) * 2000-06-22 2002-01-08 Shimadzu Corp 排液装置

Also Published As

Publication number Publication date
WO2003000422A1 (en) 2003-01-03
EP1412087A4 (en) 2005-03-09
EP1412087A1 (en) 2004-04-28
JP2005502448A (ja) 2005-01-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued