CA2435287A1 - Nucleic acid delivery formulations - Google Patents

Nucleic acid delivery formulations Download PDF

Info

Publication number
CA2435287A1
CA2435287A1 CA002435287A CA2435287A CA2435287A1 CA 2435287 A1 CA2435287 A1 CA 2435287A1 CA 002435287 A CA002435287 A CA 002435287A CA 2435287 A CA2435287 A CA 2435287A CA 2435287 A1 CA2435287 A1 CA 2435287A1
Authority
CA
Canada
Prior art keywords
formulation
nucleic acid
components
reactive
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002435287A
Other languages
English (en)
French (fr)
Inventor
Shikha P. Barman
Krishnendu Roy
Mary Lynne Hedley
Daqing Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2435287A1 publication Critical patent/CA2435287A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA002435287A 2001-01-17 2002-01-17 Nucleic acid delivery formulations Abandoned CA2435287A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US26221901P 2001-01-17 2001-01-17
US60/262,219 2001-01-17
US27025601P 2001-02-20 2001-02-20
US60/270,256 2001-02-20
US30048401P 2001-06-22 2001-06-22
US60/300,484 2001-06-22
PCT/US2002/001379 WO2002057424A2 (en) 2001-01-17 2002-01-17 Nucleic acid delivery formulations

Publications (1)

Publication Number Publication Date
CA2435287A1 true CA2435287A1 (en) 2002-07-25

Family

ID=27401491

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002435287A Abandoned CA2435287A1 (en) 2001-01-17 2002-01-17 Nucleic acid delivery formulations

Country Status (4)

Country Link
EP (1) EP1352072A4 (ja)
JP (1) JP2004521109A (ja)
CA (1) CA2435287A1 (ja)
WO (1) WO2002057424A2 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7375096B1 (en) 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
WO2003070905A2 (en) * 2002-02-15 2003-08-28 Zycos, Inc. Electroporation methods for introducing bioactive agents into cells
EP1534340B1 (en) 2002-09-06 2011-11-16 Cerulean Pharma Inc. Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
CN101415443A (zh) * 2003-10-23 2009-04-22 阿尔扎公司 涂覆微喷射体的稳定dna组合物
WO2006053836A1 (en) * 2004-11-16 2006-05-26 Universite De Liege Active substance delivery system comprising a hydrogel atrix and microcarriers
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
US9393309B2 (en) * 2011-04-19 2016-07-19 Kyoto University Self-gelatinizable nucleic acid
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US11452759B2 (en) * 2015-01-19 2022-09-27 Technion Research & Development Foundation Limited Ubiquitin ligase KPC1 promotes processing of P105 NF-κB1 to p50, eliciting strong tumor suppression
KR101637883B1 (ko) * 2015-09-30 2016-07-21 선바이오(주) 폴리에틸렌글리콜 수화젤 주사제
KR101666792B1 (ko) * 2016-02-05 2016-10-17 주식회사 파마리서치프로덕트 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물
CN111333878B (zh) * 2019-05-23 2020-11-10 吾奇生物医疗科技(镇江)有限公司 一种双交联壳聚糖水凝胶及其制备方法和应用
CN109134855B (zh) * 2018-07-23 2021-03-23 安徽大学 一种酸敏感的聚酰胺胺的阳离子聚合物poeamam及其制备方法和应用
CN113683780B (zh) * 2021-09-15 2022-07-05 广州医科大学 具有穿膜活性和细胞核定位功能的抗血清、低细胞毒性的聚氨基酸类基因递送载体材料

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3940316A1 (de) * 1989-12-06 1991-06-13 Bollig & Kemper Waessrige dispersionen von vernetzten polymermikroteilchen
US5534259A (en) * 1993-07-08 1996-07-09 Liposome Technology, Inc. Polymer compound and coated particle composition
US6132765A (en) * 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
EP0920339A2 (en) * 1996-07-09 1999-06-09 The Johns Hopkins University Gene delivery system
WO1998016201A1 (en) * 1996-10-11 1998-04-23 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method
ATE240386T1 (de) * 1997-06-30 2003-05-15 Ciba Spec Chem Water Treat Ltd Polymere materialien und ihre verwendung
DE69810925T2 (de) * 1998-08-28 2004-01-08 Transgene S.A. Verwendung eines kationischen Polymer zur Herstellung von Nukleinsäure-Komplexe und verwandte Zusammensetzungen

Also Published As

Publication number Publication date
EP1352072A4 (en) 2004-09-01
WO2002057424A3 (en) 2002-10-03
WO2002057424A2 (en) 2002-07-25
JP2004521109A (ja) 2004-07-15
EP1352072A2 (en) 2003-10-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued